Miller, Keith - Sheffield Hallam University - Department of Biosciences and Chemistry

个人简介

Keith was appointed as a lecturer at Sheffield Hallam University after completing a BSc and a PhD in Medical Microbiology at the University of Leeds. Also at the University of Leeds, he completed three post-doctoral research fellowships funded by the Department of Health, Novartis and the MRC. During his teaching career at Sheffield Hallam he has taught microbiology and biochemistry and is the course leader for MSc Biomedical Sciences and MSc Biomedical Laboratory Sciences. He is a Fellow of the Higher Education Academy and a member of both the American Society for Microbiology and the British Society for Antimicrobial Chemotherapy

研究领域

Keith's research group is interested in all areas of antimicrobial chemotherapy research. We are investigating new sources of antimicrobial agents including snake and scorpion venom, deep sea corals and novel synthetic drug scaffolds. We are trying to identify and characterise the interactions between drugs and their targets at a molecular level. We are researching genetic and proteomic mechanisms of antimicrobial resistance found here in the UK and in the developing world. We are developing novel antimicrobial wound dressing with a broad range of applications. Natural product antimicrobial drug discovery The current development gap for novel antimicrobial agents has been well documented. The development of natural products and natural product derivatives has been a rich source of antibiotics in the past and is an area that has been proposed for the development of novel drug development candidates. Peptide antimicrobials from organisms lacking an adaptive immune system and complex organic molecules from natural sources are a relatively underexploited natural product reservoir. These projects seek to establish the mechanism of action of previously identified and purified antimicrobial peptides from snake venoms, scorpion venoms and organic scaffolds from other natural product reservoirs. Development of antibiotic-resistance Antibiotic-resistance is an important problem in the management of infectious disease and a major barrier to market-based development of novel antimicrobials. It is important to understand the mechanisms of antimicrobial resistance and the distribution of these mechanisms worldwide. One study conducted here in the BMRC seeks to quantify and characterise carbapenemase resistance determinants in Gram-negative pathogens isolated in three hospitals in the Accra area of Ghana. The rate of carriage, the specific genotypes and the associations with patient information will be determined and assessed for clinical impact.

近期论文

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HARRISON, Patrick L., HEATH, George R., JOHNSON, Benjamin R.G., ABDEL-RAHMAN, Mohamed A., STRONG, Peter, EVANS, Stephen D. and MILLER, Keith (2016). Phospholipid dependent mechanism of smp24, an α-helical antimicrobial peptide from scorpion venom. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1858 (11), 2737-2744. HARRISON, Patrick L., ABDEL-RAHMAN, Mohamed A., STRONG, Peter, TAWFIK, Mohamed M. and MILLER, Keith (2016). Characterisation of three alpha-helical antimicrobial peptides from the venom of Scorpio maurus palmatus. Toxicon, 117, 30-36. HARRISON, Patrick L, ABDEL-RAHMAN, Mohamed, MILLER, Keith and STRONG, Peter (2014). Antimicrobial peptides from scorpion venoms. Toxicon, 88, 115-137. KHAN, Akram, MILLER, Keith, RAINSFORD, Kim and ZHOU, Yong (2013). Synthesis and Antimicrobial Activity of Novel Substituted Ethyl 2-(Quinolin-4-yl)-propanoates. Molecules, 18 (3), 3227-3240. KHAN, M., MILLER, Keith, RAINSFORD, Kim and ZHOU, Yong (2013). Synthesis and antimicrobial activity of novel substituted Ethyl 2-(Quinolin-4-yl)-propanoates. Molecules, 18 (3), 3227-3240. MILLER, K., DUNSMORE, C. J., LEEDS, J. A., PATCHING, S. G., SACHDEVA, M., BLAKE, K. L., STUBBINGS, W. J., SIMMONS, K. J., HENDERSON, P. J. F., DE LOS ANGELES, J., FISHWICK, C. W. G. and CHOPRA, I. (2010). Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ). Journal of Antimicrobial Chemotherapy, 65 (12), 2566-2573. MARINER, K R, TROWBRIDGE, R, AGARWAL, A K, MILLER, Keith, O'NEILL, A J, FISHWICK, C W and CHOPRA, I (2010). Furanyl-rhodanines are unattractive drug candidates for development as inhibitors of bacterial RNA polymerase. Antimicrobial Agents and Chemotherapy, 54 (10), 4506-4509. OOI, N, MILLER, Keith, RANDALL, C, RHYS-WILLIAMS, W, LOVE, W and CHOPRA, I (2010). XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms. Journal of Antimicrobial Chemotherapy, 65 (1), 72-78. OOI, N., MILLER, K., HOBBS, J., RHYS-WILLIAMS, W., LOVE, W. and CHOPRA, I. (2009). XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity. Journal of Antimicrobial Chemotherapy, 64 (4), 735-740.