Bhakta, Sanjib - Birkbeck, University of London - Department of Biological Sciences

研究领域

Despite a concerted global effort to prevent the spread of Tuberculosis (TB), approximately 8.9 million new cases and 1.7 million deaths were reported in 2004. As many as 50 million people worldwide are currently infected with Multi Drug Resistant TB and 20 million people are predicted to die from TB before the end of this decade. Mycobacterium tuberculosis is a member of the order Actinomycetales and causes TB. The order Actinomycetales includes other pathogens, such as Mycobacterium leprae, Mycobacterium avium, Mycobacterium marinum and Mycobacterium bovis. These pathogens are major concerns in both human and animal (birds, fish, cattle) health. There are also many biotechnologically significant genera among the Actinomycetales involved in the production of antibiotics (Streptomyces, Actinomyces), production of amino acids (Corynebacterium glutamicum), used in the bioremediation of various petroleum products, di-n-butyl phthalate, benzene, toluene, m-xylene (BTX), their mixtures and styrene gas (Rhodococcus spp.), fixation of atmospheric nitrogen (Frankia spp.). A key common feature of these related genera are their complex cell walls, which consist of an unusual mycolyl-arabinogalactan-peptidoglycan complex. Research interests in my laboratory are focused on understanding the basic cell wall physiology of this group of microorganisms to aid further improvement towards biotechnological application, as well as evaluating therapeutic approaches either for prevention or combating diseases. Our research has been immensely facilitated by the availability of the complete genomic resources of many species within this group of bacteria causing diseases.

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Maitra, A., Kamil, T. K., Shaik, M., Danquah, C. A., Chrzastek, A., & Bhakta, S. (2016). Early diagnosis and effective treatment regimens are the keys to tackle antimicrobial resistance in tuberculosis (TB): a report from Euroscicon's international TB Summit 2016. Virulence 4:1-20. Kerai, L. V., Hilton, S., Maugueret, M., Kazi, B. B., Faull, J., Bhakta, S., & Murdan, S. (2016). UV-curable gels as topical nail medicines: In vivo residence, anti-fungal efficacy and influence of gel components on their properties. International Journal of Pharmaceutics, 514(1), 244-254. Phelan, J., Maitra, A., McNerney, R., Nair, M., Gupta, A., Coll, F., ... & Clark, T. G. (2015). The draft genome of Mycobacterium aurum, a potential model organism for investigating drugs against Mycobacterium tuberculosis and Mycobacterium leprae. International Journal of Mycobacteriology, 4(3), 207-216. Brucoli, F., Guzman, J. D., Basher, M. A., Evangelopoulos, D., McMahon, E., Munshi, T., ... & Bhakta, S. (2016). DNA sequence-selective C8-linked pyrrolobenzodiazepine–heterocyclic polyamide conjugates show anti-tubercular-specific activities. The Journal of antibiotics. Maitra, A., Bates, S., Shaik, M., Evangelopoulos, D., Abubakar, I., McHugh, T. D., ... & Bhakta, S. (2016). Repurposing drugs for treatment of tuberculosis: a role for non-steroidal anti-inflammatory drugs. British Medical Bulletin. Bhakta, S., Scalacci, N., Maitra, A., Brown, A. K., Dasugari, S., Evangelopoulos, D., ... & Manetti, F. (2016). Design and Synthesis of 1-((1, 5-Bis (4-chlorophenyl)-2-methyl-1 H-pyrrol-3-yl) methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N′-((E)-3, 7-dimethylocta-2, 6-dienyl) ethane-1, 2-diamine (SQ109) Pyrrole Hybrid Derivatives: Discovery of Potent Antitubercular Agents Effective against Multidrug-Resistant Mycobacteria. Journal of medicinal chemistry, 59(6), 2780-2793. Chandrashekhar Lele, A., Amarnath Mishra, D., Karmila Kamil, T., Bhakta, S., & Sohel Degani, M. (2016). Repositioning of DHFR Inhibitors. Current topics in medicinal chemistry, 16(19), 2125-2143. Danquah, C.A.; Maitra, A.; Gibbons, S.; Faull, J. and Bhakta, S.* (2015) HT-SPOTi: a rapid, gold standard drug susceptibility test (DST), to detect antibiotic resistance profile as well as to evaluate novel chemical entities for new anti-infective drug discovery. Current protocols in microbiology, 17-8. Lele, A.C.; Mishra, D.A.; Kamil, T.K.; Bhakta, S. and Degani, M.S. (2016) Repositioning of DHFR Inhibitors. Current Topics in Medicinal Chemistry. 16(19) 2125-2143. DOI: 10.2174/1568026616666160216152540 Hochfellner C, Evangelopoulos D, Zloh M, Wube A, Guzman JD, McHugh TD, Kunert O, Bhakta S, Bucar F (2015) Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine. J Appl Microbiol. 118(4):864-72. doi: 10.1111/jam.12753. Phelan, J.; Maitra, A.; McNerney, R.; Nair, M.; Gupta, A.; Coll, F.; Pain, A.; Bhakta, S. and Clark, T.G. (2015) The draft genome of Mycobacterium aurum, a potential model organism for investigating drugs against Mycobacterium tuberculosis and Mycobacterium leprae. Int.J. Mycobact. 4 (3) 207–216. doi:10.1016/j.ijmyco.2015.05.001 Rizi K, Murdan S, Danquah CA, Faull J. and Bhakta S.* (2015) Development of a rapid, reliable and quantitative method - "SPOTi" for testing antifungal efficacy. J Microbiol Methods. 117:36-40. doi:10.1016/j.mimet.2015.07.005 Quay DH, Cole AR, Cryar A, Thalassinos K, Williams MA, Bhakta S, Keep NH. (2015) Structure of the stationary phase survival protein YuiC from B. subtilis. BMC Struct Biol. 15:12. doi:10.1186/s12900-015-0039-z Maitra A, Danquah CA, Scotti F, Howard TK, Kamil TK, Bhakta S.* (2015) Tackling tuberculosis: Insights from an international TB Summit in London. Virulence 6(6):661-72. doi:10.1080/21505594.2015.1060396 Brucoli F, Guzman JD, Maitra A, James CH, Fox KR, Bhakta S. (2015) Synthesis, anti-mycobacterial activity and DNA sequence-selectivity of a library of biaryl-motifs containing polyamides. Bioorg Med Chem. 23(13):3705-11. doi:10.1016/j.bmc.2015.04.001 Maitra A, Bates S, Kolvekar T, Devarajan PV, Guzman JD, Bhakta S.* (2015) Repurposing-a ray of hope in tackling extensively drug resistance in tuberculosis. Int J Infect Dis. 32:50-5. doi:10.1016/j.ijid.2014.12.031 Guzman JD, Pesnot T, Barrera DA, Davies HM, McMahon E, Evangelopoulos D, Mortazavi PN, Munshi T, Maitra A, Lamming ED, Angell R, Gershater MC, Redmond JM, Needham D, Ward JM, Cuca LE, Hailes HC, Bhakta S.* (2015) Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase. J Antimicrob Chemother. 70(6):1691-703. doi:10.1093/jac/dkv010 Evangelopoulos, D., Gupta, A., Lack, N., Maitra, A., ten Bokum, A., Kendall, S., Sim, E. and Bhakta, S. (2014) Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis. Tuberculosis (Elsevier) 94(6):664-71. Abuhammad A, Fullam E, Bhakta S, Russell AJ, Morris GM, Finn PW and Sim E. (2014) Exploration of piperidinols as potential antitubercular agents. Molecules;19(10):16274-90. Maitra A and Bhakta S. (2014) TB Summit 2014: prevention, diagnosis, and treatment of tuberculosis – a meeting report of a Euroscicon conference. Virulence;5(5):638-44. Zhao J, Evangelopoulos D, Bhakta S, Gray AI and Seidel V. (2014) Antitubercular activity of Arctium lappa and Tussilago farfara extracts and constituents. J Ethnopharmacol.;155(1):796-800. McGuigan C, Derudas M, Gonczy B, Hinsinger K, Kandil S, Pertusati F, Serpi M, Snoeck R, Andrei G, Balzarini J, McHugh TD, Maitra A, Akorli E, Evangelopoulos D and Bhakta S. (2014) ProTides of N-(3-(5-(2'-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents. Bioorg Med Chem.;22(9):2816-24. Guzman, J.D.; Mortazavi, P.N.; Munshi, T.; Evangelopoulos, D.; McHugh, T.D.; Gibbons, S.; Malkinson, J. and Bhakta, S. (2014) 2-Hydroxy-substituted cinnamic acids and acetanilides are selective growth inhibitors of Mycobacterium tuberculosis. ChemMedComm 5 (1) 47 - 50. Shiu WK, Malkinson JP, Rahman MM, Curry J, Stapleton P, Gunaratnam M, Neidle S, Mushtaq S, Warner M, Livermore DM, Evangelopoulos D, Basavannacharya C, Bhakta, S., Schindler BD, Seo SM, Coleman D, Kaatz GW, Gibbons S. (2013) A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus. Int J Antimicrob Agents. 42(6):513-8. Maitra A, and Bhakta S. (2013) Mycobacterium tuberculosis... Can we beat it? Report from a Euroscicon conference 2013. Virulence;4(6):499-503.