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个人简介

Derek Macmillan is Reader in Organic Chemistry. His group is multidisciplinary and currently consists of 1 postdoc, 3 PhD students and 2 MRes students. He was worked at UCL since 2005 (2005-11: Royal Society University Research Fellow; 2011-present: Reader). Before this, he was a postdoctoral research associate at UC Berkeley, working with Professor Carolyn Bertozzi.

研究领域

Organic Chemistry and Chemical Biology

Peptide Synthesis Carbohydrate Chemistry Chemical Ligation Protein Engineering Therapeutic peptides, proteins, and glycoproteins

近期论文

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Chen, W., Kinsler, V. A., Macmillan, D., & Di, W. L. (2016). Tissue kallikrein inhibitors based on the sunflower trypsin inhibitor scaffold - A potential therapeutic intervention for skin diseases. PLoS ONE, 11 (11). doi:10.1371/journal.pone.0166268 Cowper, B., Sze, T. M., Premdjee, B., White, A. F. B., Hacking, A., & Macmillan, D. (2015). Examination of mercaptobenzyl sulfonates as catalysts for native chemical ligation: application to the assembly of a glycosylated Glucagon-Like Peptide 1 (GLP-1) analogue. CHEMICAL COMMUNICATIONS, 51 (15), 3208-3210. doi:10.1039/c4cc09502b Cowper, B., Shariff, L., Chen, W., Gibson, S. M., Di, W. -. L., & Macmillan, D. (2015). Expanding the scope of N -> S acyl transfer in native peptide sequences. ORGANIC & BIOMOLECULAR CHEMISTRY, 13 (27), 7469-7476. doi:10.1039/c5ob01029b Shariff, L. S., & Macmillan, D. (2014). Retro-native chemical ligation rings in the changes for therapeutic peptides. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 248. AMER CHEMICAL SOC. Shariff, L., Cowper, B., Macmillan, D., Zhu, Y., & Di, W. -. L. (2014). Sunflower trypsin inhibitor (SFTI-1) analogues of synthetic and biological origin via N→S acyl transfer: potential inhibitors of human Kallikrein-5 (KLK5). Tetrahedron. doi:10.1016/j.tet.2014.06.059 Cowper, B., Craik, D. J., & Macmillan, D. (2013). Chemically-mediated Circularisation of Recombinant Proteins. BIOPOLYMERS, 100 (3), 226. Macmillan, D., Adams, A. L., Cowper, B., Morgan, R. E., Premdjee, B., & Caddick, S. (2013). Cysteine Promoted C-Terminal Hydrazinolysis of Native Peptides and Proteins. . doi:10.1002/anie.201304997 Adams, A. L., Srai, S. K., & Macmillan, D. (2013). Hepcidin, a Challenging Arena for Developing New Ligation Methodology. BIOPOLYMERS, 100 (3), 311-312. Adams, A. L., & Macmillan, D. (2013). Investigation of peptide thioester formation via N→Se acyl transfer. J Pept Sci, 19 (2), 65-73. doi:10.1002/psc.2469 Cowper, B., Craik, D. J., & Macmillan, D. (2013). Making ends meet: chemically mediated circularization of recombinant proteins. Chembiochem, 14 (7), 809-812. doi:10.1002/cbic.201300105 Adams, A., Macmillan, D., Pizzey, A., & Srai, K. (2013). STRATEGIES FOR THE SYNTHESIS OF HEPCIDIN AND ANALOGUES. AMERICAN JOURNAL OF HEMATOLOGY, 88 (5), E228-E229. Currie, S. M., Findlay, E. G., McHugh, B. J., Mackellar, A., Man, T., Macmillan, D., . . . Davidson, D. J. (2013). The Human Cathelicidin LL-37 Has Antiviral Activity against Respiratory Syncytial Virus. PLOS ONE, 8 (8), ARTN e73659. doi:10.1371/journal.pone.0073659 Harvey, S. R., Porrini, M., Stachl, C., MacMillan, D., Zinzalla, G., & Barran, P. E. (2012). Small-Molecule Inhibition of c-MYC:MAX Leucine Zipper Formation Is Revealed by Ion Mobility Mass Spectrometry. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134 (47), 19384-19392. doi:10.1021/ja306519h Jungmichel, S., Clapperton, J. A., Lloyd, J., Hari, F. J., Spycher, C., Pavic, L., . . . Smerdon, S. J. (2012). The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator. Nucleic Acids Research, 40 (9), 3913-3928. doi:10.1093/nar/gkr1300 Kajihara, Y., Izumi, M., Hirano, K., Murase, T., Macmillan, D., & Okamoto, R. (2011). Elucidating the Function of Complex-Type Oligosaccharides by Use of Chemical Synthesis of Homogeneous Glycoproteins. ISRAEL JOURNAL OF CHEMISTRY, 51 (8-9), 917-929. doi:10.1002/ijch.201100081 Premdjee, B., Adams, A. L., & Macmillan, D. (2011). Native N-glycopeptide thioester synthesis through N→S acyl transfer. Bioorg Med Chem Lett, 21 (17), 4973-4975. doi:10.1016/j.bmcl.2011.05.059 Adams, A., & Macmillan, D. (2011). Peptide Thioesters via N -> Se Acyl Transfer. BIOPOLYMERS, 96 (4), 437. WILEY-BLACKWELL. Richardson, J. P., & Macmillan, D. (2011). Semi-Synthesis of glycoproteins from E. coli through native chemical ligation. In T. C. Evans, M. -. Q. Xu (Eds.), Heterologous Gene Expression in E.coli (pp. 151-174). doi:10.1007/978-1-61737-967-3_9 Hirano, K., Izumi, M., Macmillan, D., Tezuka, K., Tsuji, T., & Kajihara, Y. (2011). Semisynthesis of Erythropoietin Analog Having Three Oligosaccharides. JOURNAL OF CARBOHYDRATE CHEMISTRY, 30 (4-6), 306-319. doi:10.1080/07328303.2011.604570 Macmillan, D., Adams, A., & Premdjee, B. (2011). Shifting Native Chemical Ligation into Reverse through N?S Acyl Transfer. ISRAEL JOURNAL OF CHEMISTRY, 51 (8-9), 885-899. doi:10.1002/ijch.201100084 Macmillan, D., De Cecco, M., Reynolds, N. L., Santos, L. F., Barran, P. E., & Dorin, J. R. (2011). Synthesis of cyclic peptides through an intramolecular amide bond rearrangement. Chembiochem, 12 (14), 2133-2136. doi:10.1002/cbic.201100364 Masania, J., Li, J., Smerdon, S. J., & Macmillan, D. (2010). Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N→S acyl transfer. Org Biomol Chem, 8 (22), 5113-5119. doi:10.1039/c0ob00363h McCullough, B. J., Kalapothakis, J. M., Chin, W., Taylor, K., Clarke, D. J., Eastwood, H., . . . Barran, P. E. (2010). Binding a heparin derived disaccharide to defensin inspired peptides: insights to antimicrobial inhibition from gas-phase measurements. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 12 (14), 3589-3596. doi:10.1039/b923784d De Cecco, M., Seo, E. S., Clarke, D. J., McCullough, B. J., Taylor, K., Macmillan, D., . . . Barran, P. E. (2010). Conformational Preferences of Linear beta-Defensins Are Revealed by Ion Mobility-Mass Spectrometry. JOURNAL OF PHYSICAL CHEMISTRY B, 114 (6), 2312-2318. doi:10.1021/jp9111662 Richardson, J. P., Chan, C. H., Blanc, J., Saadi, M., & Macmillan, D. (2010). Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N-->S acyl transfer. Org Biomol Chem, 8 (6), 1351-1360. doi:10.1039/b920535g

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