Hamilton, Alex - Sheffield Hallam University - Department of Biosciences and Chemistry

个人简介

I was appointed as a lecturer in Physical Chemistry at Sheffield Hallam University after completing my MChem in Chemistry as Swansea University, a PhD in Structural Chemistry at Bristol University and postdoctoral stays in Spain (ICIQ) and New Zealand (Massey University). My teaching covers all aspects of Physical Chemistry. My research group apply state-of-the-art computational simulations to understand reaction mechanisms and design novel catalysts.

研究领域

Catalyst design through database mining and computational chemistry Organometallic homogeneous catalysis is the workhorse of fine chemical synthesis. The shear variety and high level of tunability means these catalytic complexes have found application in pharmaceuticals, agrochemicals manufacture and beyond. Even with all the interest in organometallic complexes, the holy grail of 'designer catalysts' is still some way off. Hemi-labile ligands are particularly interesting as, due to their inherent flexibility, they have the ability to control the number of coordination sites around the metal centre. Understanding and manipulating this flexibility can lead to new reaction pathways and novel products. Elucidation of catalytic reactions mechanisms In collaboration with a number of external research groups we have an interest in solving the complex mechanisms involved in catalysis, both organo- and transition metal orientated. Reactions of interest are, but not limited to, C-H activation, hydrogenation and hydrocyanation. Non-covalent interactions in supramolecular chemistry Supramolecular chemistry finds application in wide and diverse areas of chemistry, biology, materials and environmental science. The understanding of the non-covalent interactions which govern the structure and activity of the supramolecular species is key to optimising their application. We have particular interest in systems applied to catalysis and chemical sensing.

近期论文

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LISTER, Julia M., CARREIRA, Monica, HADDOW, Mairi F., HAMILTON, Alex, MCMULLIN, Claire L., ORPEN, A. Guy, PRINGLE, Paul G. and STENNETT, Tom E. (2014). Unexpectedly high barriers to M–P rotation in tertiary phobane complexes : PhobPR behavior that is commensurate with tBu2PR. Organometallics, 33 (3), 702-714. OWEN, Gareth R, GOULD, P Hugh, MOORE, Alexandra, DYSON, Gavin, HADDOW, Mairi F and HAMILTON, Alexander (2013). Copper and silver complexes bearing flexible hybrid scorpionate ligand mpBm. Dalton Transactions, 42 (31), 11074-11081. MORAN, Antonio, HAMILTON, Alexander, BO, Carles and MELCHIORRE, Paolo (2013). A mechanistic rationale for the 9-amino(9-deoxy)epi cinchona alkaloids catalyzed asymmetric reactions via iminium ion activation of enones. Journal of the American Chemical Society, 135 (24), 9091-9098. TSOUREAS, Nikolaos, HAMILTON, Alexander, HADDOW, Mairi F., HARVEY, Jeremy N., ORPEN, A. Guy and OWEN, Gareth R. (2013). Insight into the hydrogen migration processes involved in the formation of metal–borane complexes : importance of the third arm of the scorpionate ligand. Organometallics, 32 (9), 2840-2856. HAMILTON, Alex, GICQUEL, Michael, BALLESTER, Pablo and BO, Carles (2013). Mechanisms of catalysis in confined spaces: hydrogenation of norbornadiene with a rhodium complex included in a self-folding cavitand. Current Organic Chemistry, 17 (14), 1499-1506.