Abell, Ben - Sheffield Hallam University - Department of Biosciences and Chemistry

个人简介

I teach and research in plant molecular biology. This is based on PhD and postdoctoral research totalling 11 years in the UK and Canada before arriving at Sheffield Hallam University. Since 2006 I have continued research as principal investigator of a research group. My research experience is applied to teaching to deliver plant biology modules that promote active learning and develop research skills.

研究领域

I lead a research group in the Biomolecular Sciences Research Centre, funded by external agencies such as the Biotechnology and Biological Sciences Research Council (BBSRC), Engineering and Physical Sciences Research Council (EPSRC), and the Biochemical Society. Our common theme is investigating how proteins and RNA are delivered to their correct destination within cells, a universal process that can result in disease when it malfunctions. To analyse protein locations we use techniques such as protein expression, cellular fractionation, and confocal fluorescence microscopy. Our work has generated publications in international science journals, and we present our work at international conferences. The research group also supports undergraduate students in their first experience of professional research, which is particularly valuable for progressing to postgraduate education. Current research projects are: • Viroid trafficking in plant cells: determining the mechanisms of RNA import into the chloroplast, which is a crucial step in the lifecycle of viroids. • Membrane proteins in translational control: characterisation of membrane-bound protein complexes associated with eIF2B, which regulates protein synthesis, and is important in neurological disease. • Tail-anchored membrane proteins: investigating the targeting and membrane insertion mechanisms, which is important due to the wide range of core cellular functions performed by these proteins

近期论文

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Kriechbaumer V, Abell BM (2012). Chloroplast envelope protein targeting fidelity is independent of cytosolic components in dual organelle assays. Front Plant Sci 3:148 DOBSON, Stephen, SUKUMAR, Arun, RIDLEY-DUFF, Rory, ROAST, Chris and ABELL, Benjamin (2015). Reciprocity and resilience: teaching and learning sustainable social enterprise through gaming. Journal of Organisational Transformation & Social Change, 12 (1), 42-56. LEONENKO, Zoya, SMITH, Rachel A. S., NABOK, Aleksey, BLAKEMAN, Ben J. F., XUE, Wei-Feng, ABELL, Benjamin and SMITH, David P. (2015). Analysis of toxic amyloid fibril interactions at natively derived membranes by ellipsometry. PLOS ONE, 10 (7), e0132309. KRIECHBAUMER, Verena, NABOK, Alexei, WIDDOWSON, Robert, SMITH, David and ABELL, Benjamin (2012). Quantification of ligand binding to g-protein coupled receptors on cell membranes by ellipsometry. PLoS ONE, 7 (9), e46221. KRIECHBAUMER, Verena, WANG, Pengwei, HAWES, Chris and ABELL, Benjamin (2012). Alternative splicing of the auxin biosynthesis gene YUCCA4 determines its subcellular compartmentation. The Plant Journal, 70 (2), 292-302. KRIECHBAUMER, Verena, NABOK, Alexei, MUSTAFA, Mohd, AL-AMMAR, Rukaiah, TSARGORODSKAYA, Anna, SMITH, David and ABELL, Benjamin (2012). Analysis of protein interactions at native chloroplast membranes by ellipsometry. PLoS ONE, 7 (3), e34455. KRIECHBAUMER, Verena, VON LOFFELHOLZ, Ottillie and ABELL, Benjamin (2012). Chaperone receptors: guiding proteins to intracellular compartments. Protoplasma, 249 (1), 21-30.