Peake, Nicholas - Sheffield Hallam University - Department of Biosciences and Chemistry

个人简介

I was awarded a PhD from the University of Newcastle in 2005 in the field of inflammatory rheumatology, followed by 10 years of postdoctoral research in Toronto, Southampton and London. This has focussed on inflammation - mainly in the context of musculoskeletal diseases - and extracellular matrix biology as a result of inflammatory disease and cancer. I moved to Sheffield Hallam in 2015 as a lecturer in Biomedical Sciences.

研究领域

My research interests are focused on the relationship between the extracellular matrix that provides structural support to cellular tissues, and the processes that contribute to disease. My particular focus is on mechanisms connecting inflammatory activation and tissue damage to the progression of cancer and musculoskeletal conditions. Inflammation and tissue remodelling in colorectal cancer: As disease progresses, cancers remodel their environment in order to invade and spread into surrounding tissues. Cancer cells are also highly responsive to their environment, making this interaction crucial in determining disease outcome. My work has identified that the enzyme Transglutaminase-2 is prominently expressed in the tissue surrounding colorectal tumours, and that it has pro-inflammatory and tissue remodeling functions. My current research is studying these roles in 3D cell culture models of colorectal cancer, and investigating whether novel technologies can be developed to modulate enzyme activity and therefore the progress of disease. Protecting cartilage from inflammatory musculoskeletal disease: My recent work has involved research into mechanisms connecting inflammation to cartilage breakdown in Osteoarthritis, and I have studied how this breakdown can be prevented by movement and the protective peptide, CNP. This has involved multiple approaches focused on promoting the beneficial effects of CNP, and include examining epigenetic regulation, investigating the impact of ageing on CNP function, and developing novel technologies for the delivery of CNP to sites where it could promote tissue repair. My current research is investigating ways to optimise these beneficial effects in musculoskeletal disease.

近期论文

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Peake NJ, Bader DL, Vessillier S, Ramachandran M, Salter DM, Hobbs AJ, Chowdhury TT. C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes. Biochem Biophys Res Commun 2015: 465, 784-9. Cellura D, Pickard K, Quaratino S, Parker H, Strefford J, Thomas G, Ritter R, Mirnezami A, Peake NJ. Mir-19a-mediated loss of tissue transglutaminase leads to enhanced invasion and metastasis of colon cancer cells. Mol Cancer Res 2015: 13, 1095-105. Peake N, Pavlov AM, D’Souza A, Pingguan-Murphy B, Sukhurukov G, Hobbs AJ, Chowdhury TT. Controlled Delivery of C-type Natriuretic Peptide by microencapsulation dampens inflammatory signaling induced by IL-1β in wounded cartilage explants. BioMacromolecules 2015: 16, 524-31. Peake N, Pingaan-Murphy B, Hobbs AJ and Chowdhury TT. Role of natriuretic peptide signaling in maintaining cartilage and bone function. Osteoarthritis & Cartilage 2014: 22, 1800-7. Peake N, Su N, Ramachandran M, Achan P, Bader DL, Salter DM, Moyes AJ, Hobbs AJ and Chowdhury TT. Natriuretic peptide receptors regulate cytoprotective effects in an ex vivo human 3D/bioreactor model. Arthritis Research & Therapy 2013: 15, R76. Luciano A, Villella V, Vasaturo A, Giardino I, Pettoello-Mantovani M, Guido S, Cexus O, Peake N, Londei M, Quaratino S, Mauiri L. Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and Tissue Transglutaminase mediated PPARgamma downregulation in intestinal epithelial cells and celiac mucosa. Gut 2010: 59, 311-9.