Forbes, Sarah - Sheffield Hallam University - Department of Biosciences and Chemistry

个人简介

I was appointed as a lecturer at Sheffield Hallam University after completing a BSc and PhD in microbiology at The University of Manchester. My research is focused within the fields of antimicrobial chemotherapy and microbial ecology. I have taught both undergraduate and postgraduate students on microbiology and immunology programs.

研究领域

Combinatorial effects of biocides and quorum sensing inhibitors in medical device related pathogens. The microbial contamination of biomedical devices is a primary cause of hospital-acquired infection and causes major medical and economic burden. With an ageing population it is likely that the need for implantable biomedical devices will continue to rise, resulting in an increasing threat of difficult to treat device-associated infections to the populous and an increasing economic strain on healthcare service providers. My research focuses on the use of biocides and quorum sensing inhibitors to inhibit the establishment of bacterial biofilms on device surfaces and prevent device-associated infections. Small colony variant formation in Staphylococcus aureus after long-term biocide exposure. Staphylococcus aureus is an important human pathogen that is responsible for a range of hospital and community-acquired infections. Successful treatment of such infections is complicated by the generation of antimicrobial insusceptible small-colony variants (SCVs). My research aims to evaluate the generation of S. aureus SCVs after exposure to the biocide triclosan and to characterize any phenotypic consequences that occur as a result of this adaptation. In vitro modelling and characterization of bacterial biofilm communities. Bacterial biofilms are spatially structured communities whose function is dependent on a complex web of symbiotic interactions. Biofilms are found both within the human body and the natural environment and often display a high level of recalcitrance to antimicrobial therapy. I use in vitro biofilm models to mimic real life bacterial communities and evaluate antimicrobial treatment regimes.

近期论文

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Forbes S, Knight CG, Cowley C, Amézquita A, McClure P and McBain AJ (2016). Variable Effects of Exposure to Formulated Microbicides on Antibiotic Susceptibility in Firmicutes and Proteobacteria. Applied and Environmental Microbiology 00701-16. Forbes S, Latimer J and McBain AJ (2016). Simultaneous Assessment of Acidogenesis-Mitigation and Specific Bacterial Growth-Inhibition by Dentifrices. PloS one 11:e0149390. Latimer J, Munday J, Buzza K, Forbes S and McBain AJ (2015) Antibacterial and Anti-biofilm Activity of Mouthrinses Containing Cetylpyridinium chloride and Sodium fluoride. BMC microbiology 15:169. Cowley N, Forbes S (co-first author), Humphreys G, Amézquita A, McClure P, McBain AJ (2015) Effects of Formulation on Microbicide Potency and Mitigation of the Development of Bacterial Insusceptibility. Applied and Environmental Microbiology 81:4809-4816. Forbes S, Latimer J and McBain AJ (2015) A Triclosan-Induced Small Colony variant of Staphylococcus aureus Displays Altered Cellular Morphology, Reduced Competitive Fitness and Increased Antibiotic Susceptibility. Antimicrobial Agents and Chemotherapy 59:4809-16. Forbes S, Humphreys GJ and McBain AJ (2014). Transient and Sustained Bacterial Adaptation Following Repeated Sub-lethal Exposure to Microbicides and a Novel Human Antimicrobial Peptide. Antimicrobial Agents and Chemotherapy. 58:5809-5817.