Jordan-Mahy, Nikki - Sheffield Hallam University - Department of Biosciences and Chemistry

个人简介

Nikki was appointed as a Senior Lecturer at Sheffield Hallam University after completing a BSc Hons in Physiology and Zoology at Royal Holloway and Bedford New College, at the University of London and a PhD at Cambridge University at the MRC Dunn Nutrition Unit. She has taught in many areas including physiology, anatomy, embryology, pathology, forensic pathology and nutrition. She is a member of the Cancer Research Group and the Musculoskeletal and Regenerative Medicine Research Group in the Biomolecular Research centre (BMRC). Nikki supervises PhD students in these two research areas.

研究领域

The use of polyphenols in the treatment of leukaemia and their impact on standard chemotherapy treatments. This work is in collaboration with Dr Gordon McDougall from the James Hutton Institute and members of the BMRC. Investigating the use of Novel 3D Cell culture method for the study and treatments of small intestinal inflammatory disease. This research is in collaboration with Dr Christine Le Maitre from the BMRC and Professor Chris Salmon from MERI. This collaboration has enabled a more materialistic approach to gastrointestinal research. Epithelial regenerative medicine research This research is in collaboration with Dr Christine Le Maitre from the BMRC and Dr Andrew Allison from MERI and Dr Prasad Godbole. Use of nutraceuticals in the treatment of leukaemia Generation of novel 3D cell culture model for the study of gastrointestinal disease Epithelial regenerative medicine research Cancer research collaborators include Dr Gordon McDougall from the James Hutton Institute and Dr Neil Cross, Dr Sarah Haywood and Dr Christine Le Maitre from the BMRC. This work has been funded and sponsored by the Saudi Arabian Government. Regenerative gastrointestinal medicine research is in collaboration with Dr Christine Le Maitre from the BMRC and Professor Chris Salmon from MERI. This work is funded and sponsored by the Iraq Government. Epithelial regenerative medicine research is in collaboration with Dr Christine Le Maitre from the BMRC, Dr Andy form MERI and Dr Prasad Godbole and Dr Andrew Alderson.

近期论文

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MAHBUB, A.A., LE MAITRE, C.L., HAYWOOD-SMALL, S.L., CROSS, N.A. and JORDAN-MAHY, N. (2015). Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines. Cell Death and Disease, 6, e2028. MAHBUB, A A, LE MAITRE, Christine, HAYWOOD-SMALL, Sarah, CROSS, N A and JORDAN-MAHY, Nikki (2015). Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines. Cell Death Discovery, 1, p. 15043. MAHBUB, A.A., LE MAITRE, C.L., HAYWOOD-SMALL, S.L., CROSS, N.A. and JORDAN-MAHY, N. (2015). Polyphenols act synergistically with doxorubicin and etoposide in leukaemia cell lines. Cell Death Discovery, 1 (15043), 1-12. DAHLAWI, H, JORDAN-MAHY, Nikki, CLENCH, Malcolm and LE MAITRE, Christine (2012). Bioactive actions of pomegranate fruit extracts on leukemia cell lines In vitro hold promise for new therapeutic agents for leukemia. Nutrition and Cancer, 64 (1), 100-110. MCDOUGALL, G. J., DOBSON, P. and JORDAN-MAHY, N. (2010). Effect of different cooking regimes on rhubarb polyphenols. Food chemistry, 119 (2), 758-764. PHILLIPS, KL, JORDAN-MAHY, N, NICKLIN, MJ, LE MAITRE, CL (2013). Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration Ann Rheum Dis. Nov;72(11):1860-7. DAHLAWI, H, JORDAN-MAHY, N, CLENCH, M, MCDOUGALL, GJ, MAITRE, CL (2013). Polyphenols are responsible for the pro-apoptotic properties of pomegranate juice on leukaemia cell lines Food Sci Nutr. Mar; 1(2):196-208.