Dalton, Caroline - Sheffield Hallam University - Department of Biosciences and Chemistry

研究领域

Pharmacogenetics Study of functional polymorphisms in the family of 5-HT receptor genes. These polymorphisms may affect gene expression in certain groups of psychiatric patients and therefore affect their response to drug treatment. The current study is focussed on genotyping patients for the various polymorphisms, and relating the genotypes to mRNA and protein expression using real-time PCR, binding assays and reporter gene assays in mammalian cell lines. This work is in collaboration with Dr Adrian Hall and is part of a long-standing association with Professor Gavin Reynolds of Queen's University, Belfast. Neurodegeneration This work has focussed on the developed a cell culture model of CAG repeat diseases, which can be used to study the mechanisms of these disease, in particular the differences in vulnerability of affected neuronal cells to mitochondrial toxins. This has been applied to the investigation of the effect of polyunsaturated fatty acids and antioxidants on neurodegeneration in neuroblastoma cells. Further studies are concentrating on investigating the potential neuroprotective effects of selenium. This work is in collaboration with Dr Philip Gardiner.

近期论文

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MASON, Rebecca, PASKINS, Aimee, DALTON, Caroline and SMITH, David (2016). Copper Binding and Subsequent Aggregation of α-Synuclein Are Modulated by N-Terminal Acetylation and Ablated by the H50Q Missense Mutation. Biochemistry, 55 (34), 4737-4741. FACHIM, Helenne, SRISAWAT, Umarat, DALTON, Caroline, HARTE, Michael K, MARSH, Samuel, NEILL, Joanna C and REYNOLDS, Gavin (2016). Subchronic administration of phencyclidine produces hypermethylation in the parvalbumin gene promoter in rat brain. Epigenomics, 8 (9), 1179-1183. ROCHA, Joel, PAXMAN, Jenny, DALTON, Caroline, WINTER, Edward and BROOM, David (2016). Effects of a 12-week aerobic exercise intervention on eating behaviour, food cravings and 7-day energy intake and energy expenditure in inactive men. Applied Physiology, Nutrition and Metabolism, 41 (11), 1129-1136. ILLANGASEKERA, Yasitha A., KUMARASIRI, Ranjith P.V., FERNANDO, Devaka J. and DALTON, Caroline (2016). Association of FTO and near MC4R variants with obesity measures in urban and rural dwelling Sri Lankans. Obesity Research & Clinical Practice. (In Press) ILLES-TOTH, Eva, RAMOS, Mafalda, CAPPAI, Roberto, DALTON, Caroline and SMITH, David (2015). Distinct higher-order alpha-synuclein oligomers induce intracellular aggretation. Biochemical Journal, 468 (3), 485-493. ROCHA, Joel, PAXMAN, Jenny, DALTON, Caroline, WINTER, Edward and BROOM, David (2015). Effects of an acute bout of aerobic exercise on immediate and subsequent three-day food intake and energy expenditure in active and inactive pre-menopausal women taking oral contraceptives. Appetite, 89 (1), 183-191. TANG, Hao, DALTON, Caroline, SRISAWAT, Umarat, ZHANG, Zhi Jun and REYNOLDS, Gavin (2014). Methylation at a transcription factor-binding site on the 5-HT1A receptor gene correlates with negative symptom treatment response in first episode schizophrenia. The International Journal of Neuropsychopharmacology, 17 (04), 645-649. REYNOLDS, Gavin P., MCGOWAN, Olga O. and DALTON, Caroline F. (2014). Pharmacogenomics in psychiatry : the relevance of receptor and transporter polymorphisms. British Journal Of Clinical Pharmacology, 77 (4), 654-672.