Powner, Matthew - University College London

个人简介

Education Other Postgraduate qualification (including professional), ATQ01 - Successfully completed an institutional provision in teaching in the HE sector | Other Postgraduate qualification (including professional), ATQ02 - Recognised by the HEA as an Associate Fellow | University of Manchester Doctorate, Doctor of Philosophy 2009 University of Manchester Other higher degree, Master of Chemistry (Honours) 2005 Biography I was born in Wensleydale, North Yorkshire, UK, in 1981. I obtained a first-class master’s degree in chemistry at the University of Manchester (2005), where I was awarded the Royal Society of Chemistry prize, the Degussa award, the Sigma-Aldrich prize, the Glaxo prize, the Eric Braithwaite prize, the Swan prize and the Merck Sharp & Dohme award. I then completed a medicinal chemistry internship at AstraZeneca, Alderley Park, before returning to Manchester to complete my Ph.D. (2009) and a short EPSRC Doctoral Prize postdoctoral fellowship with John Sutherland FRS. In 2009 I was awarded a Harvard Research Fellowship to work with Nobel laureate Jack Szostak FRS at Massachusetts General Hospital, Boston, USA. I returned to the U.K. in 2011, joining UCL as a lecturer in the chemistry department, where I am currently Professor of Organic Chemistry and an Investigator of the Simons Foundation Collaboration on the Origins of Life. I have been awarded various prizes and fellowships in recognition of my research, including the ISSOL Stanley Miller Award (2011), the SET for Britain Roscoe Medal (2012), first prize in the Origins of Life Challenge (2012; jointly with John Sutherland FRS), an EPSRC Early Career Fellowship (2013), a Bürgenstock JPS Fellowship (2015), the Thieme Chemistry Journal Award (2015), a Center for Advanced Studies Fellowship (2016) and the RSC Harrison-Meldola Memorial Prize (2019).

研究领域

My research interests center around chemistry associated with the origin of life and, along with my research group, I have made contributions in the areas of nucleic acid and amino acid chemistry, protometabolic networks, ribozymes, lipids, crystal engineering, green chemistry, catalysis and photochemistry. Our experiments are directed toward understanding the emergence of the nucleic acids, peptides, lipids and core components of the central metabolism used by life. Overlaid on this, we investigate the mechanisms by which information transfer, catalysis and self-assembly can emerge in networks of these molecules.

近期论文

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Prebiotic synthesis of cysteine peptides that catalyze peptide ligation in neutral water Journal article; 2020; Science Heated gas bubbles enrich, crystallize, dry, phosphorylate and encapsulate prebiotic molecules Journal article; 2019; Springer Science and Business Media LLC Peptide ligation by chemoselective aminonitrile coupling in water Journal article; 2019; Nature Publishing Group Selective prebiotic conversion of pyrimidine and purine anhydronucleosides into Watson-Crick base-pairing arabino-furanosyl nucleosides in water Journal article; 2018; Nature Publishing Group Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides Journal article; 2017; Nature Publishing Group Prebiotic selection and assembly of proteinogenic amino acids and natural nucleotides from complex mixtures Journal article; 2017; Nature Publishing Group Prebiotic synthesis of phosphoenol pyruvate by α-phosphorylation-controlled triose glycolysis Journal article; 2016; Nature Publishing Group Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions Journal article; 2009; NATURE Analyses of Aliphatic Aldehydes and Ketones in Carbonaceous Chondrites Journal article; 2019; ACS Publications Prebiotic nucleic acids need space to grow Journal article; 2018; Nature Publishing Group Protocells realize their potential Journal article; 2018; Nature Catalysis Scalable synthesis of 2,2'-anhydro-arabinofuranosyl imidazoles Journal article; 2017; Georg Thieme Verlag Selective Acylation of Nucleosides, Nucleotides, and Glycerol-3- phosphocholine in Water Journal article; 2016; Georg Thieme Verlag One-step protecting-group-free synthesis of azepinomycin in water Journal article; 2015; Royal Society of Chemistry Multicomponent assembly of proposed DNA precursors in water.Journal article; 2012; J Am Chem Soc Chemoselective Multicomponent One-Pot Assembly of Purine Precursors in Water (vol 132, pg 16677, 2010)Journal article; 2011; JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Erratum: Chemoselective multicomponent one-pot assembly of purine precursors in water (Journal of the American Chemical Society (2010) 132 (16677-16688) DOI:10.1021/ja108197s)Journal article; 2011; Journal of the American Chemical Society