Cabreiro, Filipe Gomes - Birkbeck, University of London

个人简介

Filipe Cabreiro obtained his undergraduate degree in Applied Biochemistry from the University of Porto, Portugal. Following the success of his undergraduate studies, he qualified for a research fellowship from the French government. During Filipe’s Masters and PhD in Biochemistry at the Université Paris Diderot in France, he exploited the biological mechanisms underlying molecular stress protection and zinc homeostasis (Cabreiro et al., JBC 2008; Cabreiro et al., Antiox redox signal. 2009). In 2008, Filipe joined the group of Dr David Gems within the Institute of Healthy Ageing (IHA)/GEE at UCL as a post-doctoral researcher. Since this time, Filipe has broadened his background knowledge in several key areas such as genetics, molecular biology, metabolism and microbiology. Indeed, he undertook several projects simultaneously to investigate different aspects of ageing. These topics included the role of antioxidant metabolism and signaling in ageing (Cabreiro et al., Free Radic. Biol. Med. 2011), the role of sirtuins in ageing and disease (Cabreiro et al., Nature 2011), and the role of the anti-diabetic drug metformin in C. elegans metabolism and ageing (Cabreiro et al., Cell 2013). This final work has led onto developing a focus on host-microbiota interactions and metabolic disorders. Filipe has become an expert in a new model organism system, C. elegans and is pioneering the study of drug-microbiota interactions using this model (Cabreiro and Gems, EMBO Molec. Med. 2013). He is currently a Sir Henry Dale Fellow at the Institute of Structural and Molecular Biology at UCL after being awarded a fellowship from the Royal Society/Wellcome Trust to explore the gut microbial action of metformin and develop strategies to target the microbiota to treat metabolic disease. In terms of public engagement, Filipe was involved in the “Healthy Ageing” stand organised by the IHA, UCL for the Summer Science 2012 festival at the Royal Society, and at Bangkok Science and Technology Fair 2012, which is open to schools and the general public to inform people on how diet affects ageing and how can we study these effects using simple and tractable model organisms. More recently, he has participated and interviewed for a podcast for Radio Cardiff's science show, Pythagoras Trousers on the role of the microbiome in health.

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Cabreiro, F. (2016). Metformin Joins Forces with Microbes. CELL HOST & MICROBE, 19 (1), 1-3. doi:10.1016/j.chom.2015.12.012 de la Guardia, Y., Gilliat, A. F., Hellberg, J., Rennert, P., Cabreiro, F., & Gems, D. (2016). Run-on of germline apoptosis promotes gonad senescence in C. elegans. ONCOTARGET, 7 (26), 39082-39096. doi:10.18632/oncotarget.9681 Pryor, R, & Cabreiro, F. (2015). Repurposing Metformin – An old drug with new tricks in its binding pockets. Biochemical Journal, 471 (3), 307-322. doi:10.1042/BJ20150497 Coburn, C., Allman, E., Mahanti, P., Benedetto, A., gomes cabreiro, F., Pincus, Z., . . . Gems, D. H. (2013). Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans. PLoS Biology, 11 (7). doi:10.1371/journal.pbio.1001613 Leung, K. Y., De Castro, S. C., Cabreiro, F., Gustavsson, P., Copp, A. J., & Greene, N. D. (2013). Folate metabolite profiling of different cell types and embryos suggests variation in folate one-carbon metabolism, including developmental changes in human embryonic brain. Mol Cell Biochem, 378 (1-2), 229-236. doi:10.1007/s11010-013-1613-y Cabreiro, F., Au, C., Vergara-Irigaray, N., Cocheme, H. M., Noori, T., Weinkove, D., . . . Gems, D. (2013). Metformin retards aging in C.elegans by altering microbial folate and methionine metabolism. Cell, 153, 228-239. doi:10.1016/j.cell.2013.02.035 Cabreiro, F., & Gems, D. (2013). Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans. EMBO Mol Med, 5 (9), 1300-1310. doi:10.1002/emmm.201100972 Valentini, S., Cabreiro, F., Ackerman, D., Alam, M. M., Kunze, M. B., Kay, C. W., & Gems, D. (2012). Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans. Mech Ageing Dev, 133 (5), 282-290. doi:10.1016/j.mad.2012.03.003 Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári, M., Piper, M. D., . . . Gems, D. (2011). Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature, 477 (7365), 482-485. doi:10.1038/nature10296 Cabreiro, F., Ackerman, D., Doonan, R., Araiz, C., Back, P., Papp, D., . . . Gems, D. (2011). Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radic Biol Med, 51 (8), 1575-1582. doi:10.1016/j.freeradbiomed.2011.07.020 Cochemé, H. M., Quin, C., McQuaker, S. J., Cabreiro, F., Logan, A., Prime, T. A., . . . Murphy, M. P. (2011). Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab, 13 (3), 340-350. doi:10.1016/j.cmet.2011.02.003 Larbi, A., Cabreiro, F., Zelba, H., Marthandan, S., Combet, E., Friguet, B., . . . Pawelec, G. (2010). Reduced oxygen tension results in reduced human T cell proliferation and increased intracellular oxidative damage and susceptibility to apoptosis upon activation. Free Radic Biol Med, 48 (1), 26-34. doi:10.1016/j.freeradbiomed.2009.09.025 Cabreiro, F., & Gems, D. (2010). Treating aging: progress toward dietary restriction mimetics. F1000 Biol Rep, 2, 76-?. doi:10.3410/B2-76 Cabreiro, F., Picot, C. R., Perichon, M., Friguet, B., & Petropoulos, I. (2009). Overexpression of methionine sulfoxide reductases A and B2 protects MOLT-4 cells against zinc-induced oxidative stress. Antioxid Redox Signal, 11 (2), 215-225. doi:10.1089/ars.2008.2102 Cabreiro, F., Picot, C. R., Perichon, M., Friguet, B., & Petropoulos, I. (2008). Methionine sulfoxide reductases A and B2 protect MOLT-4 cells against H(2)O(2) and zinc-mediated cell death and protein damage. FREE RADICAL RESEARCH, 42, S91. INFORMA HEALTHCARE. Cabreiro, F., Picot, C. R., Perichon, M., Castel, J., Friguet, B., & Petropoulos, I. (2008). Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage. J Biol Chem, 283 (24), 16673-16681. doi:10.1074/jbc.M708580200 Cabreiro, F., Perichon, M., Jatje, J., Malavolta, M., Mocchegiani, E., Friguet, B., & Petropoulos, I. (2008). Zinc supplementation in the elderly subjects: effect on oxidized protein degradation and repair systems in peripheral blood lymphocytes. Exp Gerontol, 43 (5), 483-487. doi:10.1016/j.exger.2007.10.007 Cabreiro, F., Picot, C. R., Perichon, M., Mary, J., Friguet, B., & Petropoulos, I. (2007). Identification of proteins undergoing expression level modifications in WI-38 SV40 fibroblasts overexpressing methionine sulfoxide reductase A. Biochimie, 89 (11), 1388-1395. doi:10.1016/j.biochi.2007.05.005 Cabreiro, F., Picot, C. R., Friguet, B., & Petropoulos, I. (2006). Methionine sulfoxide reductases: relevance to aging and protection against oxidative stress. Ann N Y Acad Sci, 1067, 37-44. doi:10.1196/annals.1354.006