Keep, Nicholas - Birkbeck, University of London - Department of Biological Sciences

研究领域

Professor Keep's research uses macromolecular crystallography and, in collaboration with colleagues at the Institute of Structural and Molecular Biology (ISMB), single particle electron microscopy and NMR to understand biological function. Professor Keep says: 'My current major focus is on the proteins implicated in dormancy and resucitation in mycobacterium tuberculosis and in proteins involved in muscular dystrophy. I am always interested in collaborations with other groups on new structural biology projects.'

近期论文

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Quay, Doris H.X. and Cole, Ambrose R. and Cryar, A. and Thalassinos, Konstantinos and Williams, Mark A. and Bhakta, Sanjib and Keep, Nicholas H. (2015) Structure of the stationary phase survival protein YuiC from B.subtilis. BMC Structural Biology 15 (12), ISSN 1472-6807. Lichman, B.R. and Gershater, M.C. and Lamming, E.D. and Pesnot, T. and Sula, Altin and Keep, Nicholas H. and Hailes, H.C. and Ward, J.M. (2015) 'Dopamine-first' mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile. FEBS Journal 282 (6), pp. 1137-1151. ISSN 1742-464X. Chauviac, Francois-Xavier and Robertson, Giles and Quay, Doris H.X. and Bagneris, Claire and Dumas, C. and Henderson, B. and Ward, J. and Keep, Nicholas H. and Cohen-Gonsaud, Martin (2014) RpfC (Rv1884) atomic structure shows high structural conservation within the resuscitation promoting factor catalytic domain. Acta Crystallographica Section F: Structural Biology Communications F70 (8), pp. 1022-1026. ISSN 1744-3091. Sula, Altin and Cole, Ambrose R. and Yeats, C. and Orengo, C. and Keep, Nicholas H. (2014) Crystal structures of the human Dysferlin inner DysF domain. BMC Structural Biology 14 (3), ISSN 1472-6807. Zihni, C. and Munro, P.M.G. and Elbediwy, A. and Keep, Nicholas H. and Terry, S.J. and Harris, J. and Balda, M.S. and Matter, K. (2013) Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation. The Journal of Cell Biology 204 (1), pp. 111-127. ISSN 0021-9525. Munshi, Tulika and Gupta, Antima and Evangelopoulos, Dimitrios and Guzman, Juan D. and Gibbons, S. and Keep, Nicholas H. and Bhakta, Sanjib (2013) Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis. PLoS One 8 (3), e60143. ISSN 1932-6203. Chauviac, Francois-Xavier and Bommer, M. and Yan, Jun and Parkin, G. and Daviter, Tina and Lowden, Philip A.S. and Raven, E. L. and Thalassinos, Konstantinos and Keep, Nicholas H. (2012) Crystal structure of reduced MsAcg a putative nitroreductase from Mycobacterium smegmatis, and a close homologue of Mycobacterium tuberculosis Acg. Journal of Biological Chemistry 287 , pp. 44372-44383. ISSN 0021-9258. Evangelopoulos, Dimitrios and Cronin, Nora and Daviter, Tina and Sim, E. and Keep, Nicholas H. and Bhakta, Sanjib (2011) Characterization of an oxidoreductase from the arylamine N-acetyltransferase operon in Mycobacterium Smegmatis. FEBS Journal 278 (24), pp. 4824-4832. ISSN 1742-464X. Clark, Alice R. and Naylor, Claire E. and Bagneris, Claire and Keep, Nicholas H. and Slingsby, Christine (2011) Crystal structure of R120G disease mutant of human αB-Crystallin Domain Dimer shows closure of a groove. Journal of Molecular Biology 408 (1), pp. 118-134. ISSN 0022-2836. Basavannacharya, Chandrakala and Moody, P.R. and Munshi, T. and Cronin, Nora and Keep, Nicholas H. and Bhakta, Sanjib (2010) Essential residues for the enzyme activity of ATP-dependent MurE ligase from Mycobacterium tuberculosis. Protein & Cell 1 (11), pp. 1011-1022. ISSN 1674-800X. Basavannacharya, Chandrakala and Robertson, Giles and Munshi, T. and Keep, Nicholas H. and Bhakta, Sanjib (2010) ATP-dependent MurE ligase in Mycobacterium tuberculosis: biochemical and structural characterisation. Tuberculosis 90 (1), pp. 16-24. ISSN 1472-9792. Bagneris, Claire and Bateman, Orval A. and Naylor, Claire E. and Cronin, Nora and Boelens, W.C. and Keep, Nicholas H. and Slingsby, Christine (2009) Crystal structures of α-Crystallin Domain Dimers of αB-Crystallin and Hsp20. Journal of Molecular Biology 392 (5), pp. 1242-1252. ISSN 0022-2836. Zhou, J.J. and Robertson, Giles and He, X. and Dufour, S. and Hooper, A.M. and Pickett, J.A. and Keep, Nicholas H. and Field, L.M. (2009) Characterisation of Bombyx mori odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components. Journal of Molecular Biology 389 (3), pp. 529-545. ISSN 0022-2836. Patel, P. and Harris, R. and Geddes, Stella M. and Strehle, E.M. and Watson, J.D. and Bashir, R. and Bushby, K. and Driscoll, P.C. and Keep, Nicholas H. (2008) Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b. Journal of Molecular Biology 379 (5), pp. 981-990. ISSN 0022-2836. Garg, R. and Riento, K. and Keep, Nicholas H. and Morris, J.D.H. and Ridley, A.J. (2008) N-terminus-mediated dimerization of ROCK-1 is required for RhoE binding and actin reorganization. Biochemical Journal 411 , pp. 407-414. ISSN 0264-6021. Cohen Gonsaud, M. and Barthe, P. and Bagneris, Claire and Henderson, B. and Ward, J.M. and Roumestand, C. and Keep, Nicholas H. (2005) The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes. Nature Structural and Molecular Biology 12 (3), pp. 270-273. ISSN 1545-9993. Harvey, K. and Duguid, I.C. and Alldred, M.J. and Beatty, S.E. and Ward, H. and Keep, Nicholas H. and Lingenfelter, S.E. and Pearce, B.R. and Lundgren, J.D. and Owens, Max J. and Smart, T.G. and Luscher, B. and Rees, M.I. and Harvey, R.J. (2004) The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering. The Journal of Neuroscience 24 (25), pp. 5816-5826. ISSN 0270-6474. Cohen Gonsaud, M. and Barthe, P. and Pommier, F. and Harris, R. and Driscoll, P.C. and Keep, Nicholas H. and Roumestand, C. (2004) Letter to the Editor: 1H, 15N, and 13C chemical shift assignments of the resuscitation promoting factor domain of Rv1009 from Mycobacterium tuberculosis. Journal of Biomolecular NMR 30 (3), pp. 373-374. ISSN 0925-2738. Cohen Gonsaud, M. and Keep, Nicholas H. and Davies, A.P. and Ward, J.M. and Henderson, B. and Labesse, G. (2004) Resuscitation-promoting factors possess a lysozyme-like domain. Trends in Biochemical Sciences 29 (1), pp. 7-10. ISSN 0968-0004.