Savva, Renos - Birkbeck, University of London - Department of Biological Sciences

研究领域

Research focus is in viruses of eukaryotes and prokaryotes. This includes the structural biology of essential activities from viruses, particularly relating to protein-protein and protein-nucleic acid interactions in DNA repair and replication. Research is also focused upon synthetic biology as applied to bacteriophages, for their repurposing with applications in cellular reprogramming. Current research projects including collaborations and translational activities, encompass: Characterisation of human Herpesvirus replication and latency associated proteins Genomics and structural studies of bacteriophages including novel protein activities Using synthetic biology to enable protein structure prediction from sequence data Synthetic biology involving bacteriophage

近期论文

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Cole, Ambrose R. and Ofer, Sapir and Ryzhenkova, Ksenia and Baltulionis, Gediminas and Hornyak, Peter and Savva, Renos (2013) Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase. Nucleic Acids Research 41 (18), pp. 8760-8775. ISSN 0305-1048. Meier, C. and Brookings, D.C. and Ceska, T.A. and Doyle, C. and Gong, H. and McMillan, D. and Saville, G.P. and Mushtaq, A. and Knight, D. and Reich, S. and Pearl, L.H. and Powell, K.A. and Savva, Renos and Allen, R.A. (2012) Engineering human MEK-1 for structural studies: a case study of combinatorial domain hunting. Journal of Structural Biology 177 (2), pp. 329-334. ISSN 1047-8477. Fogl, C. and Puckey, Loretto and Hinssen, U. and Zaleska, M. and el-Mezgueldi, M. and Croasdale, R. and Bowman, A. and Matsukawa, A. and Samani, N.J. and Savva, Renos and Pfuhl, M. (2012) A structural and functional dissection of the cardiac stress response factor MS1. Proteins: Structure, Function, and Bioinformatics 80 (2), pp. 398-409. ISSN 0887-3585. Bagneris, Claire and Briggs, Louise C. and Savva, Renos and Ebrahimi, B. and Barrett, Tracey E. (2011) Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff. Nucleic Acids Research 39 (13), pp. 5744-5756. ISSN 0305-1048. Maclagan, K. and Tommasi, R. and Laurine, E. and Prodromou, C. and Driscoll, P.C. and Pearl, L.H. and Reich, S. and Savva, Renos (2011) A combinatorial method to enable detailed investigation of protein-protein interactions. Future Medicinal Chemistry 3 (3), pp. 271-282. ISSN 1756-8919. dos Reis, M. and Savva, Renos and Wernisch, Lorenz (2004) Solving the riddle of codon usage preferences: a test for translational selection. Nucleic Acids Research 32 (17), pp. 5036-5044. ISSN 0305-1048. dos Reis, M. and Wernisch, Lorenz and Savva, Renos (2003) Unexpected correlations between gene expression and codon usage bias from microarray data for the whole Escherichia coli K-12 genome. Nucleic Acids Research 31 (23), pp. 6976-6985. ISSN 0305-1048.