Haddock, Gail - Sheffield Hallam University - Department of Biosciences and Chemistry

个人简介

I was appointed as a lecturer at Sheffield Hallam University after completing a PhD, followed by a 5 year post-doctoral position in Neuroscience at Sheffield Hallam University. I teach a wide range of subjects including anatomy and physiology, cell biology and biochemistry. My main research area is Neuroimmunology with specific interest in Multiple sclerosis.

研究领域

Multiple sclerosis (MS) is a chronic inflammatory, neurodegenerative disease of the central nervous system (CNS) affecting mainly white matter. Key events in the pathogenesis of MS include breakdown of the blood-brain barrier, resulting infiltration of inflammatory cells leading (directly or indirectly) to changes in the composition of the ECM. The extracellular matrix proteins are important to brain structure through maintenance of the correct hydrodynamics and in their interactions with other ECM components.The sequence of events leading to changes in the ECM of white matter in MS are not known, nor are the enzymes that are responsible for these processes which ultimately lead to axonal loss. Alterations in turnover of the ECM contribute to disease processes and are modulated by injury. ADAMTS-1, -4 and -5 have been shown to cleave aggregating chondroitin sulphate proteoglycans (CSPGs) such as aggrecan, versican and brevican which are key components of CNS ECM. We wish to investigate the roles played in this process by the ADAMTS group.

近期论文

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PHILLIPS, Kate L.E., CHIVERTON, Neil, MICHAEL, Anthony L.R., COLE, Ashley A, BREAKWELL, Lee M, HADDOCK, Gail, BUNNING, Rowena A.D., CROSS, Alison K. and LE MAITRE, Christine L. (2013). The cytokine and chemokine expression profile of nucleus pulposus cells: implications for degeneration and regeneration of the intervertebral disc. Arthritis research & therapy, 15 (6), R213. REID, M. J., CROSS, A. K., HADDOCK, G., ALLAN, S. M., STOCK, C. J., WOODROOFE, M. N., BUTTLE, D. J. and BUNNING, R. A. D. (2009). ADAMTS-9 expression is up-regulated following transient middle cerebral artery occlusion (tMCAo) in the rat. Neuroscience letters, 452 (3), 252-257. HADDOCK, G., CROSS, A. K., ALLAN, S., SHARRACK, B., CALLAGHAN, J. T., BUNNING, R. A., BUTTLE, D. J. and WOODROOFE, M. N. (2007). Brevican and phosphacan expression and localization following transient middle cerebral artery occlusion in the rat. Biochemical Society Transactions, 35 (4), p. 692. CROSS, A. K., HADDOCK, G., STOCK, C. J., ALLAN, S., SURR, J., BUNNING, R. A., BUTTLE, D. J. and WOODROOFE, N. (2006). ADAMTS -1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes. Brain research, 1088 (1), 19-30. CROSS, A. K., HADDOCK, G., SURR, J., PLUMB, J., BUTTLE, D. J. and WOODROOFE, N. (2005). Differential expression of ADAMTS -1, -4, -5 and TIMP -3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis. Journal of autoimmunity, 26 (1), 16-23.