个人简介
Biosketch
I am a Reader in Nanomedicine and ERASMUS coordinator within the School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, UK. I obtained my Pharmacy degree from the same university and am a registered pharmacist. In 2004, I received my Doctor of Philosphy (Ph.D) in drug delivery from Aston University, UK, entitled Improving diagnosis and vaccination strategies against Bovine Tuberculosis. Upon completing my Ph.D I went on to undertake a Postdoctoral Research Fellow at University of New Mexico in the Advanced Drug Delivery Laboratory of Dr H Smyth, working in the area of dry powder inhalation of anticancer agents for treatment of lung cancer.
Research
My research group transgresses multiple disciplines including formulation, drug delivery, nanotechnology, polymer science, chemistry, cell and molecular biology, and have published extensively in peer-reviewed journals, conference abstracts and book chapters. The groups work is involved in the application and understanding of novel nanocarrier systems in overcoming biological barriers for the targeted delivery of small molecules and macromolecules (proteins, peptides, siRNA, miRNA) for human and veterinary use. This nanotechnology is applied in the following areas:
Lipid and polymer based nanocarriers for pulmonary delivery of vaccines.
Lipid and polymer based nanocarriers for targeted delivery of small molecules and macromolecules (proteins, peptides, siRNA, miRNA) in treatment of pulmonary diseases (lung cancer, asthma, COPD, fungal and bacterial infections).
Producing fast disintegrating tablets, thin-films and wafers for delivery of nanocarriers via oral delivery.
Smart responsive nanocarriers to biological and external factors.
Regenerative medicine.
Nanoparticle toxicology.
Extracellular vesicles as alternative delivery systems.
Degrees
1998, Liverpool John Moores University, United Kingdom, BSc (hons) 2:1, Pharmacy
近期论文
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Mohamed A, Ross K, Saleem IY, Hutcheon GA. 2016. Pulmonary Delivery of Therapeutic miR-146a Nanoparticles. AAPS National Biotechnology Conference, Boston, USA.
Mohamed A, Ross K, Saleem IY, Hutcheon GA. 2015. Polymeric Nanoparticles for the Pulmonary Delivery of miRNA to Treat Chronic Obstructive Pulmonary Disease (COPD). 42nd Annual Meeting & Exposition of the Controlled Release Society, Edinburgh.
Wagner Q, Offner D, Idoux-Gillet Y, Saleem I, Somavarapu S, Schwinte P, Benkirane-Jessel N, Keller L. 2016. Advanced nanostructured medical device combining mesenchymal cells and VEGF nanoparticles for enhanced engineered tissue vascularization NANOMEDICINE, 11 :2419-2430 >DOI >Link
Merchant Z, Buckton G, Taylor KMG, Stapleton P, Saleem IY, Zariwala MG, Somavarapu S. 2016. A New Era of Pulmonary Delivery of Nano-antimicrobial Therapeutics to Treat Chronic Pulmonary Infections CURRENT PHARMACEUTICAL DESIGN, 22 :2577-2598 >DOI >Link
Abdellatif AAH, Zayed G, El-Bakry A, Zaky A, Saleem IY, Tawfeek HM. 2016. Novel gold nanoparticles coated with somatostatin as a potential delivery system for targeting somatostatin receptors DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 42 :1782-1791 >DOI >Link
Ali HRH, Saleem IY, Tawfeek HM. 2016. Insight into inclusion complexation of indomethacin nicotinamide cocrystals JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 84 :179-188 >DOI >Link
Alfagih I, Kunda N, Alanazi F, Dennison SR, Somavarapu S, Hutcheon GA, Saleem IY. 2015. Pulmonary Delivery of Proteins Using Nanocomposite Microcarriers JOURNAL OF PHARMACEUTICAL SCIENCES, 104 :4386-4398 >DOI >Link
Kunda NK, Alfagih IM, Miyaji EN, Figueiredo DB, Goncalves VM, Ferreira DM, Dennison SR, Somavarapu S, Hutcheon GA, Saleem IY. 2015. Pulmonary dry powder vaccine of pneumococcal antigen loaded nanoparticles INTERNATIONAL JOURNAL OF PHARMACEUTICS, 495 :903-912 >DOI >Link
Kunda NK, Alfagih IM, Dennison SR, Somavarapu S, Merchant Z, Hutcheon GA, Saleem IY. 2015. Dry powder pulmonary delivery of cationic PGA-co-PDL nanoparticles with surface adsorbed model protein. Int J Pharm, 492 :213-222 >DOI >Link
Saleem IY, Diez F, Jones BE, Kayali N, Polo L. 2015. Investigation on the aerosol performance of dry powder inhalation hypromellose capsules with different lubricant levels INTERNATIONAL JOURNAL OF PHARMACEUTICS, 492 :258-263 >DOI >Link
Kunda NK, Alfagih IM, Dennison SR, Tawfeek HM, Somavarapu S, Hutcheon GA, Saleem IY. 2015. Bovine Serum Albumin Adsorbed PGA-co-PDL Nanocarriers for Vaccine Delivery via Dry Powder Inhalation PHARMACEUTICAL RESEARCH, 32 :1341-1353 >DOI >Link
Merchant Z, Taylor KMG, Stapleton P, Razak SA, Kunda N, Alfagih I, Sheikh K, Saleem IY, Somavarapu S. 2014. Engineering hydrophobically modified chitosan for enhancing the dispersion of respirable microparticles of levofloxacin EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 88 :816-829 >DOI >Link
Tawfeek HM, Saleem IY, Roberts M. 2014. Dissolution Enhancement and Formulation of Rapid-Release Lornoxicam Mini-Tablets JOURNAL OF PHARMACEUTICAL SCIENCES, 103 :2470-2483 >DOI >Link
Neelima T, Taylor KMG, Saleem I, Randle L, Elsaid Z, Somavarapu S. 2013. Amphotericin polygamma glutamic acid derivatives for the delivery of amikacin to the lung Journal of Aerosol Medicine and Pulmonary Drug Delivery, 26 :A-1-A-27 >DOI
saleem I, hutcheon G, Satyanarayana S. 2013. Pulmonary delivery of beclometasone loaded PGA-co-PDL nanocomposite microparticles Journal of Aerosol Medicine and Pulmonary Drug Delivery, 26 :A-1-A-27 >DOI
Saleem I, smyth HD. 2013. Tuning aerosol particle size distribution of metered dose inhalers using cosolvents and surfactants Duf`es . BioMed Research International, 2013 >DOI
Vadana CD, Taylor KMG, Saleem IY, Elsaid Z, Somavarapu S. 2013. SPICING UP THE LUNGS: DESIGN AND CHARACTERIZATION OF DRY POWDER FORMULATIONS OF CURCUMIN FOR LUNG DELIVERY JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 26 :A250-A250 >Link
Chavan T, Taylor KMG, Saleem IY, Randle LE, Elsaid Z, Somavarapu S. 2013. O-PALMITOYL CHITOSAN-PEG MICELLES FOR AMPHOTERICIN B DELIVERY TO THE LUNG JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 26 :A249-A250 >Link
Saleem IY, Smyth HD. 2013. Tuning aerosol particle size distribution of metered dose inhalers using cosolvents and surfactants. BioMed research international, 2013 :574310
Tawfeek HM, Evans AR, Iftikhar A, Mohammed AR, Shabir A, Somavarapu S, Hutcheon GA, Saleem IY. 2013. Dry powder inhalation of macromolecules using novel PEG-co-polyester microparticle carriers. Int J Pharm, 441 :611-619 >DOI >Link
Kunda NK, Somavarapu S, Gordon SB, Hutcheon GA, Saleem IY. 2013. Nanocarriers targeting dendritic cells for pulmonary vaccine delivery. Pharm Res, 30 :325-341 >DOI >Link
Khan S, Batchelor H, Hanson P, Saleem IY, Perrie Y, Mohammed AR. 2013. Dissolution rate enhancement, in vitro evaluation and investigation of drug release kinetics of chloramphenicol and sulphamethoxazole solid dispersions. Drug Dev Ind Pharm, 39 :704-715 >DOI >Link
Tawfeek H, Khidr SH, Samy EM, Ahmed SM, Hutcheon G, Saleem I. 2011. Effect of PEGylation on spray dried PGA-co-PDL pulmonary carrier microparticles Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24 :303-334
Al-Fagih IM, Alanazi FK, Hutcheon GA, Saleem IY. 2011. Recent Advances Using Supercritical Fluid Techniques for Pulmonary Administration of Macromolecules via Dry Powder Formulations Drug Delivery Letters, 1 :128-134
Tawfeek H, Khidr S, Samy E, Ahmed S, Murphy M, Mohammed A, Shabir A, Hutcheon G, Saleem I. 2011. Poly(Glycerol Adipate-co-ω-Pentadecalactone) Spray-Dried Microparticles as Sustained Release Carriers for Pulmonary Delivery Pharmaceutical Research, 28 :2086-2097 >Link
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