Stafford, Prachi - Sheffield Hallam University - Department of Biosciences and Chemistry

个人简介

I was appointed lecturer in Biological Sciences at Sheffield Hallam University in 2015. Prior to that, I completed my BSc (Hons) in Pharmacology at the University of Sheffield, a Masters in Research (MRes) in Biomolecular Science at the University of York and a PhD in Haematology/Immunology at the Department of Haematology, University of Cambridge. At Sheffield Hallam University, I teach both undergraduate and postgraduate students on a range of courses including and at all levels. I am also an active researcher with an interest in host-pathogen interactions and the possible implications of chronic infections in systemic diseases.

研究领域

My general interests lie in understanding the mechanisms underlying host-pathogen interactions and how these can exacerbate and/or contribute to systemic conditions. My current work focusses on the periodontal pathogens Tannerella forsythia and Porphyromonas gingivalis. Both pathogens have been linked to periodontitis (a chronic inflammatory disease resulting in bleeding gums and tooth loss) and have also been implicated in aggravating systemic diseases including cardiovascular disease (atherosclerosis & atherothrombosis), rheumatoid arthritis and diabetes.

近期论文

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P Stafford, SF Garner, E Huiskes, C Kaplan, R Kekomaki, N Tsuno, S Santoso, NA Watkins, WH Ouwehand, (2008). Three novel beta3 domain-deletion peptides for the sensitive and specific detection of HPA-4 and six low frequency beta-3-HPA antibodies. Journal of Thrombosis and Haemostasis, 6(2):376-383 NAYLOR, K L, WIDZIOLEK, M, HUNT, S, CONNOLLY, M, HICKS, M, STAFFORD, Prachi, POTEMPA, J, MURDOCH, C, DOUGLAS, C W I and STAFFORD, G P (2016). Role of OmpA2 surface regions of Porphyromonas gingivalis in host-pathogen interactions with oral epithelial cells. Microbiology Open. (In Press) HAKAMI, F, DARDA, L, STAFFORD, Prachi, WOLL, P, LAMBERT, D W and HUNTER, K D (2014). The roles of HOXD10 in the development and progression of head and neck squamous cell carcinoma (HNSCC). British journal of cancer, 111 (4), 807-16. STAFFORD, P, HIGHAM, J, PINNOCK, A, MURDOCH, C, DOUGLAS, C W I, STAFFORD, G P and LAMBERT, D W (2013). Gingipain-dependent degradation of mammalian target of rapamycin pathway proteins by the periodontal pathogen Porphyromonas gingivalis during invasion. Molecular oral microbiology, 28 (5), 366-378. ROY, Sumita, PHANSOPA, Chatchawal, STAFFORD, Prachi, HONMA, Kiyonobu, DOUGLAS, C W Ian, SHARMA, Ashu and STAFFORD, Graham P (2012). Beta-hexosaminidase activity of the oral pathogen Tannerella forsythia influences biofilm formation on glycoprotein substrates. FEMS Immunology and Medical Microbiology, 65 (1), 116-120.