Marson, Charles - University College London

个人简介

Charles Marson is Professor of Organic Chemistry. Currently, his research group includes 5 PhD students and a Masters student. His areas of research include organic synthesis, especially the development of stereocontrolled reactions, cascade processes and asymmetric synthesis. Another major research theme is and the design and synthesis of enzyme inhibitors. Charles Marson received his B.A. and M.A. degrees in Natural Sciences from the University of Cambridge, and PhD and DSc degrees from the University of East Anglia. His PhD research under the direction of Professor A. R. Katritzky, FRS on the synthesis of polycyclic heterocycles afforded the synthesis of the first bispyrylium macrocycle of twelve fused rings. After postdoctoral research he was appointed to Lectureships at the University of Sheffield and Queen Mary College, University of London before appointments at UCL as a Reader, and in 2004 as Professor or Organic Chemistry.

研究领域

Organic Chemistry and Chemical Biology

Synthetic methodology: tandem and stereocontrolled processes Catalytic asymmetric synthesis Synthesis of fused and bridged scaffolds for medicinal chemistry Medicinal chemistry: synthesis of anti-cancer agents and enzyme inhibitors

近期论文

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Dines, J. A., & Marson, C. M. (2016). A direct alkylation route to branched derivatives of suberoylanilide hydroxamic acid (SAHA), a potent non-selective inhibitor of histone deacetylases. Tetrahedron, 72 (52), 8584-8592. doi:10.1016/j.tet.2016.11.039 Promontorio, R., Richard, J. -. A., & Marson, C. M. (2016). Domino Michael-aldol annulations for the stereocontrolled synthesis of bicyclo[3.3.1]nonane and bicyclo[3.2.1]octane derivatives. RSC Adv., 6 (115), 114412-114424. doi:10.1039/C6RA23523A Greenwood, S. O. R. (2015). Design and evaluation of novel histone deacetylase 8 inhibitors (Doctoral dissertation). UCL (University College London). Marson, C. M., Matthews, C. J., Atkinson, S. J., Lamadema, N., & Thomas, N. S. B. (2015). Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit. JOURNAL OF MEDICINAL CHEMISTRY, 58 (17), 6803-6818. doi:10.1021/acs.jmedchem.5b00545 Ferretti, P., Pong, K. U., Vagaska, B., Merchant, R., Matthews, C. J., & Marson, C. M. (2013). Discovery of a structurally novel, drug-like and potent inhibitor of peptidylarginine deiminase. MEDCHEMCOMM, 4 (7), 1109-1113. doi:10.1039/c3md00091e Marson, C. M., Matthews, C. J., Yiannaki, E., Atkinson, S. J., Soden, P. E., Shukla, L., . . . Thomas, N. S. B. (2013). Discovery of Potent, Isoform-Selective Inhibitors of Histone Deacetylase Containing Chiral Heterocyclic Capping Groups and a N-(2-Aminophenyl)benzamide Binding Unit. JOURNAL OF MEDICINAL CHEMISTRY, 56 (15), 6156-6174. doi:10.1021/jm400634n Ostovar, M., & Marson, C. M. (2013). Enynone dihydroxylation-cyclisation as a route to densely functionalised 3(2H)-furanone derivatives: an approach to the core of the zaragozic acids. TETRAHEDRON, 69 (32), 6639-6647. doi:10.1016/j.tet.2013.05.125 Maharaj, L., Marson, C. M., Middleton, B. J., Rioja, A. S., Perry, J., Oakervee, H., . . . Popat, R. (2013). The histone deacetylase inhibitor UCL67022 has potent activity in multiple myeloma and non-Hodgkin lymphoma pre-clinical models. Br J Haematol, 163 (1), 135-139. doi:10.1111/bjh.12456 Marson, C. M. (2012). Multicomponent and sequential organocatalytic reactions: diversity with atom-economy and enantiocontrol. CHEMICAL SOCIETY REVIEWS, 41 (23), 7712-7722. doi:10.1039/c2cs35183h Marson, C. M. (2011). New and unusual scaffolds in medicinal chemistry. CHEMICAL SOCIETY REVIEWS, 40 (11), 5514-5533. doi:10.1039/c1cs15119c Marson, C. M. (2011). Targeting the Histamine H-4 Receptor. CHEMICAL REVIEWS, 111 (11), 7121-7156. doi:10.1021/cr900166w Assem, E. S. K., Mann, S., Wan, B. Y. C., & Marson, C. M. (2010). Effect of antioxidants on airway smooth muscle contraction: action of lipoic acid and some of its novel derivatives on guinea pig tracheal smooth muscle. INFLAMMATION RESEARCH, 59, 235-237. doi:10.1007/s00011-009-0137-0 Wan, B. Y. C., Mann, S., Assem, E. S. K., & Marson, C. M. (2010). Effect of endogenous and synthetic antioxidants on hydrogen peroxide-induced guinea-pig colon contraction. INFLAMMATION RESEARCH, 59, 231-233. doi:10.1007/s00011-009-0136-1 Assem, E. -. S., Mann, S., Wan, B. Y. C., & Marson, C. M. (n.d.). Effect of some lipoic acid derivatives and other antioxidants on the histamine-induced guinea-pig tracheal smooth muscle contraction. Assem, E. -. S., Peh, K. H., Wan, B. Y., Dines, J., Middleton, J. B., & Marson, C. M. (2009). Effects of a selection of histone deacetylase inhibitors on the antigen- and agonist(s)-induced tracheal smooth muscle contraction. Inflammation Research, 58, S22-S23. Marson, C. M. (2009). Histone Deacetylase Inhibitors: Design, Structure-Activity Relationships and Therapeutic Implications for Cancer. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 9 (6), 661-692. MARSON, C. (2009). Mode of Action of Histone Deacetylase Inhibitors on Mast Cell Histamine Release and Colon Muscle Contraction. Inflammation Research, 58, S24-S25. Assem, E. -. S. K., Peh, K. H., Wan, B. Y. C., Middleton, B. J., Dines, J., & Marson, C. M. (2008). Effects of a selection of histone deacetylase inhibitors on mast cell activation and airway and colonic smooth muscle contraction. INTERNATIONAL IMMUNOPHARMACOLOGY, 8 (13-14), 1793-1801. doi:10.1016/j.intimp.2008.08.017 Joel, S. P., & Marson, C. M. (2008). Histone deacetylase inhibitors. Kwok, J. M. -. M., Myatt, S. S., Marson, C. M., Coombes, R. C., Constantinidou, D., & Lam, E. W. -. F. (2008). Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression. MOLECULAR CANCER THERAPEUTICS, 7 (7), 2022-2032. doi:10.1158/1535-7163.MCT-08-0188 Marson, C. M., Edaan, E., Morrell, J. M., Coles, S. J., Hursthouse, M. B., & Davies, D. T. (2007). A catalytic asymmetric protocol for the enantioselective synthesis of 3(2H)-furanones. Chemical Communications, 24, 2494-2496. doi:10.1039/b701548h Marson, C. M., Mahadevan, T., Dines, J., Sengmany, S., Morrell, J. M., Alao, J. P., . . . Coombes, R. C. (2007). Structure-activity relationships of aryloxyalkanoic acid hydroxyamides as potent inhibitors of histone deacetylase. Bioorganic and Medicinal Chemistry Letters, 17 (1), 136-141. doi:10.1016/j.bmcl.2006.09.085 Marson, C. M., Edaan, E., Coles, S. J., Morrell, J. M., Hursthouse, M. B., & Davies, D. T. (n.d.). A catalytic asymmetric protocol for the enantioselective synthesis of 3(2H)-furanones. Marson, C. M., Savy, P., Rioja, A. S., Mahadevan, T., Mikol, C., Veerupillai, A., . . . Joel, S. P. (2006). Aromatic Sulfide Inhibitors of Histone Deacetylase based on Arysulfinyl-2,4-dienoic Acid Hydroxyamides. Journal of Medicinal Chemistry, 49, 800-805. doi:10.1021/jm051010j Marson, C. M., Mahadevan, T., Dines, J., Sengmany, S., Morrell, J. M., Alao, J. P., . . . Coombes, R. C. (2006). Stereodefined and Structure-Activity Relationships of Aryloxyalkanoic acid Hydroxyamides as Potent Inhibitors of Histone Deacetylase. BIOORG MED CHEM LETT, 16.