个人简介
Christopher Coxon completed a Cancer Research UK funded PhD under the supervision of Professors Roger Griffin and Bernard Golding at the Northern Institute for Cancer Research, Newcastle University (2010). During this time he became involved with the design and synthesis of small molecule modulators of novel anti-cancer targets, specifically kinases and protein-protein interactions that are pivotal in oncogenic signaling.
Christopher then moved to Durham University in 2010 to work as a postdoctoral research associate in the areas of synthetic organic chemistry and chemical biology under Prof. Patrick Steel. In Oct 2012 he joined Dr Steven Cobb’s group as a senior PDRA, where he investigated routes to multicyclic peptides for application as protein-protein interaction inhibitors; as well as exploring the diverse chemistry of polyfluorinated (hetero)aromatics.
In 2013 Christopher began his independent research career as a temporary lecturer at Durham University, before being appointed to the position of Lecturer in Medicinal and Natural Products Chemistry at Liverpool John Moores University in October 2014.
研究领域
The themes underpinning our groups interests are of a multidisciplinary nature and fall broadly under the umbrella of organic and biological chemistry. We are specifically involved in the synthesis and application of chemical probes to understand complex biological problems and to unravel the key processes involved in diseases typically associated with ageing, including cancer, Alzheimer’s and inflammation. As such, we are developing novel tools to understand cellular signaling through protein-protein interactions (PPIs).
My research interests encompass a wide range of areas including synthetic organic chemistry and peptide chemistry to chemical biology. Specifically, my research focuses on the following areas:
a) Investigating new methodologies for the modification and functionalization of peptide side chains.
b) Investigating and utilising fluorine as a tool for chemical biology and controlling molecular conformation in the context of medicine and catalysis.
c) The synthesis of peptide and small molecule chemical tools to probe diseases e.g. cancer, with a view to developing new treatments.
Each of these strands are applied to the design and synthesis of cell-stable and deliverable peptides and peptide mimetics (stapled peptides, cyclic peptides and peptoids) in targeted drug discovery programmes. Current areas of research include:
a) Cancer – targeting the p53-MDM2 protein-protein interaction (collaboration with Prof. Martin Noble, Newcastle University)
b) Skeletal muscle regeneration and the effects of ageing (collaboration with Dr Adam Sharples, SES, LJMU)
c) Inflammation and the role of neutraceuticals in neuroprotection (collaboration with Dr Darren Sexton, PBS, LJMU)
近期论文
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Coxon CR. 2016. Structure-guided design of purine-based probes for selective Nek2 inhibition Oncotarget, >DOI
Coxon CR. 2016. Cyclin-Dependent Kinase (CDK) Inhibitors; Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines Journal of Medicinal Chemistry, >DOI >Link
Mitcheson DF, Bottrill AR, Carr K, Coxon CR, Cano C, Golding BT, Griffin RJ, Fry AM, Doerig C, Bayliss R, Tobin AB. 2016. A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase Malaria Journal, 15 :1-12 >DOI
Aguilar JA, Ball AT, Coxon CR, Kenwright AM, Lancaster RW, Mosely JA, Mutton MA. 2016. Amorphism and Thermal Decomposition of Salicylsalicylic Acid—A Cautionary Tale Journal of Pharmaceutical Sciences, 105 :3073-3078 >DOI
Tatum NJ, Yufit DS, Cobb SL, Coxon CR. 2015. Synthesis, Ni(II) Schiff base complexation and structural analysis of fluorinated analogs of the ligand (S)-2-[N-(N '-benzylprolyl)amino]benzophenone (BPB) JOURNAL OF FLUORINE CHEMISTRY, 173 :77-83 >DOI >Link
Carbain B, Coxon CR, Lebraud H, Elliott KJ, Matheson CJ, Meschini E, Roberts AR, Turner DM, Wong C, Cano C, Griffin RJ, Hardcastle IR, Golding BT. 2014. Trifluoroacetic acid in 2,2,2-trifluoroethanol facilitates S(N)Ar reactions of heterocycles with arylamines Chemistry (Weinheim an der Bergstrasse, Germany), 20 :2311-2317 >DOI
Webster AM, Coxon CR, Kenwright AM, Sandford G, Cobb SL. 2014. A mild method for the synthesis of a novel dehydrobutyrine-containing amino acid TETRAHEDRON, 70 :4661-4667 >DOI >Link
Carbain B, Coxon CR, Lebraud H, Elliott KJ, Matheson CJ, Meschini E, Roberts AR, Turner DM, Wong C, Cano C, Griffin RJ, Hardcastle IR, Golding BT. 2014. Trifluoroacetic acid in 2,2,2-trifluoroethanol facilitates SNAr reactions of heterocycles with arylamines Chemistry - A European Journal, 20 :2311-2317 >DOI
Lebraud H, Coxon CR, Archard VS, Bawn CM, Carbain B, Matheson CJ, Turner DM, Cano C, Griffin RJ, Hardcastle IR, Baisch U, Harrington RW, Golding BT. 2014. Model system for irreversible inhibition of Nek2: Thiol addition to ethynylpurines and related substituted heterocycles Organic and Biomolecular Chemistry, 12 :141-148 >DOI
Hudson AS, Hoose A, Coxon CR, Sandford G, Cobb SL. 2013. Synthesis of a novel tetrafluoropyridine-containing amino acid and tripeptide TETRAHEDRON LETTERS, 54 :4865-4867 >DOI >Link
Cummins I, Wortley DJ, Sabbadin F, He Z, Coxon CR, Straker HE, Sellars JD, Knight K, Edwards L, Hughes D, Kaundun SS, Hutchings SJ, Steel PG, Edwards R. 2013. Key role for a glutathione transferase in multiple-herbicide resistance in grass weeds Proceedings of the National Academy of Sciences of the United States of America, 110 :5812-5817 >DOI
Blackburn TJ, Ahmed S, Coxon CR, Liu J, Lu X, Golding BT, Griffin RJ, Hutton C, Newell DR, Ojo S, Watson AF, Zaytzev A, Zhao Y, Lunec J, Hardcastle IR. 2013. Diaryl- and triaryl-pyrrole derivatives: Inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions MedChemComm, 4 :1297-1304 >DOI
Coxon CR. 2015. Perfluoroaryl-stapled peptides: Inhibitors of the p53-MDM2 protein-protein interaction Royal Society of Chemistry, Organic Division, North West Regional Meeting
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