Turega, Simon - Sheffield Hallam University - Department of Biosciences and Chemistry

个人简介

I joined the academic staff at the Sheffield Hallam University in late 2014. After completing my Mchem and PhD degrees at the University of Manchester from there I moved to the University of St Andrews. I left St Andrews to begin work in the Department of Chemistry at the University of Sheffield before taking up my current position. My research interests cover several areas, physical organic chemistry, chemical biology and synthetic chemistry.

研究领域

Molecular recognition Much of my chemistry has involved the study of molecular recognition. Using a selection of synthetic model systems I studied the effect of changing the polarities of hydrogen bond donors and acceptors in my molecules and the solvents they are being studied in. There has been a lot of focus on how individual hydrogen bonds build up to form the type of complex molecular recognition seen in drug receptor interactions. Possibly what is most interesting is the hydrophobic effect where contacts between non hydrogen bonding groups can build up to form a powerful driving force for molecular interactions. Chemical biology I am interested in chemical biology, in molecular recognition and the reversible covalent chemistry that controls gene regulation. This is directed towards the reversible methylation and acetylation of histone lysine residues and the development of small molecule probes to detect and quantify these processes. The work involves the synthesis of small molecules that can be made fluorescent and the observation of these probes in pluripotent cell lines.

近期论文

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“Virtual screening for high affinity guests for synthetic supramolecular receptors”W. Cullen, S. Turega, C. A. Hunter and M D. Ward, Chemical Science, 2015, 6, 2790-2794 “Modulating the electron-transfer properties of a mixed-valence system through host–guest chemistry”A. Zubi, A. Wragg, S Turega, H. Adams, P. J. Costa, V. Félix and J. A. Thomas, Chemical Science, 2015, 6, 1334-1340 “pH-dependent binding of guests in the cavity of a polyhedral coordination cage: reversible uptake and release of drug molecules”W. Cullen, S. Turega, C. A. Hunter and M. D. Ward, Chemical Science, 2015, 6, 625-631 “Mapping the internal recognition surface of an octanuclear coordination cage using guest libraries”S. Turega, W. Cullen, M. Whitehead, C. A. Hunter and M. D. Ward, Journal of the American Chemical Society, 2014, 136, 8475–8483 “Quantification of solvent effects on molecular recognition in polyhedral coordination cage hosts”M. Whitehead, S. Turega, A. Stephenson, C. A. Hunter and M. D. Ward, Chemical Science, 2013, 4, 2744-2751 “Shape-, Size-, and Functional Group-Selective Binding of Small Organic Guests in a Paramagnetic Coordination Cage”S. M. Turega, M. Whitehead, B. R. Hall, A. Meijer, C. A. Hunter and M. D. Ward, Inorganic Chemistry, 2013, 4, 2744–2751