Bricklebank, Neil - Sheffield Hallam University - Department of Biosciences and Chemistry

个人简介

Neil was appointed to Sheffield Hallam having completed BSc Chemistry and a PhD in Inorganic Chemistry at UMIST (Manchester). He teaches inorganic and materials chemistry and has an active research group investigating the biological applications of inorganic nanomaterials. He is a Senior Fellow of the Higher Education Academy, a Chartered Chemist and a Fellow of the Royal Society of Chemistry.

研究领域

Plant Nutrients and Hydroponics Plants require a range of inorganic ions and minerals, particularly phosphate, nitrate, potassium, and other metal ions, for strong and healthy growth and development. We are working to develop new and improved nutrients for use in hydroponic systems. Hydroponics, the growth of plants in soilless media, is an advanced horticultural technique that is used commercially across the world for growing fruit and vegetable crops. We are also using mass spectrometry to study the uptake and distribution of metal ions by plants. Biomedical applications of phosphonium compounds Organo phosphonium compounds are a family of lipophilic cations that are of interest because of their potential applications in biomedical science. We have developed a series of phosphonium zwitterions and salts that can be used to prepare cationically-functionalised nanoparticles. We are investigating the interaction of the phosphonium compounds and functionalised nanoparticles as agents for mitochondria-targeted diagnostics and therapeutics. Polymer Nanocomposite materials Composite materials composed of inorganic particles and ions embedded in natural or synthetic polymers have a host of applications ranging from electro-active species and catalysts to biomedical materials. We are investigating the synthesis of materials containing halogens, especially iodine, for application as antibacterial agents and wound healing.

近期论文

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Y. Ju-Nam, Y-S. Chen, J.J.Ojeda, D.W. Allen, N.A.Cross, P.H.E.Gardiner and N. Bricklebank, 'Water-soluble gold nanoparticles stabilized with cationic phosphonium thiolate ligands' RSC Advances, 2012, 2, 10345-10351. DOI: 10.1039/C2RA21421K. ISSN: 2046-2069 CHEN, Yu-Su, ALLEN, David, CROSS, Neil A, PITAK, Mateusz B, TIZZARD, Graham J, COLES, Simon J and BRICKLEBANK, Neil (2017). Biological and structural studies of phosphonium 'masked thiolate' compounds. European Journal of Medicinal Chemistry, 125, 528-537. LALWANI, Nikhil, CHEN, Yu-Su, CROSS, Neil A., BROOKE, Gemma, ALLEN, David W., REYNOLDS, Alan, OJEDA, Jesús, TIZZARD, Graham J., COLES, Simon J. and BRICKLEBANK, Neil (2015). Triphenylarsonium-functionalised gold nanoparticles : potential nanocarriers for intracellular therapeutics. Chemical Communications, 51 (19), 4109-4111. LALWANI, Nikhil, CHEN, Yu-Su, BROOKE, Gemma, CROSS, Neil A., ALLEN, David W., REYNOLDS, Alan, OJEDA, Jesús, TIZZARD, Graham J., COLES, Simon J. and BRICKLEBANK, Neil (2015). Triphenylarsonium-functionalised gold nanoparticles: potential nanocarriers for intracellular therapeutics. Chemical Communications, 51 (19), 4109-4111. SEAMAN, Callie, FLINDERS, Bryn, EIJKEL, Gert, HEEREN, Ron M.A., BRICKLEBANK, Neil and CLENCH, Malcolm R. (2014). “Afterlife Experiment”: use of MALDI-MS and SIMS imaging for the Study of the nitrogen cycle within plants. Analytical Chemistry, 86 (20), 10071-10077.