Giuntini, Francesca - Liverpool John Moores University - School of Pharmacy and Biomolecular Sciences

个人简介

I studied Medicinal Chemistry and Pharmaceutical Technologies in the Faculty of Pharmacy at the University of Florence (Florence, Italy), and I obtained my PhD from the University of Rome “La Sapienza”, working on cationic amphiphilic phthalocyanines for the photodynamic inactivation of microorganisms. After my PhD, I worked at Molteni Farmaceutici (Florence, Italy), where I was involved in a project concerning the synthesis of carboranyl-containing phthalocyanines as dual radio- and photo-sensitising agents for synergistic boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) of tumours: a collaboration between the University of Padova (Padua, Italy), the National Institute of Nuclear Physics (Rome, Italy), and Molteni Farmaceutici. From Florence, I moved to the University of Aveiro (Portugal) in the group of Prof J. Cavaleiro, to work on the functionalisation of tetra-arylporphyrins to yield conjugatable derivatives. Following this position, I joined the group of Dr. Ian Eggleston (University of Bath) and worked on the synthesis of peptide prodrugs of 5-aminolaevlinic acid (ALA) for the PDT of cancer and bacterial infections, and on the use of cell-penetrating peptides (CPPs) as delivery agents for ALA-containing dendrimers, quantum dots, and porphyrins. I then followed on to the University of Hull in the group of Prof. Ross Boyle, where I worked on novel polyacrylamide nanosensors to monitor intracellular calcium fluctuations in response to photodynamically induced generation of singlet oxygen. Since June 2013 I have been a Lecturer in Medicinal Chemistry in the School of Pharmacy and Biomolecular Sciences at Liverpool John Moores Unversity.

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Dondi R, Yaghini E, Tewari KM, Wang L, Giuntini F, Loizidou M, MacRobert AJ, Eggleston IM. 2016. Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy ORGANIC & BIOMOLECULAR CHEMISTRY, 14 :11488-11501 >DOI >Link Broughton LJ, Giuntini F, Savoie H, Bryden F, Boyle RW, Maraveyas A, Madden LA. 2016. Duramycin-porphyrin conjugates for targeting of tumour cells using photodynamic therapy JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 163 :374-384 >DOI >Link Chauhan VM, Giuntini F, Aylott JW. 2016. Quadruple labelled dual oxygen and pH-sensitive ratiometric nanosensors Sensing and Bio-Sensing Research, 8 :36-42 >DOI Frame FM, Savoie H, Bryden F, Giuntini F, Mann VM, Simms MS, Boyle RW, Maitland NJ. 2016. Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy include senescence, necrosis, and autophagy, but not apoptosis CANCER MEDICINE, 5 :61-73 >DOI >Link Lavado AS, Chauhan VM, Zen AA, Giuntini F, Jones DRE, Boyle RW, Beeby A, Chan WC, Aylott JW. 2015. Controlled intracellular generation of reactive oxygen species in human mesenchymal stem cells using porphyrin conjugated nanoparticles NANOSCALE, 7 :14525-14531 >DOI >Link Serpe L, Giuntini F. 2015. Sonodynamic antimicrobial chemotherapy: First steps towards a sound approach for microbe inactivation JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 150 :44-49 >DOI >Link Di Venosa G, Vallecorsa P, Giuntini F, Mamone L, Batlle A, Vanzuli S, Juarranz A, MacRobert AJ, Eggleston IM, Casas A. 2015. The use of dipeptide derivatives of 5-aminolaevulinic acid promotes their entry to tumor cells and improves tumor selectivity of photodynamic therapy Molecular Cancer Therapeutics, 14 :440-451 >DOI Duckles H, Boycott HE, Al-Owais MM, Elies J, Johnson E, Dallas ML, Porter KE, Giuntini F, Boyle JP, Scragg JL, Peers C. 2015. Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca2+ channels PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 467 :415-427 >DOI >Link Giuntini F, Chauhan VM, Aylott JW, Rosser GA, Athanasiadis A, Beeby A, MacRobert AJ, Brown RA, Boyle RW. 2014. Conjugatable water-soluble Pt(ii) and Pd(ii) porphyrin complexes: Novel nano- and molecular probes for optical oxygen tension measurement in tissue engineering Photochemical and Photobiological Sciences, 13 :1039-1051 >DOI Giuntini F, Bryden F, Daly R, Scanlan EM, Boyle RW. 2014. Huisgen-based conjugation of water-soluble porphyrins to deprotected sugars: Towards mild strategies for the labelling of glycans Organic and Biomolecular Chemistry, 12 :1203-1206 >DOI Yaghini E, Giuntini F, Eggleston IM, Suhling K, Seifalian AM, MacRobert AJ. 2014. Fluorescence lifetime imaging and FRET-induced intracellular redistribution of Tat-conjugated quantum dot nanoparticles through interaction with a phthalocyanine photosensitiser. Small, 10 :782-792 >DOI >Link Wang JT-W, Giuntini F, Eggleston IM, Bown SG, MacRobert AJ. 2012. Photochemical internalisation of a macromolecular protein toxin using a cell penetrating peptide-photosensitiser conjugate. J Control Release, 157 :305-313 >DOI >Link Silva EMP, Ramos CIV, Pereira PMR, Giuntini F, Faustino MAF, Tomé JPC, Tomé AC, Silva AMS, Santana-Marques MG, Neves MGPMS, Cavaleiro JAS. 2012. Cationic β-vinyl substituted meso-tetraphenylporphyrins: Journal of Porphyrins and Phthalocyanines, 16 :101-113 >DOI Giuntini F, Dumoulin F, Daly R, Ahsen V, Scanlan EM, Lavado ASP, Aylott JW, Rosser GA, Beeby A, Boyle RW. 2012. Orthogonally bifunctionalised polyacrylamide nanoparticles: a support for the assembly of multifunctional nanodevices. Nanoscale, 4 :2034-2045 >DOI >Link Webb C, Upadhyay A, Giuntini F, Eggleston I, Furutani-Seiki M, Ishima R, Bagby S. 2011. Structural features and ligand binding properties of tandem WW domains from YAP and TAZ, nuclear effectors of the Hippo pathway. Biochemistry, 50 :3300-3309 >DOI >Link Giuntini F, Alonso CMA, Boyle RW. 2011. Synthetic approaches for the conjugation of porphyrins and related macrocycles to peptides and proteins. Photochem Photobiol Sci, 10 :759-791 >DOI >Link Bourré L, Giuntini F, Eggleston IM, Mosse CA, Macrobert AJ, Wilson M. 2010. Effective photoinactivation of Gram-positive and Gram-negative bacterial strains using an HIV-1 Tat peptide-porphyrin conjugate. Photochem Photobiol Sci, 9 :1613-1620 >DOI >Link Moura NMM, Giuntini F, Faustino MAF, Neves MGPMS, Tomé AC, Silva AMS, Rakib EM, Hannioui A, Abouricha S, Röder B, Cavaleiroa JAS. 2010. 1,3-Dipolar cycloaddition of nitrile imines to mesotetraarylporphyrins Arkivoc, 2010 :24-33 Bourré L, Giuntini F, Eggleston IM, Wilson M, MacRobert AJ. 2009. Protoporphyrin IX enhancement by 5-aminolaevulinic acid peptide derivatives and the effect of RNA silencing on intracellular metabolism. Br J Cancer, 100 :723-731 >DOI >Link Giuntini F, Bourré L, MacRobert AJ, Wilson M, Eggleston IM. 2009. Improved peptide prodrugs of 5-ALA for PDT: rationalization of cellular accumulation and protoporphyrin IX production by direct determination of cellular prodrug uptake and prodrug metabolization. J Med Chem, 52 :4026-4037 >DOI >Link Giuntini F, Bourre L, Wilson M, MacRobert AJ, Eggleston IM. 2008. A novel approach to improve cellular delivery of 5-aminolaevulinic acid: New ALA-containing peptide Prodrugs for photodynamic therapy Journal of Peptide Science, 14 :156-156 Bourré L, Giuntini F, Eggleston IM, Wilson M, MacRobert AJ. 2008. 5-Aminolaevulinic acid peptide prodrugs enhance photosensitization for photodynamic therapy. Mol Cancer Ther, 7 :1720-1729 >DOI >Link Giuntini F, Bourré L, Macrobert AJ, Wilson M, Eggleston IM. 2008. Quantitative determination of 5-aminolaevulinic acid and its esters in cell lysates by HPLC-fluorescence. J Chromatogr B Analyt Technol Biomed Life Sci, 875 :562-566 >DOI >Link Izquierdo RA, Barros CM, Santana-Marques MG, Ferrer-Correia AJ, Silva EMP, Giuntini F, Faustino MAF, Tomé JPC, Tomé AC, Silva AMS, Neves GPMS, Cavaleiro JAS, Peixoto AF, Pereira MM, Pais AACC. 2007. Characterization of isomeric cationic porphyrins with beta-pyrrolic substituents by electrospray mass spectrometry: the singular behavior of a potential virus photoinactivator. J Am Soc Mass Spectrom, 18 :218-225 >DOI >Link Dei D, Chiti G, De Filippis MP, Fantetti L, Giuliani F, Giuntini F, Soncin M, Jori G, Roncucci G. 2006. Phthalocyanines as photodynamic agents for the inactivation of microbial pathogens Journal of Porphyrins and Phthalocyanines, 10 :147-159