个人简介

Tom Sheppard is currently a Reader in Organic Chemistry focusing on the development of new synthetic methodology for a wide range of potential applications. Current areas of interest include organoboron chemistry, sustainable synthesis, tranisition-metal catalysis, and medicinal chemistry. Tom was appointed as a lecturer in 2007 and at the same time he was awarded an EPSRC Advanced Research Fellowship; he was promoted to Reader in 2013. Prior to taking up his academic appointment, he carried out a PhD with Professor Steve Ley CBE FRS at the University of Cambridge, and was a postdoctoral researcher with Professor William Motherwell FRS at UCL.

研究领域

Organic Chemistry and Chemical Biology

Catalysis: Gold, Palladium, Organocatalysis Organoboron Chemistry Strategically Important Hydration and Dehydration Reactions Novel Scaffolds for Medicinal Chemistry Sustainable Chemistry Drug Discovery: Nicotinic Acetyl Choline Receptors

近期论文

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Higson, S., Subrizi, F., Sheppard, T. D., & Hailes, H. C. (2016). Chemical cascades in water for the synthesis of functionalized aromatics from furfurals. GREEN CHEMISTRY, 18 (7), 1855-1858. doi:10.1039/c5gc02935j Lanigan, R. M., Karaluka, V., Sabatini, M. T., Starkov, P., Badland, M., Boulton, L., & Sheppard, T. D. (2016). Direct amidation of unprotected amino acids using B(OCH2CF3)(3). CHEMICAL COMMUNICATIONS, 52 (57), 8846-8849. doi:10.1039/c6cc05147b Karaluka, V., Lanigan, R. M., Murray, P. M., Badland, M., & Sheppard, T. D. (2015). B(OCH2CF3)(3)-mediated direct amidation of pharmaceutically relevant building blocks in cyclopentyl methyl ether. ORGANIC & BIOMOLECULAR CHEMISTRY, 13 (44), 10888-10894. doi:10.1039/c5ob01801c Foster, R. W., Tame, C. J., Bucar, D. -. K., Hailes, H. C., & Sheppard, T. D. (2015). Sustainable Synthesis of Chiral Tetrahydrofurans through the Selective Dehydration of Pentoses. CHEMISTRY-A EUROPEAN JOURNAL, 21 (45), 15947-15950. doi:10.1002/chem.201503510 Murray, P. M., Bellany, F., Benhamou, L., Bučar, D. K., Tabor, A. B., & Sheppard, T. D. (2015). The application of design of experiments (DoE) reaction optimisation and solvent selection in the development of new synthetic chemistry. Organic and Biomolecular Chemistry, 14 (8), 2373-2384. doi:10.1039/c5ob01892g Dhankher, P., Benhamou, L., & Sheppard, T. D. (2014). Rapid assembly of functionalised spirocyclic indolines by palladium-catalysed dearomatising diallylation of indoles with allyl acetate. Chemistry - A European Journal. doi:10.1002/chem.201403940 D'Oyley, J. M., Aliev, A. E., & Sheppard, T. D. (2014). Regioselective dihalohydration reactions of propargylic alcohols: Gold-catalyzed and non-catalyzed reactions. Angewandte Chemie - International Edition. doi:10.1002/anie.201405348 Sheppard, T. D., Foster, R. W., Benhamou, L., Porter, M. J., Bucar, D. K., Hailes, H. C., & Tame, C. J. (n.d.). Irreversible endo-Selective Diels–Alder Reactions of Substituted Alkoxyfurans: a General Synthesis of endo-Cantharimides. Chemistry - A European Journal. Dunbabin, A., Subrizi, F., Ward, J. M., Sheppard, T. D., & Hailes, H. C. (2017). Furfurylamines from biomass: Transaminase catalysed upgrading of furfurals. Green Chemistry, 19 (2), 397-404. doi:10.1039/c6gc02241c Rota, F., Benhamou, L., & Sheppard, T. D. (2016). Asymmetric Synthesis of Secondary Alcohols and 1,2-Disubstituted Epoxides via Organocatalytic Sulfenylation. Synlett, 27 (1), 33-36. doi:10.1055/s-0035-1560769 Pennell, M. N., Kyle, M. P., Gibson, S. M., Male, L., Turner, P. G., Grainger, R. S., & Sheppard, T. D. (2016). Intercepting the Gold-Catalysed Meyer-Schuster Rearrangement by Controlled Protodemetallation: A Regioselective Hydration of Propargylic Alcohols. ADVANCED SYNTHESIS & CATALYSIS, 358 (9), 1519-1525. doi:10.1002/adsc.201600101 Sheppard, T. D., Benhamou, L., Bucar, D. K., Walker, D., & Aliev, A. E. (2016). Synthesis of substituted benzooxaborinin-1-ols via palladium-catalysed cyclisation of alkenyl- and alkynyl-boronic acids. Organic and Biomolecular Chemistry. doi:10.1039/C6OB01419D Subrizi, F., Cardenas-Fernandez, M., Lye, G. J., Ward, J. M., Dalby, P. A., Sheppard, T. D., & Hailes, H. C. (2016). Transketolase catalysed upgrading of L-arabinose: the one-step stereoselective synthesis of L-gluco-heptulose. GREEN CHEMISTRY, 18 (10), 3158-3165. doi:10.1039/c5gc02660a Gibson, S. M., Lanigan, R. M., Benhamou, L., Aliev, A. E., & Sheppard, T. D. (2015). A lactate-derived chiral aldehyde for determining the enantiopurity of enantioenriched primary amines. ORGANIC & BIOMOLECULAR CHEMISTRY, 13 (34), 9050-9054. doi:10.1039/c5ob01398d Barreiro, E., Sanz-Vidal, A., Tan, E., Lau, S. -. H., Sheppard, T. D., & Diez-Gonzalez, S. (2015). HBF4-Catalysed Nucleophilic Substitutions of Propargylic Alcohols. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (34), 7544-7549. doi:10.1002/ejoc.201501249 Mann, S. E., Benhamou, L., & Sheppard, T. D. (2015). Palladium(II)-Catalysed Oxidation of Alkenes. SYNTHESIS-STUTTGART, 47 (20), 3079-3117. doi:10.1055/s-0035-1560465 Gill-Thind, J. K., Dhankher, P., D'Oyley, J. M., Sheppard, T. D., & Millar, N. S. (2015). Structurally Similar Allosteric Modulators of alpha 7 Nicotinic Acetylcholine Receptors Exhibit Five Distinct Pharmacological Effects. JOURNAL OF BIOLOGICAL CHEMISTRY, 290 (6), 3552-3562. doi:10.1074/jbc.M114.619221 Chatzidaki, A., D'Oyley, J. M., Gill-Thind, J. K., Sheppard, T. D., & Millar, N. S. (2015). The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of alpha 7 nicotinic acetylcholine receptors. NEUROPHARMACOLOGY, 97, 75-85. doi:10.1016/j.neuropharm.2015.05.006 Pennell, M. N., Foster, R. W., Turner, P. G., Hailes, H. C., Tame, C. J., & Sheppard, T. D. (2014). Gold catalysed synthesis of 3-alkoxyfurans at room temperature. Chem Commun (Camb), 50 (11), 1302-1304. doi:10.1039/c3cc48290a D'Oyley, J. M., & Sheppard, T. D. (2014). Halohydration of alkynols: Au-catalyzed and non-catalyzed routes to alpha,alpha-dihalo-beta-hydroxyketones. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 248. AMER CHEMICAL SOC. Aliev, A. E., Kulke, M., Khaneja, H. S., Chudasama, V., Sheppard, T. D., & Lanigan, R. M. (2014). Motional timescale predictions by molecular dynamics simulations: case study using proline and hydroxyproline sidechain dynamics. Proteins, 82 (2), 195-215. doi:10.1002/prot.24350 Sanchez-Vazquez, S. A., Sheppard, T. D., Evans, J. R. G., & Hailes, H. C. (2014). The selective conversion of D-limonene to p,α-dimethylstyrene. RSC Advances, 4 (106), 61652-61655. doi:10.1039/c4ra11558a Sheppard, T. D. (2014). Tris(2,2,2-trifluoroethoxy)boron. In P. L. Fuchs, A. B. Charette (Eds.), Encyclopedia of Reagents for Organic Synthesis, 8 Volume Set. Wiley. doi:10.1002/047084289X.rn01754 Dhankher, P., & Sheppard, T. D. (2013). A Convenient Synthesis of Tri- and Tetramethylbenzaldehydes from Readily Available Phenols. Synlett, 24. doi:10.1055/s-0033-1340302 Ishikawa, S., Sheppard, T. D., D'Oyley, J. M., Kamimura, A., & Motherwell, W. B. (2013). A Rapid Route to Aminocyclopropanes via Carbamatoorganozinc Carbenoids. Angewandte Chemie International Edition, 52 (38), 10060-10063. doi:10.1002/anie.201304720