Khan, Akram - Sheffield Hallam University - Department of Biosciences and Chemistry

个人简介

After completing my BSc in chemistry, MSc by research in electro-organic synthesis and PhD in organic synthesis at the University of Sheffield I joined the University of Kuwait as an assistant lecturer in chemistry. After that I got appointed to my present position as senior lecturer in organic chemistry at Sheffield Hallam University (Sheffield Polytechnic). My research interests are in synthesis of novel drugs for the treatment of rheumatoid arthritis, cancer, malaria and bacterial conditions.

研究领域

The synthesis of novel quinoline compounds with potential anti-malarial activity. Malaria parasites are transmitted to humans by the bite of infected female mosquitoes of more than 30 anopheline species. Globally, an estimated 3.3 billion people were at risk of malaria in 2011, with populations living in sub Saharan Africa having the highest risk of acquiring malaria: approximately 80% of cases and 90% of deaths are estimated occur in the WHO African Region, with children under five years of age and pregnant women most severely affected (WHO, 2012). New antimalarial compounds are desperately needed to treat malaria. carbocyclic derivatives of quinine can be made in the laboratory and these may offer better activity as antimalarials. The synthesis of these compounds involves making various substituted quinoline-4-carboxaldehydes and then reacting them with acrylates in Baylis-Hillman reaction and then reacting these products with dienes using the Diels-Alder reaction to produce the products as potential anti-malarials. Synthesis of mustard containing curcumins as potential anticancer agents Curcumin is a yellow naturally occurring polyphenolic compound, which has been traditionally used in medicine for the treatment of different health problems, such as asthma, allergy, acne, diabetic wounds and ulcer. It also has a potential cancer chemopreventive and antiproliferative activity against almost all types of cancers by inhibiting all three steps of the tumorigenesis process. The aim of this project would be to synthesise a novel nitrogen mustard curcumin by a multistep synthesis. The synthesised curcumins will be purified by flash column chromatography and analysed by TLC and characterised spectroscopically by IR,1H NMR and 13C NMR spectroscopies and ELS-MS spectrometry.

近期论文

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M.S. Abaza, M.A. Khan, and M. Afzal, "Chemistry, Biochemistry and Selective Cytotoxicity of Curcumin Analogues Against Human Cancer Cell Lines" in Curcumin : Biosynthesis, Medicinal Uses and Health Benefits, Editors: Jun Sasaki and Masaki Kichida, 2012, Nova Science Publishers Inc., N.Y. M. Akram Khan; K. Miller; Kim D. Rainsford; and Yong Zhou. " Synthesis of Novel Substituted Ethyl 2-(quinolin-4-yl)propanoates and their Anti-microbial Activity against Helicobacter Pylori", Molecules, 2013, 18, 3227-3240; doi:10.3390/molecules18033227. KHAN, Akram and AFZAL, M (2016). Chemical composition of Nigella sativa Linn : Part 2 Recent advances. Inflammopharmacology, 24 (2), 67-79. SÖKMEN, Münevver and KHAN, Akram (2016). The antioxidant activity of some curcuminoids and chalcones. Inflammopharmacology, 24 (2), 81-86. AFZAL, A, ORIQAT, G, KHAN, Akram, JOSE, J and AFZAL, M (2013). Chemistry and biochemistry of Terpenoids from Curcumaand related species. Journal of Biologically Active Products from Nature, 3 (1), 1-55.