Duckett, Catherine - Sheffield Hallam University - Department of Biosciences and Chemistry

个人简介

Catherine became a Senior Lecturer at Sheffield Hallam in January 2013, and part of the Bioanalytical Research Group in the BMRC. Her research is focussed on drug metabolism and analytical procedures used to develop novel pharmacological and biomedical molecules, with a particular emphasis on ICPMS methodologies including imaging. She teaches undergraduate and postgraduate students across the Chemistry, Biochemistry and Forensic Science degree programmes. She holds a BSc (Hons) Chemistry, a PhD from Imperial College London, and a Postgraduate Certificate in Teaching Learning from Keele University. She also holds FHEA, CChem and CSci status

研究领域

Analysis of Biomolecules using ICPMS Examples of projects in these areas are a) Metal homeostasis phosphorylation and the aggregation of alpha-synuclein - with Dr David Smith and Dr Caroline Dalton b) Studies into the uptake and distribution of metal oxide nanoparticles in plants – with Professor Malcolm Clench and Professor Neil Bricklebank in collaboration with Croda c) Imaging the transport and biotransformation of molecules across biological membranes - with Professor Malcolm Clench and Professor Neil Bricklebank in collaboration with Croda and Quotient

近期论文

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Duckett CJ, McCullagh M, Smith CJ, Wilson ID. Xenobiotica. 2015; Apr 1-9 e-published ahead of print. ISSN: 0049-8254 (print), 1366-5928 (electronic) 'The metabolism of 4-bromoaniline in the bile-cannulated rat: application of ICPMS (79/81Br), HPLC-ICPMS & HPLC-oaTOFMS' Thompson DF, Michopoulos F, Smith CJ, Duckett CJ, Wilkinson RW, Jarvis P, Wilson ID. Mol. BioSyst. 2011; 7: 1149-1157. ‘Profiling biological samples using ultra performance liquid chromatography-inductively coupled plasma-mass spectrometry (UPLC-ICP-MS) for the determination of phosphorus and sulfur-containing metabolites’ Thompson DF, Eboroll W, Dinsmore A, Smith CJ, Duckett CJ. Rapid. Comm. Mass Spect. 2010; 24 (7): 927-932. ‘Development and validation of a NANOGoldTM immunoassay for the detection of vascular endothelial growth factor (VEGF) in human serum using inductively coupled plasma mass spectrometry’ GRIFFIN, Lizzie, COX, Michael and DUCKETT, Catherine (2016). Trace 56Fe, 63/65Cu and 64Zn metal analysis in whole blood by SEC-HPLC-ICPMS. Chromatography Today, 9 (3), 32-34. DUCKETT, Catherine, MCCULLAGH, Michael, SMITH, Christopher and WILSON, Ian D (2015). The metabolism of 4-bromoaniline in the bile-cannulated rat: application of ICPMS (79/81Br), HPLC-ICPMS & HPLC-oaTOFMS. Xenobiotica, 45 (8), 672-680. THOMPSON, David F., MICHOPOULOS, Filippos, SMITH, Christopher J., DUCKETT, Catherine, WILKINSON, Robert W., JARVIS, Philip and WILSON, Ian D. (2013). Phosphorus and sulfur metabonomic profiling of tissue and plasma obtained from tumour-bearing mice using ultra-performance liquid chromatography/inductively coupled plasma mass spectrometry. Rapid Communications in Mass Spectrometry, 27 (22), 2539-2545. Duckett CJ, Wilson ID, Douce DS, Walker HJ, Abou-Shakra FR, Lindon JC, Nicholson JK. Xenobiotica. 2007; 37 (12): 1389-1393. ‘Metabolism of 2-fluoro-4-iodoaniline in earthworm Eisenia veneta using 19F-NMR spectroscopy, HPLC-MS, and HPLC-ICPMS (127I) Athersuch TJ, Duckett CJ, Castro-Perez J, Wilson ID, Nicholson JK. Xenobiotica. 2007; 37 (1): 44-58. ‘The metabolism of [14C]-5-chloro-1,3-benzodioxol-4-amine in male, bile cannulated, Wistar-derived rats following i.p/dosing at 25 mg/kg’