Whiteoak, Christopher - Sheffield Hallam University - Department of Biosciences and Chemistry

个人简介

Christopher was appointed as a lecturer in Inorganic Chemistry in 2016 having completed his MChem (University of York, 2004), PhD (Imperial College London, 2010) and post-doctoral research positions in France and Spain in the field of catalysis. He teaches Inorganic Chemistry and has an active research programme focusing on the development of new transition metal-catalysed C-H functionalisation protocols and the use of carbon dioxide as a renewable chemical feedstock.

研究领域

Development of novel C-H functionisation protocols To date, significant progress has been made towards the development of the new C-C and C-X bond forming protocols, with transition metal catalysis leading the field. These advances have offered new routes for significantly shortening and improving the selectivity/reducing waste in multi-step syntheses for the preparation of important pharmaceuticals, natural products and agrochemicals. Historically most success has been achieved with expensive second and third row transition metals, in particular Pd, for which Heck, Negishi and Suzuki were awarded the Nobel Prize for their key contributions in 2010. These Pd protocols require substrates containing halides resulting in significant waste issues in the chemical industry, whereas direct functionalisation of C-H bonds would provide a more atom economic solution and hence greener process. As a result, focus has now shifted towards this more challenging, selective direct functionalisation of ubiquitous C-H bonds. Meanwhile, attention is also turning towards the use of cheaper, more abundant first row transition metals. In this context, Christopher's research seeks to exploit the potential of Co as the basis for novel catalytic and systems for the development of sustainable C-H functionalisation protocols. Carbon dioxide: a renewable chemical feedstock Carbon dioxide is an interesting carbon feedstock for organic synthesis offering a number of attractive features such as being a renewable, inexpensive and readily available resource. Unfortunately, it is a relatively inert reagent and therefore requires harsh reaction conditions for its activation. In Christopher's research, he focuses on the use of transition metal and organo-catalysis as a way of lowering the high energy barriers in order to provide highly active catalyst systems for the production of value-added products

近期论文

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PLANAS, Oriol, WHITEOAK, Christopher, MARTIN-DIACONESCU, Vlad, GAMBA, Ilaria, LUIS, Josep M., PARELLA, Teodor, COMPANY, Anna and RIBAS, Xavi (2016). Isolation of Key Organometallic Aryl-Co(III) Intermediates in Cobalt-Catalyzed C(sp2)–H Functionalizations and New Insights into Alkyne Annulation Reaction Mechanisms. Journal of the American Chemical Society, 138 (43), 14388-14397. WHITEOAK, Christopher J., PLANAS, Oriol, COMPANY, Anna and RIBAS, Xavi (2016). A first example of cobalt-catalyzed remote C-H functionalization of 8-aminoquinolines operating through a single electron transfer mechanism. Advanced Synthesis & Catalysis. PLANAS, Oriol, WHITEOAK, Christopher, COMPANY, Anna and RIBAS, Xavi (2015). Regioselective Access to Sultam Motifs through Cobalt-Catalyzed Annulation of Aryl Sulfonamides and Alkynes using an 8-Aminoquinoline Directing Group. Advanced Synthesis & Catalysis, 357 (18), 4003-4012. SERRA, Jordi, WHITEOAK, Christopher, ACUÑA-PARÉS, Ferran, FONT, Marc, LUIS, Josep M., LLORET-FILLOL, Julio and RIBAS, Xavi (2015). Oxidant-Free Au(I)-Catalyzed Halide Exchange and Csp2–O Bond Forming Reactions. Journal of the American Chemical Society, 137 (41), 13389-13397. CORONA, Teresa, PFAFF, Florian F., ACUÑA-PARÉS, Ferran, DRAKSHARAPU, Apparao, WHITEOAK, Christopher, MARTIN-DIACONESCU, Vlad, LLORET-FILLOL, Julio, BROWNE, Wesley R., RAY, Kallol and COMPANY, Anna (2015). Reactivity of a Nickel(II) Bis(amidate) Complex withmeta-Chloroperbenzoic Acid: Formation of a Potent Oxidizing Species. Chemistry : A European Journal, 21 (42), 15029-15038.