Powell, Andrew - Liverpool John Moores University - School of Pharmacy and Biomolecular Sciences

个人简介

EXPERIENCE - Twenty years research experience in carbohydrate/protein biochemistry, molecular interactions, assay development, macromolecule purification/analysis, cell signalling and microbial adhesion. - First-hand experience of commercial science, including intellectual property exploitation and contract research as cofounder/director of university spin-out drug discovery company: IntelliHep Ltd. - Member of UK Glycoarrays Consortium, IBCarb Network in Industrial Biotechnology and Biochemical Society Local Ambassador. - Supervised ~ 50 honours project students and ~10 masters/PhD students. - Lecturing of protein and carbohydrate structure, purification, analysis and interactions at undergraduate and masters level with a focus on technical approaches (numerous nominations/shortlistings for university teaching, personal tutor, project supervisor and employability awards). EMPLOYMENT 08 – to date. Senior Lecturer in Biochemistry, Liverpool John Moores University, UK. 08 – to date. Honarary Fellow, University of Liverpool, UK. 02 – to date. CoFounder & Director, IntelliHep Ltd, UK. 07 – 08. Postdoctoral Research Fellow (EPSRC), University of Liverpool, UK. 04 – 07. Postdoctoral Research Fellow (BBSRC), University of Liverpool, UK. 01 – 03. Postdoctoral Research Fellow (BBSRC), University of Birmingham, UK. 97 – 01. PhD student (MRC), University of Birmingham, UK. 96 – 97. Postgraduate Research Assistant, University of Oxford, UK. Degrees 2012, Liverpool John Moores University, United Kingdom, Postgraduate Certificate for Learning and Teaching in Higher Education (High distinction) 2001, University of Birmingham, United Kingdom, PhD (Biochemistry) 1996, University of Oxford, United Kingdom, MBiochem with honours (Biochemistry)

研究领域

- Proteins (e.g. growth factors, cytokines, chemokines, proteases) - Carbohydrates (e.g. heparin/heparan sulfate/glycosaminoglycans) - Method Development (Immunoassays, arrays, biosensors, bioassays, chromatography). - Analytical Biochemistry (molecular interactions, structure-function relationships, macromolecule purification & analysis). - Cell Biology (cell signaling, microbial adhesion, homeostasis & immunity of epithelia, blood coagulation). - Pharmaceuticals (pharmaceutical detection, biopharmaceutical development and characterisation).

近期论文

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Ahmed YA, Yates EA, Moss DJ, Loeven MA, Hussain S-A, Hohenester E, Turnbull JE, Powell AK. 2016. Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity MOLECULAR BIOSYSTEMS, 12 :3166-3175 >DOI >Link Lima M, Cavalheiro RP, Viana G, Meneghetti M, Rudd TR, Skidmore MA, Powell AK, Yates EA. 2016. 19F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy. Glycoconjugate Journal, >DOI Powell AK, Ahmed YA, Yates EA, Turnbull JE. 2010. Generating heparan sulfate saccharide libraries for glycomics applications. Nat Protoc, 5 :821-833 >DOI >Link Powell AK, Zhi Z-L, Turnbull JE. 2009. Saccharide microarrays for high-throughput interrogation of glycan-protein binding interactions. Methods Mol Biol, 534 :313-329 >DOI >Link Tissot B, Gasiunas N, Powell AK, Ahmed Y, Zhi Z-L, Haslam SM, Morris HR, Turnbull JE, Gallagher JT, Dell A. 2007. Towards GAG glycomics: analysis of highly sulfated heparins by MALDI-TOF mass spectrometry. Glycobiology, 17 :972-982 >DOI >Link Powell AK, Yates EA, Fernig DG, Turnbull JE. 2004. Interactions of heparin/heparan sulfate with proteins: appraisal of structural factors and experimental approaches. Glycobiology, 14 :17R-30R >DOI >Link Westblade LF, Ilag LL, Powell AK, Kolb A, Robinson CV, Busby SJW. 2004. Studies of the Escherichia coli Rsd-sigma70 complex. J Mol Biol, 335 :685-692 >Link Powell AK, Fernig DG, Turnbull JE. 2002. Fibroblast growth factor receptors 1 and 2 interact differently with heparin/heparan sulfate. Implications for dynamic assembly of a ternary signaling complex. J Biol Chem, 277 :28554-28563 >DOI >Link Richardson A, Sexton D, Powell AK, Ross K. 2016. Argonaute Expression in Psoriasis and Epidermal Keratinocytes. Inflammatory diseases - mechanisms and clinical perspectives, Maynooth University, Ireland. A Biochemical Society Focused Meeting. Ahmed YA, Loeven MA, Hussain S, Yates EA, Moss DJ, Hohenester E, Turnbull JE, Powell AK. 2014. Selective effects of chemically modified heparins on Slit & Robo complex formation and biological activity 27th International Carbohydrate Symposium (ICS27), Bangalore, India. Ahmed YA, Yates EA, Hohenester E, Powell AK, Turnbull JE. 2014. Selective effects of chemically modified heparins and heparan sulfate oligosaccharides on Slit & Robo complex formation and biological activity. Proteoglycans, Gordon Research Conference, Proctor Academy, Andover, NH, USA Ahmed YA, Atrih AM, Guimond SE, Powell AK, Turnbull JE. 2012. Sequence-specific HS modulation of FGF signalling revealed by an ES-MS sequencing strategy Gordon Research Conference on Fibroblast Growth Factors in Development & Disease, Les Diablerets, Switzerland Coyne V, Ross K, Shriver Z, Wills B, Powell AK. 2012. Applying an HPLC structural glycomics strategy to investigate triggers of changes in HS structure Carbohydrate analysis and glycomics: where next? Biochemical Society/Royal Society of Chemistry workshop Ahmed YA, Powell AK, Yates EA, Moss D, Hohenester E, Turnbull JE. 2010. Involvement of Heparan Sulfate in Slit-Robo interactions: Evidence that Specific Sulfate Groups are Essential Structural Glycobiology and human health, Royal Holloway, University of London, UK Powell A, Zhi Z-L , Ahmed Y, Karamanska R, Fais M, Otto DME, Crocker RP, Yates EA, Field RA, Turnbull JE. 2010. Heparan sulfate saccharide arrays – platform development, library screening and data interpretation. Structural glycobiology and human health, Biochemical Society conference Ahmed YA, Powell AK, Yates EA, Moss D, Hohenester E, Turnbull JE. 2009. Involvement of Heparan Sulfate in Slit-Robo interactions: Evidence that Specific Sulfate Groups are Essential The 67th Harden conference: Decoding the biology of heparan sulfate proteoglycans, Robinson College, Cambridge, UK Powell A, Zhi Z-L, Ahmed Y, Karamanska R, Fais M, Otto DME, Rudd TR, Blackburn JM, Russell DA, Crocker PR. 2009. Development and evaluation of heparan sulfate glycoarrays for protein interaction screening 67th Harden conference (Biochemical Society) - Decoding the biology of heparan sulfate proteoglycans, Robinson College, Cambridge, Ahmed YA, Powell AK, Guimond S, Atrih A, Turnbull JE. 2007. Investigating the specificity of heparin/ heparan sulfate activity and protein interactions using saccharide libraries FEBS Advanced Lecture Course, Matrix Pathobiology, Signaling and Molecular Targets. Patras, Greece Powell AK, Ahmed Y, Zhi Z-L, Rudd TR, Nichols R, Fernig DG, Yates EA, Turnbull JE. 2007. Saccharide microarrays for the investigation of heparan-sulfate protein interactions 14th European carbohydrate symposium Ahmed YA, Yates EA, Moss DJ, Loeven MA, Hussain S-A, Hohenester E, Turnbull JE, Powell AK. 2016. Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity MOLECULAR BIOSYSTEMS, 12 :3166-3175 >DOI >Link Lima M, Cavalheiro RP, Viana G, Meneghetti M, Rudd TR, Skidmore MA, Powell AK, Yates EA. 2016. 19F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy. Glycoconjugate Journal, >DOI Meneghetti MCZ, Hughes AJ, Rudd TR, Nader HB, Powell AK, Yates EA, Lima MA. 2015. Heparan sulfate and heparin interactions with proteins JOURNAL OF THE ROYAL SOCIETY INTERFACE, 12 >DOI >Link Solari V, Rudd TR, Guimond SE, Powell AK, Turnbull JE, Yates EA. 2015. Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding. Organic and Biomolecular Chemistry, 13 :6066-6072 >DOI Puvirajesinghe TM, Ahmed YA, Powell AK, Fernig DG, Guimond SE, Turnbull JE. 2012. Array-based Functional Screening of Heparin Glycans. Chemistry & Biology, 19 :553-558 Otto DME, Campanero-Rhodes MA, Karamanska R, Powell AK, Bovin N, Turnbull JE, Field RA, Blackburn J, Feizi T, Crocker PR. 2011. An expression system for screening of proteins for glycan and protein interactions. Anal Biochem, 411 :261-270 >DOI >Link