近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Gonzalez JA, Ogba OM, Morehouse GF, Rosson N, Houk KN, Leach AG, Cheong PH-Y, Burke MD, Lloyd-Jones GC. 2016. MIDA boronates are hydrolysed fast and slow by two different mechanisms NATURE CHEMISTRY, 8 :1067-1075 >DOI >Link Cox PA, Leach AG, Campbell AD, Lloyd-Jones GC. 2016. Protodeboronation of Heteroaromatic, Vinyl, and Cyclopropyl Boronic Acids: pH-Rate Profiles, Autocatalysis, and Disproportionation JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138 :9145-9157 >DOI >Link Cumming JG, MacFaul PA, Leach AG. 2015. Novel N-thiazolyl piperazine-1-carboxamide CCR2 antagonists-investigation of an unexpected reaction with glutathione MedChemComm, 6 :2140-2145 >DOI Barker C, Lukac I, Leach AG. 2015. Designing Hydroxamates and Reversed Hydroxamates to Inhibit Zinc-containing Proteases but not Cytochrome P450s: Insights from Quantum Mechanics and Protein-ligand Crystal Structures Molecular Informatics, 34 :608-614 >DOI Barker C, Lukac I, Leach AG. 2015. Designing Hydroxamates and Reversed Hydroxamates to Inhibit Zinc-containing Proteases but not Cytochrome P450s: Insights from Quantum Mechanics and Protein-ligand Crystal Structures MOLECULAR INFORMATICS, 34 :608-614 >DOI >Link Noonan G, Leach AG. 2015. A mechanistic proposal for the protodeboronation of neat boronic acids: boronic acid mediated reaction in the solid state ORGANIC & BIOMOLECULAR CHEMISTRY, 13 :2555-2560 >DOI >Link Leach AG, Kidley NJ. 2014. Cytochrome P450 Substrate Recognition and Binding :103-132 >DOI Leach AG. 2014. Tactics to avoid inhibition of cytochrome P450s Topics in Medicinal Chemistry, 9 :107-158 >DOI Scott JS, Bowker SS, Brocklehurst KJ, Brown HS, Clarke DS, Easter A, Ertan A, Goldberg K, Hudson JA, Kavanagh S, Laber D, Leach AG, Macfaul PA, Martin EA, McKerrecher D, Schofield P, Svensson PH, Teague J. 2014. Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists Journal of Medicinal Chemistry, 57 :8984-8998 >DOI Leach AG. 2014. Predicting the activity and toxicity of new psychoactive substances: a pharmaceutical industry perspective. Drug Test Anal, 6 :739-745 >DOI >Link Plowright AT, Barton P, Bennett S, Birch AM, Birtles S, Buckett LK, Butlin RJ, Davies RDM, Ertan A, Gutierrez PM, Kemmitt PD, Leach AG, Svensson PH, Turnbull AV, Waring MJ. 2013. Design and synthesis of a novel series of cyclohexyloxy-pyridyl derivatives as inhibitors of diacylglycerol acyl transferase 1 MedChemComm, 4 :151-158 >DOI Scott JS, Berry DJ, Brown HS, Buckett L, Clarke DS, Goldberg K, Hudson JA, Leach AG, Macfaul PA, Raubo P, Robb G. 2013. Achieving improved permeability by hydrogen bond donor modulation in a series of MGAT2 inhibitors MedChemComm, 4 :1305-1311 >DOI Leach AG, McCoull W, Bailey A, Barton P, Mee C, Rosevere E. 2013. Experimental testing of quantum mechanical predictions of mutagenicity: aminopyrazoles. Chem Res Toxicol, 26 :703-709 >DOI >Link Dossetter AG, Griffen EJ, Leach AG. 2013. Matched molecular pair analysis in drug discovery. Drug Discov Today, 18 :724-731 >DOI >Link Addie M, Ballard P, Buttar D, Crafter C, Currie G, Davies BR, Debreczeni J, Dry H, Dudley P, Greenwood R, Johnson PD, Kettle JG, Lane C, Lamont G, Leach A, Luke RWA, Morris J, Ogilvie D, Page K, Pass M, Pearson S, Ruston L. 2013. Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases. J Med Chem, 56 :2059-2073 >DOI >Link Waring MJ, Birch AM, Birtles S, Buckett LK, Butlin RJ, Campbell L, Gutierrez PM, Kemmitt PD, Leach AG, MacFaul PA, O'Donnell C, Turnbull AV. 2013. Optimisation of biphenyl acetic acid inhibitors of diacylglycerol acetyl transferase 1 - The discovery of AZD2353 MedChemComm, 4 :159-164 >DOI Leach AG, Olsson LL, Warner DJ. 2013. A monomeric form of iNOS can rationalise observed SAR for inhibitors of dimerisation: Quantum mechanics and docking compared MedChemComm, 4 :180-186 >DOI Scott JS, Birch AM, Brocklehurst KJ, Brown HS, Goldberg K, Groombridge SD, Hudson JA, Leach AG, MacFaul PA, McKerrecher D, Poultney R, Schofield P, Svensson PH. 2013. Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonists MedChemComm, 4 :95-100 >DOI Goldberg FW, Birch AM, Leach AG, Groombridge SD, Snelson WL, Gutierrez PM, Hammond CD, Birtles S, Buckett LK. 2013. Discovery and optimization of efficacious neutral 4-amino-6-biphenyl-7,8- dihydropyrimido[5,4-f][1,4]oxazepin-5-one diacylglycerol acyl transferase-1 (DGAT1) inhibitors MedChemComm, 4 :165-174 >DOI Goldberg FW, Leach AG, Scott JS, Snelson WL, Groombridge SD, Donald CS, Bennett SNL, Bodin C, Gutierrez PM, Gyte AC. 2012. Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. J Med Chem, 55 :10652-10661 >DOI >Link Cosgrove DA, Green KM, Leach AG, Poirrette A, Winter J. 2012. A system for encoding and searching Markush structures. J Chem Inf Model, 52 :1936-1947 >DOI >Link Norman RA, Schott A-K, Andrews DM, Breed J, Foote KM, Garner AP, Ogg D, Orme JP, Pink JH, Roberts K, Rudge DA, Thomas AP, Leach AG. 2012. Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase. J Med Chem, 55 :5003-5012 >DOI >Link McCoull W, Addie MS, Birch AM, Birtles S, Buckett LK, Butlin RJ, Bowker SS, Boyd S, Chapman S, Davies RDM, Donald CS, Green CP, Jenner C, Kemmitt PD, Leach AG, Moody GC, Gutierrez PM, Newcombe NJ, Nowak T, Packer MJ, Plowright AT, Revill J, Schofield P, Sheldon C, Stokes S, Turnbull AV, Wang SJY, Whalley DP, Wood JM. 2012. Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg Med Chem Lett, 22 :3873-3878 >DOI >Link Scott JS, Birch AM, Brocklehurst KJ, Broo A, Brown HS, Butlin RJ, Clarke DS, Davidsson O, Ertan A, Goldberg K, Groombridge SD, Hudson JA, Laber D, Leach AG, Macfaul PA, McKerrecher D, Pickup A, Schofield P, Svensson PH, Sörme P, Teague J. 2012. Use of small-molecule crystal structures to address solubility in a novel series of G protein coupled receptor 119 agonists: optimization of a lead and in vivo evaluation. J Med Chem, 55 :5361-5379 >DOI >Link Birch AM, Groombridge S, Law R, Leach AG, Mee CD, Schramm C. 2012. Rationally designing safer anilines: the challenging case of 4-aminobiphenyls. J Med Chem, 55 :3923-3933 >DOI >Link