Ross, Kehinde - Liverpool John Moores University - School of Pharmacy and Biomolecular Sciences

个人简介

My current research focuses on the role of microRNAs and associated pathways in skin disorders such as psoriasis, eczema, impaired wound healing and alopecia. I also have an interdisciplinary collaboration on the development of lipid and polymer nanocarriers for miRNA-directed therapy for inflammatory diseases. I joined LJMU as a lecturer in August 2008. Prior to that I completed postdoctoral research in the Dermatological Sciences laboratory at Newcastle University under the guidance of Professor Nick Reynolds. For my PhD at the University of Sheffield, I studied cytokine signalling proteins associated with inflammatory diseases, under the supervision of Dr François Guesdon and Professor Steve Dower. A year was spent at GSK Stevenage under the supervision of Dr Filippo Volpe. Research in my laboratory is supported by the British Skin Foundation, the Cicatricial Alopecia Research Foundation, the Royal Liverpool and Broadgreen Hospitals NHS Trust and the Ministry of Health, Oman. I have supervised 4 postdoctoral/visiting scientists. I am a member of the Biochemical Society, the British Society for Investigative Dermatology, the Physiological Society and the European Tissue Repair Society. I am also an affiliate member of the Royal Society of Chemistry. My teaching activities focus on signal transduction by receptor tyrosine kinases, G protein-coupled receptors and cytokine receptors. Key themes include MAP kinase cascades, PI3K signalling, store-operated calcium entry and NF-kB activation. I have supervised over 30 undergraduate project students. A Fellow of the Higher Education Academy (FHEA), I was nominated for the Liverpool Students' Union Amazing Teacher Award in 2011, 2013, 2015 and 2016. Degrees 2013, Liverpool John Moores University, United Kingdom, Postgraduate Certificate for Learning and Teaching in Higher Education 2001, University of Sheffield, United Kingdom, PhD 1997, Brunel University, United Kingdom, BSc (Honours)

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Roberts JC, Warren RB, Griffiths CEM, Ross K. 2013. Expression of microRNA-184 in keratinocytes represses argonaute 2. Journal of Cellular Physiology, 228 :2314-2323 >DOI Jans, R , Mottram, L , Johnson, DL , Brown, AM , Sikkink, S , Ross,K , Reynolds, NJ . 2012. Lysophosphatidic Acid Promotes Cell Migration through STIM1- and Orai1-Mediated Ca2+i Mobilization and NFAT2 Activation. Journal of Investigative Dermatology, 133 :793-802 >DOI Ross K, Whitaker M, Reynolds NJ. 2007. Agonist-induced Calcium Entry correlates with STIM1 translocation. Journal of Cellular Physiology, 211 :569-576 >DOI Ross K, Yang L, Dower S, Volpe F, Guesdon F. 2002. Identification of Threonine 66 as a Functionally Critical Residue of the Interleukin-1 Receptor-associated Kinase (IRAK). Journal of Biological Chemistry, 277 :37414-37421 Richardson A, Sexton D, Powell AK, Ross K. 2016. Argonaute Expression in Psoriasis and Epidermal Keratinocytes. Inflammatory diseases - mechanisms and clinical perspectives, Maynooth University, Ireland. A Biochemical Society Focused Meeting. Mohamed A, Ross K, Saleem IY, Hutcheon GA. 2016. Pulmonary Delivery of Therapeutic miR-146a Nanoparticles. AAPS National Biotechnology Conference, Boston, USA. Mohamed A, Ross K, Saleem IY, Hutcheon GA. 2015. Polymeric Nanoparticles for the Pulmonary Delivery of miRNA to Treat Chronic Obstructive Pulmonary Disease (COPD). 42nd Annual Meeting & Exposition of the Controlled Release Society, Edinburgh. Coyne V, Ross K, Shriver Z, Wills B, Powell AK. 2012. Applying an HPLC structural glycomics strategy to investigate triggers of changes in HS structure. Biochemical Society/Royal Society of Chemistry workshop. London. Tusubira D, Wabinga H, Ross K, Masembe C. 2012. The Potential of Serum micro-RNAs in the Screening and early detection of Breast Cancer. Advanced Summer School on Nutrition and Disease: Biochemical and Molecular Insights. South Africa. Farrer DJ, Roberts JC, Ross K. 2016. MicroRNA-9 represses sirtuin 1 (SIRT1) in human keratinocytes. Scholars Bulletin, 2 :525-529 >DOI Roberts JC, Warren RB, Griffiths CEM, Ross K. 2013. Expression of microRNA-184 in keratinocytes represses argonaute 2. Journal of Cellular Physiology, 228 :2314-2323 >DOI Jans, R , Mottram, L , Johnson, DL , Brown, AM , Sikkink, S , Ross,K , Reynolds, NJ . 2012. Lysophosphatidic Acid Promotes Cell Migration through STIM1- and Orai1-Mediated Ca2+i Mobilization and NFAT2 Activation. Journal of Investigative Dermatology, 133 :793-802 >DOI Fearon P, Lonsdale-Eccles AA, Ross OK, Todd C, Sinha A, Allain F, Reynolds NJ. 2011. Keratinocyte Secretion of Cyclophilin B via the Constitutive Pathway Is Regulated through Its Cyclosporin-Binding Site. Journal of Investigative Dermatology, 131 :1085-1094 >DOI Ross K, Parker G, Whitaker M, Reynolds NJ. 2008. Inhibition of calcium-independent phospholipase A impairs agonist-induced calcium entry in keratinocytes. British Journal of Dermatology, 158 :31-37 >DOI Hampton P, Ross OK, Reynolds NJ. 2007. Increased nuclear beta-catenin in suprabasal involved psoriatic epidermis British Journal of Dermatology, 157 :1168-1177 >DOI Ross K, Whitaker M, Reynolds NJ. 2007. Agonist-induced Calcium Entry correlates with STIM1 translocation. Journal of Cellular Physiology, 211 :569-576 >DOI Hoogduijn MJ, Cemeli E, Ross K, Anderson, D , Thody AJ, Wood JM. 2004. Melanin Protects Melanocytes and Keratinocytes Against H2O2-induced DNA Strand Breaks Through its Ability to Bind Ca2+. Experimental Cell Research, 294 :60-67 >DOI Yang L, Ross K, Qwarnstrom EE. 2003. RelA Control Of IkBa Phosphorylation: A Positive Feedback Loop For High Affinity NF-kB Complexes. Journal of Biological Chemistry, 278 :30881-30888 >DOI Ross K, Yang L, Dower S, Volpe F, Guesdon F. 2002. Identification of Threonine 66 as a Functionally Critical Residue of the Interleukin-1 Receptor-associated Kinase (IRAK). Journal of Biological Chemistry, 277 :37414-37421 Ross K, Richardson A, Tan TH, Roberts JC. 2016. Argonautes and the human keratinocyte: the microRNA connection BRITISH JOURNAL OF DERMATOLOGY, 20th Anniversary Conference of the British-Skin-Foundation on Skin Deep - 20 Years of Research 175 :61-61 >Link Tan TH, Yesudian, PD, West, L, Al-Sharqi, A, Parslew R, Ross K. 2016. Evaluation of the relationship between aquaporin-9 and microRNA-205 expression in psoriatic epidermis. British Journal of Dermatology, British Association of Dermatologists 96th Annual Meeting 175 :52-52 >DOI Jans R, Mottram L, Johnson J, Brown AM, Sikkink S, Ross K, Reynolds NJ. 2012. Lysophosphatidic acid promotes keratinocyte migration through STIM1-regulated Orai1-Ca2+ channels and NFAT2 activation. Journal of Investigative Dermatology, 42nd Annual Meeting of the European Society for Dermatological Research (ESDR) 132 :S101-S101 Fearon P, Lonsdale-Eccles AA, Ross K, Todd C, Allain A, Reynolds NJ. 2009. Secretion of chemotactic cyclophilin B by keratinocytes is regulated through its cyclosporin binding site. Journal of Investigative Dermatology, 37th Annual Meeting of the European Society for Dermatological Research (ESDR 2007) 127 :S39-S39 Milner S, Ross K, Reynolds NJ. 2009. Inhibition of store-operated calcium entry and STIM1 translocation by dithranol is dependent upon superoxide formation. British Journal of Dermatology, Annual Meeting of the British Society for Investigative Dermatology 160 :914-914 Jans R, Brown AM, Ross K, Reynolds NJ. 2009. Lysophosphatidic acid-evoked calcium fluxes promote keratinocyte migration through Orai1, lipid rafts and NFAT. Journal of Investigative Dermatology, 69th Annual Meeting of the Society of Investigative Dermatology 129 :S90-S90