Madden, Judith - Liverpool John Moores University - School of Pharmacy and Biomolecular Sciences

个人简介

Judith Madden obtained a dual honours degree in chemistry and pharmacology from the University of Sheffield before completing a PhD in computer-aided drug development at Liverpool John Moores University. She worked as post-doctoral research associate at the University of Manchester investigating pharmacokinetics of drugs and other compounds of interest. Her research interests have developed from the combination this earlier work. Currently her work is focussed on the in silico prediction of activity/toxicity and ADME properties of drugs, cosmetics and other chemicals. Degrees 1995, Liverpool John Moores University, United Kingdom, Ph D 1991, University of Sheffield, United Kingdom, BSc (Dual Hons) Chemistry and Pharmacology

近期论文

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Ebbrell DJ, Madden JC, Cronin MTD, Schultz TW, Enoch SJ. 2016. Development of a Fragment-Based in Silico Profiler for Michael Addition Thiol Reactivity CHEMICAL RESEARCH IN TOXICOLOGY, 29 :1073-1081 >DOI >Link Ellison CM, Piechota P, Madden JC, Enoch SJ, Cronin MTD. 2016. Adverse Outcome Pathway (AOP) Informed Modeling of Aquatic Toxicology: QSARs, Read-Across, and Interspecies Verification of Modes of Action ENVIRONMENTAL SCIENCE & TECHNOLOGY, 50 :3995-4007 >DOI >Link Ates G, Steinmetz FP, Doktorova TY, Madden JC, Rogiers V. 2016. Linking existing in vitro dermal absorption data to physicochemical properties: Contribution to the design of a weight-of-evidence approach for the safety evaluation of cosmetic ingredients with low dermal bioavailability REGULATORY TOXICOLOGY AND PHARMACOLOGY, 76 :74-78 >DOI >Link Richarz A-N, Madden JC, Marchese Robinson RL, Lubiński Ł, Mokshina E, Urbaszek P, Kuz׳min VE, Puzyn T, Cronin MTD. 2015. Development of computational models for the prediction of the toxicity of nanomaterials Perspectives in Science, 3 :27-29 >DOI Nelms MD, Mellor CL, Cronin MTD, Madden JC, Enoch SJ. 2015. Development of an in Silico Profiler for Mitochondrial Toxicity CHEMICAL RESEARCH IN TOXICOLOGY, 28 :1891-1902 >DOI >Link Nelms MD, Ates G, Madden JC, Vinken M, Cronin MTD, Rogiers V, Enoch SJ. 2015. Proposal of an in silico profiler for categorisation of repeat dose toxicity data of hair dyes Archives of Toxicology, 89 :733-741 >DOI Hewitt M, Ellison CM, Cronin MTD, Pastor M, Steger-Hartmann T, Munoz-Muriendas J, Pognan F, Madden JC. 2015. Ensuring confidence in predictions: A scheme to assess the scientific validity of in silico models ADVANCED DRUG DELIVERY REVIEWS, 86 :101-111 >DOI >Link Steinmetz FP, Madden JC, Cronin MTD. 2015. Data Quality in the Human and Environmental Health Sciences: Using Statistical Confidence Scoring to Improve QSAR/QSPR Modeling JOURNAL OF CHEMICAL INFORMATION AND MODELING, 55 :1739-1746 >DOI >Link Ellison CM, Madden JC, Cronin MTD, Enoch SJ. 2015. Investigation of the Verhaar scheme for predicting acute aquatic toxicity: improving predictions obtained from Toxtree ver. 2.6. Chemosphere, 139 :146-154 >DOI >Link Wen Y, Su L, Qin W, Zhao Y, Madden JC, Steinmetz FP, Cronin MTD. 2015. Investigation of Critical Body Residues and Modes of Toxic Action Based on Injection and Aquatic Exposure in Fish WATER AIR AND SOIL POLLUTION, 226 >DOI >Link Enoch SJ, Roberts DW, Madden JC, Cronin MTD. 2014. Development of an In Silico Profiler for Respiratory Sensitisation ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 42 :367-375 >Link Hutchinson TH, Madden JC, Naidoo V, Walker CH. 2014. Comparative metabolism as a key driver of wildlife species sensitivity to human and veterinary pharmaceuticals PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 369 >DOI >Link Madden JC, Rogiers V, Vinken M. 2014. Application of in silico and in vitro methods in the development of adverse outcome pathway constructs in wildlife PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 369 >DOI >Link Rodriguez-Sanchez N, Cronin MTD, Lillicrap A, Madden JC, Piechota P, Tollefsen KE. 2014. DEVELOPMENT OF A LIST OF REFERENCE CHEMICALS FOR EVALUATING ALTERNATIVE METHODS TO IN VIVO FISH BIOACCUMULATION TESTS ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 33 :2740-2752 >DOI >Link Steinmetz FP, Enoch SJ, Madden JC, Nelms MD, Rodriguez-Sanchez N, Rowe PH, Wen Y, Cronin MTD. 2014. Methods for assigning confidence to toxicity data with multiple values Identifying experimental outliers SCIENCE OF THE TOTAL ENVIRONMENT, 482 :358-365 >DOI >Link Lubinski L, Urbaszek P, Gajewicz A, Cronin MTD, Enoch SJ, Madden JC, Leszczynska D, Leszczynski J, Puzyn T. 2013. Evaluation criteria for the quality of published experimental data on nanomaterials and their usefulness for QSAR modelling SAR and QSAR in Environmental Research, 24 :995-1008 >DOI Lubinski L, Urbaszek P, Gajewicz A, Cronin MTD, Enoch S, Madden JC, Leszczynska D, Leszczynski J, Puzyn T. 2013. Evaluation criteria for the quality of published experimental data on nanomaterials and their usefulness for QSAR modelling SAR and QSAR in Environmental Research, 24 :995-1008 >DOI Piechota P, Cronin MTD, Hewitt M, Madden JC. 2013. Pragmatic approaches to using computational methods to predict xenobiotic metabolism. J Chem Inf Model, 53 :1282-1293 >DOI >Link Ledbetter MR, Gutsell S, Hodges G, O'Connor S, Madden JC, Rowe PH, Cronin MTD. 2013. Prediction of immobilised artificial membrane chromatography retention factors using theoretical molecular fragments and structural features. SAR QSAR Environ Res, 24 :661-678 >DOI >Link Yang L, Neagu D, Cronin MTD, Hewitt M, Enoch SJ, Madden JC, Przybylak K. 2013. Towards a fuzzy expert system on toxicological data quality assessment Molecular Informatics, 32 :65-78 >DOI Ledbetter MR, Gutsell S, Hodges G, Madden JC, Rowe PH, Cronin MTD. 2012. Robustness of an immobilized artificial membrane high-performance liquid chromatography method for the determination of lipophilicity Journal of Chemical and Engineering Data, 57 :3696-3700 >DOI Madden JC, Hewitt M, Przybylak K, Vandebriel RJ, Piersma AH, Cronin MTD. 2012. Strategies for the optimisation of in vivo experiments in accordance with the 3Rs philosophy. Regul Toxicol Pharmacol, 63 :140-154 >DOI >Link Przybylak KR, Madden JC, Cronin MTD, Hewitt M. 2012. Assessing toxicological data quality: basic principles, existing schemes and current limitations. SAR QSAR Environ Res, 23 :435-459 >DOI >Link Schwöbel JAH, Madden JC, Cronin MTD. 2011. Application of a chemical reactivity database to predict toxicity for reactive mechanisms Journal of Cheminformatics, 3 >DOI Ledbetter MR, Gutsell S, Hodges G, Madden JC, O'Connor S, Cronin MTD. 2011. Database of published retention factors for immobilized artificial membrane HPLC and an assessment of the effect of experimental variability. Environ Toxicol Chem, 30 :2701-2708 >DOI >Link