Princivalle, Alessandra - Sheffield Hallam University - Department of Biosciences and Chemistry

研究领域

The project aims to study the heterogeneity in temporal lobe epilepsy (TLE) patients who are resistant to drug therapy and undergo surgical treatment. There is currently no understanding of the molecular basis of such resistance and no valid criteria to guide a therapeutic strategy. A microarray technique is being employed to identify molecular substrates which we can then investigate further. This work is in collaboration with Drs F. Falciani (Bioscience, University of Birmingham) and M.Reuber and Dev Bhattacharyya (Royal Hallamshire Hospital, Sheffield). Other studies are focused on generation and characterisation of an antibody that recognises the human serotoninergic 5-HT3B receptor to further clarify the involvement of 5-HT3 receptor in epilepsy, which is suggested to have an excitatory role in the kindling model of epilepsy. This work is in collaboration with Dr NM Barnes (head of neuropharmacology, University of Birmingham). Further collaboration with Professor T Marson, Dr N Mirza (University of Liverpool) and Dr M Rueber (Royal Hallamshire Hospital, Sheffield) in a project on the role of multidrug transporter causing drug resistance in human epilepsy.

近期论文

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PRINCIVALLE, Alessandra, PARKER, Rachel M., DOVER, Terri J. and BARNES, Nicholas M. (2012). Detection of mRNA encoding receptors by in situ and northern hybridization. In: DAVENPORT, Anthony P., (ed.) Receptor binding techniques. Methods in Molecular Biology (897). Springer, 261-302. TRIM, P. J., ATKINSON, S. J., PRINCIVALLE, A. P., MARSHALL, P. S., WEST, A. and CLENCH, M. R. (2008). Matrix-assisted laser desorption/ionisation mass spectrometry imaging of lipids in rat brain tissue with integrated unsupervised and supervised multivariant statistical analysis. Rapid Communications in Mass Spectrometry, 22 (10), 1503-1509. TRIM, P. J., HENSON, C. M., AVERY, J. L., MCEWEN, A., SNEL, M. F., CLAUDE, E., MARSHALL, P. S., WEST, A., PRINCIVALLE, A. P. and CLENCH, M. R. (2008). Matrix-assisted laser desorption/ionization-ion mobility separation-mass spectrometry imaging of vinblastine in whole body tissue sections. Analytical chemistry, 80 (22), 8628-8634. CHANDLER, K. E., PRINCIVALLE, A. P., FABIAN-FINE, R., BOWERY, N. G., KULLMANN, D. M. and WALKER, M. C. (2003). Plasticity of GABAB receptor-mediated heterosynaptic interactions at mossy fibers after status epilepticus. Journal of neuroscience, 23 (36), 11382-11391. PRINCIVALLE, A. P., DUNCAN, J. S., THOM, M. and BOWERY, N. G. (2003). GABAB1a, GABAB1b AND GABAB2 mRNA variants expression in hippocampus resected from patients with temporal lobe epilepsy. Neuroscience, 122 (4), 975-984. PRINCIVALLE, A. P., RICHARDS, D. A., DUNCAN, J. S., SPREAFICO, R. and BOWERY, N. G. (2003). Modification of GABAB1 and GABAB2 receptor subunits in the somatosensory cerebral cortex and thalamus of rats with absence seizures (GAERS). Epilepsy research, 55 (1-2), 39-51. PRINCIVALLE, A. P., DUNCAN, J. S., THOM, M. and BOWERY, N. G. (2002). Studies of GABAB receptors labelled with [3H]-CGP62349 in hippocampus resected from patients with temporal lobe epilepsy. British journal of pharmacology, 136 (8), p. 1099.