Cole, Laura - Sheffield Hallam University - Department of Biosciences and Chemistry

个人简介

Laura was appointed to a lecturing post at Sheffield Hallam University having completed a BSc Biomedical Science and a PhD in cancer research. She is Course Leader of the BSc Biomedical Science Course and fellow of the Higher Education Academy. Her research interests include Proteomics and Mass Spectrometry Imaging to investigate tumour progression and treatment resistance mechanisms

研究领域

Laura's research has focused on the study of sinusoidal and leaky tumour vasculature, its relationship with an active tumour milieu, stress response mechanisms, vascular endothelial isoforms and the molecular switch back to viable tissue. More specifically, observing protein and lipid induction as a result of anticancer treatments, and studying the multicellular, stem cell like populations within the tumour microenvironment, possibly responsible for drug treatment resistance. She has been able to map specific changes in the molecular pathology of tumour tissue showing inverse correlations between heat shock proteins and structural proteins and those species implicated in tumour progression and metastasis. These research directions have enabled Laura to be involved in the validation of anti-cancer drug Fosbretabulin (phase II/III clinical trials) and study the proteomics and lipidomics of a range of diseased clinical tissue. As a member of the centre for mass spectrometry imaging at Sheffield Hallam University, she has disseminated her research at conferences throughout Europe, America and Canada Her research informed teaching encompasses multidisciplinary techniques along with a bioanalytical theme.

近期论文

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HARVEY, Amanda, DAY, Rebecca, COLE, Laura M., BARTLETT, Maggie, WARWICK, John, BOJAR, Richard, SMITH, David, CROSS, Neil and CLENCH, Malcolm R. (2016). MALDI-MSI for the analysis of a 3D tissue-engineered psoriatic skin model. Proteomics, 16 (11-12), 1718-1725. COLE, Laura and CLENCH, Malcolm (2015). Mass spectrometry imaging for the proteomic study of clinical tissue. PROTEOMICS - Clinical Applications, 9 (3-4), 335-341. WRIGHT, Chris, REED, Heath, PARTRIDGE, Rebecca, COLE, Laura, SELVAN, Arul and CLENCH, Malcolm (2014). Communication of multi-modal imaging: MRI, MSI, and histology. In: BCISMRM, Edinburgh, 4-5th September 2014. (Unpublished) COLE, Laura, SELVAN, Arul, WRIGHT, Chris, REED, Heath and CLENCH, Malcolm (2014). Communication of medical images to diverse audiences using multiple imaging modalities'. In: BMSS Annual Meeting 2014, Alderley Park Conference Centre, Macclesfield, Cheshire., 1st-2nd April 2014. COLE, Laura, BLUFF, Joanne E., CAROLAN, Vikki, PALEY, Martyn N., TOZER, Gillian M. and CLENCH, Malcolm (2014). MALDI-MSI and label-free LC-ESI-MS/MS shotgun proteomics to investigate protein induction in a murine fibrosarcoma model following treatment with a vascular disrupting agent. Proteomics, 14 (7-8), 890-903.