Campbell, Susan - Sheffield Hallam University - Department of Biosciences and Chemistry

个人简介

Susan was appointed to a lecturing post at SHU in 2013. Previous to this she carried out postdoctoral research at the University of Manchester. Her research interests include the regulation of protein synthesis. Her teaching interests include the development of innovative teaching methods for developing practical skills for scientists and she is the module leader for the year 1 Professional and Scientific Practice - Labs module. Susan is also the Admissions tutor for the Department of Biosciences and Chemistry and is the local ambassador for the Biochemical Society.

研究领域

My research focuses on the control of translation initiation in response to stress conditions in the budding yeast Saccharomyces cerevisiae. During translation initiation the Met-tRNAi is recruited to the 40S ribosomal subunit in a ternary complex with eIF2-GTP. On identification of an AUG codon the eIF2-GTP is hydrolysed releasing eIF2-GDP from the complex. One of the key regulatory steps in the translation initiation pathway involves the recycling of inactive GDP bound eIF2 into active GTP bound eIF2. This step is catalysed by the guanine nucleotide exchange factor eIF2B. Stresses such as nutritional starvation directly target this exchange factor by activation of a kinase, which phosphorylates the alpha subunit of the G protein eIF2. This phosphorylation inhibits the exchange activity of eIF2B thereby down-regulating translation initiation.

近期论文

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LUI, Jennifer, CASTELLI, Lydia M., PIZZINGA, Mariavittoria, SIMPSON, Clare E., HOYLE, Nathaniel P., BAILEY, Kathryn L., CAMPBELL, Susan G. and ASHE, Mark P. (2014). Granules harboring translationally active mRNAs provide a platform for P-Body formation following stress. Cell Reports, 9 (3), 944-954. CASTELLI, L M, LUI, J, CAMPBELL, Susan, ROWE, W, ZEEF, L A, HOLMES, L E, HOYLE, N P, BONE, J, SELLEY, J N, SIMS, P F and ASHE, M P (2011). Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S pre-initiation complex accumulation, while the pentose phosphate pathway is co-ordinately up-regulated. Molecular Biology Of The Cell, 22 (18), 3379-3393. SINGH, C R, WATANABE, R, ZHOU, D, JENNINGS, M D, FUKAO, A, LEE, B, IKEDA, Y, CHIORINI, J A, CAMPBELL, Susan, ASHE, M P, FUJIWARA, T, WEK, R C, PAVITT, G D and ASANO, K (2011). Mechanisms of translational regulation by a human eIF5-mimic protein. Nucleic Acids Research, 39 (19), 8314-8328. TAYLOR, E J, CAMPBELL, Susan, GRIFFITHS, C D, REID, P J, SLAVEN, J W, HARRISON, R J, SIMS, P F, PAVITT, G D, DELNERI, D and ASHE, M P (2010). Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body. Molecular Biology Of The Cell, 21 (13), 2202-2216. LUI, Jennifer, CAMPBELL, Susan and ASHE, Mark P. (2010). Inhibition of translation initiation following gucose depletion in yeast facilitates a arationalization of mRNA content. Biochemical Society Transactions, 38 (4), 1131-1136.