Orlova, Elena - Birkbeck, University of London - Department of Biological Sciences

研究领域

Bacteriophage assembly: Bacteriophage connector, Bacteriophage SPP1 connector-tail complex, Bacteriophage Capsid Structural analysis of the transcription factor p53: p53 tumour suppressor Human MCM10 replication factor Electron cryo-microscopy and image processing Development of methods for recognition and separation of heterogeneous molecular complexes

近期论文

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White HE, Sherman MB, Brasils S, Jacquet E, Seavers P, Tavares P, Orlova EV. (2012) Capsid structure and its Stability at the Late Stages of Bacteriophage SPP1 Assembly. J Virol. Apr 18. [Epub ahead of print] Orlova EV, (2011), Bacteriophages and their structural organisation. In Bacteriophages, (Ed. Kurtboke) InTech Open, open access publisher,3-30. Tavares P., Zinn-Justin S., and Orlova, E.V. (2011). Genome gating in tailed bacteriophage capsids. In Viral Molecular Machines (M.G. Rossmann, V.B. Rao, eds.), Springer, New York, 585-600 (1) Orlova EV, Saibil HR, (2011) Structural analysis of macromolecular assemblies by electron microscopy. Chemical Reviews, 111(12), 7710-7748 (2) R. Aramayo, M. B. Sherman, K. Brownless, A. L. Okorokov and E. V. Orlova. (2011) Quaternary structure of the specific p53-DNA complex reveals the mechanism of p53 mutant dominance. NAR, 39 (20), 8960-8971 (1). Law RHP, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, Angelo MED, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird FI, Trapani JA, Saibil HR, Whisstock JC. (2010) The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature, 468, 447-51.(23) Orlova EV, Saibil HR.(2010) Methods for three-dimensional reconstruction of heterogeneous assemblies. Methods Enzymol.,482, 321-41, Review.(5) Clare DK, Orlova EV. (2010)4.6A Cryo-EM reconstruction of tobacco mosaic virus from images recorded at 300keV on a 4kx4k CCD camera. J Struct Biol. 171, 303-308. (7) Okorokov AL, Chaban YL, Bugreev DV, Hodgkinson J, Mazin AV, Orlova EV. Structure of the hDmc1-ssDNA filament reveals the principles of its architecture. (2010) PLoS One. 5(1):e8586 (4) Lhuillier S, Gallopin M, Gilquin B, Brasils S, Lancelot N, Letellier G, Gilles M, Dethan G, Orlova EV, Couprie J, Tavares P, Zinn-Justin S. (2009) Structure of bacteriophage SPP1 head-to-tail connection reveals mechanism for viral DNA gating. Proc Natl Acad Sci USA. 106(21), 8507-8512. Orlova EV. How viruses infect bacteria? (2009) EMBO J. 28(7), 797-798. White HE, Hodgkinson JL, Jahn TR, Cohen-Krausz S, Gosal WS, Muller S, Orlova EV, Radford SE, Saibil HR. (2009) Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils. J. Mol Biol. 389(1), 48-57. Okorokov AL, Orlova EV. (2009) Structural biology of the p53 tumour suppressor. Curr Opin Struct Biol. 19(2), 97-202. Review. Fronzes R, Schafer E, Wang L, Saibil HR, Orlova EV, Waksman G. (2009) Structure of a type IV secretion system core complex. Science. 323(5911), 266-268. Salih O, Remaut H, Waksman G, Orlova EV. (2008) Structural analysis of the Saf pilus by electron microscopy and image processing. J Mol Biol. 23, 174-187 Elad N, Clare DK, Saibil HR, Orlova EV. (2008) Detection and separation of heterogeneity in molecular complexes by statistical analysis of their two-dimensional projections. J Struct Biol. 162, 108-120