Hayward, Richard - Birkbeck, University of London - Department of Biological Sciences

研究领域

The Hayward-Lab's current research addresses the molecular cell biology of bacterial pathogenesis using a combination of biochemical, cell biology and imaging approaches. In particular we study the obligate intracellular bacterial pathogen Chlamydia trachomatis, the principal cause of sexually transmitted disease and infertility in the Western world and preventable blindness (trachoma) in developing nations.

近期论文

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Nans, Andrea and Kudryashev, M. and Saibil, Helen R. and Hayward, Richard (2015) Structure of a bacterial type III secretion system in contact with a host membrane in situ. Nature Communications, ISSN 2041-1723. (in press) Nans, Andrea and Ford, Charlotte and Hayward, Richard (2015) Host-pathogen reorganisation during host cell entry by Chlamydia trachomatis. Microbes and Infection, ISSN 1286-4579. (in press) Item availability may be restricted. Dumoux, Maud and Menny, Anais and Delacour, D. and Hayward, Richard (2015) A Chlamydia effector recruits CEP170 to reprogram host microtubule organization. Journal of Cell Science 128 , pp. 3420-3434. ISSN 0021-9533. (in press) Dumoux, Maud and Nans, Andrea and Saibil, Helen R. and Hayward, Richard (2015) Making connections: snapshots of chlamydial type III secretion systems in contact with host membranes. Current Opinion in Microbiology 23 pp. 1-7. ISSN 1369-5274. Nans A, Saibil HR, Hayward RD (2014) Pathogen-host reorganisation during Chlamydia invasion revealed by cryo-electron tomography. Cellular Microbiology, doi:10.1111/cmi.12310 Dumoux M, Le Gall SM, Habbeddine M, Delarbre C, Hayward RD, Kanellopoulos-Langevin C, Verbeke P (2013) Penicillin kills Chlamydia following the fusion of bacteria with lysosomes and prevents genital inflammatory lesions in C.muridarum-infected mice. PLoS One 8: e83511 Dumoux M, Clare DK, Saibil HR, Hayward RD (2012) Chlamydiae assemble a pathogen synapse to hijack the host endoplasmic reticulum Traffic 13:1612-1627 Brinkworth AJ, Malcolm DS, Pedrosa AT, Roguska K, Shahbazian S, Graham JE, Hayward RD, Carabeo RA (2011) Chlamydia trachomatis Slc1 is a type III secretion chaperone that enhances the translocation of its invasion effector substrate TARP. Molecular Microbiology 82: 131-144 Hayward RD, Goguen JD, Leong JM (2010) No better time to FRET: shedding light on host pathogen interactions. Journal of Biology 9: 1 Hayward RD, Hume PJ, Humphreys D, Phillips N, Smith K, Koronakis V (2009) Clustering transfers the translocated Escherichia coli receptor into lipid rafts to stimulate reversible activation of c-Fyn. Cellular Microbiology 11: 433-441 Campellone KG, Cheng HC, Robbins D, Siripala AD, McGhie EJ, Hayward RD, Welch MD, Rosen MK, Koronakis V, Leong JM (2008) Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly. PLoS Pathogens 4: e1000191 Cain RJ*, Hayward RD*, Koronakis V (2008) Deciphering interplay between Salmonella invasion effectors. PLoS Pathogens 4: e1000037