个人简介

Stefan Howorka is Professor of Biological Chemistry. His group currently consists of 2 postdocs, 4 PhD students and 3 MRes students. Research in chemical biology within his group includes the biophysical analysis of protein pores of biomedical importance, the engineering of synthetic DNA nanopores for biosensing and synthetic biology, and the synthesis of nucleic acids probes for biological research. He was worked at UCL since 2005 (2003-9: Lecturer; 2009: Reader; 2016: Professor). Before this, he was a postdoctoral research associate at Texas A&M University, working with Professor Hagan Bayley.

研究领域

Organic Chemistry and Chemical Biology

Chemical biology Nanobiotechnology Nucleic acids chemistry Single-molecule biophysics

近期论文

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Burns, J. R., Seifert, A., Fertig, N., & Howorka, S. (2016). A biomimetic DNA-based channel for the ligand-controlled transport of charged molecular cargo across a biological membrane. NATURE NANOTECHNOLOGY, 11 (2), 152-156. doi:10.1038/NNANO.2015.279 Howorka, S., Messager, L., Burns, J. R., Kim, J., Cecchin, D., Hindley, J., . . . Battaglia, G. (2016). Biomimetic Hybrid Nanocontainers with Selective Permeability. Angewandte Chemie, 128 (37), 11272-11275. doi:10.1002/ange.201604677 Messager, L., Burns, J. R., Kim, J., Cecchin, D., Hindley, J., Pyne, A. L. B., . . . Howorka, S. (2016). Biomimetic Hybrid Nanocontainers with Selective Permeability. Angewandte Chemie International Edition, 55 (37), 11106-11109. doi:10.1002/anie.201604677 Howorka, S. (2016). Changing of the guard. SCIENCE, 352 (6288), 890-891. doi:10.1126/science.aaf5154 Hager, R., Burns, J. R., Grydlik, M. J., Halilovic, A., Haselgruebler, T., Schaeffler, F., & Howorka, S. (2016). Co-Immobilization of Proteins and DNA Origami Nanoplates to Produce High-Contrast Biomolecular Nanoarrays. SMALL, 12 (21), 2877-2884. doi:10.1002/smll.201600311 Howorka, S., & Siwy, Z. (2016). Nanopores and Nanochannels: From Gene Sequencing to Genome Mapping. ACS NANO, 10 (11), 9768-9771. doi:10.1021/acsnano.6b07041 Seifert, A., Göpfrich, K., Burns, J. R., Fertig, N., Keyser, U. F., & Howorka, S. (2015). Bilayer-spanning DNA nanopores with voltage-switching between open and closed state. ACS Nano, 9 (2), 1117-1126. doi:10.1021/nn5039433 Lukeman, P. S., & Howorka, S. (2015). Broadening students' minds. NATURE NANOTECHNOLOGY, 10 (11), 992. Ficici, E., Andricioaei, I., & Howorka, S. (2015). Dendrimers in Nanoscale Confinement: The Interplay between Conformational Change and Nanopore Entrance. NANO LETTERS, 15 (7), 4822-4828. doi:10.1021/acs.nanolett.5b01960 Maingi, V., Lelimousin, M., Howorka, S., & Sansom, M. S. P. (2015). Gating-like Motions and Wall Porosity in a DNA Nanopore Scaffold Revealed by Molecular Simulations. ACS NANO, 9 (11), 11209-11217. doi:10.1021/acsnano.5b06357 Ren, C. -. L., Schlapak, R., Hager, R., Szleifer, I., & Howorka, S. (2015). Molecular and Thermodynamic Factors Explain the Passivation Properties of Poly(ethylene glycol)-Coated Substrate Surfaces against Fluorophore-Labeled DNA Oligonucleotides. LANGMUIR, 31 (42), 11491-11501. doi:10.1021/acs.langmuir.5b02674 Kukwikila, M., & Howorka, S. (2015). Nanopore-Based Electrical and Label-Free Sensing of Enzyme Activity in Blood Serum. ANALYTICAL CHEMISTRY, 87 (18), 9149-9154. doi:10.1021/acs.analchem.5b01764 Buchsbaum, S. F., Nguyen, G., Howorka, S., & Siwy, Z. S. (2014). DNA-modified polymer pores allow pH- and voltage-gated control of channel flux. J Am Chem Soc, 136 (28), 9902-9905. doi:10.1021/ja505302q Burns, J. R., Al-Juffali, N., Janes, S. M., & Howorka, S. (2014). Membrane-spanning DNA nanopores with cytotoxic effect. Angew Chem Int Ed Engl, 53 (46), 12466-12470. doi:10.1002/anie.201405719 Howorka, S., & Hesse, J. (2014). Microarrays and single molecules: an exciting combination. SOFT MATTER, 10 (7), 931-941. doi:10.1039/c3sm52561a Goyal, P., Krasteva, P. V., Van Gerven, N., Gubellini, F., Van den Broeck, I., Troupiotis-Tsaïlaki, A., . . . Remaut, H. (2014). Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG. Nature, 516 (7530), 250-253. doi:10.1038/nature13768 Buchsbaum, S. F., Mitchell, N., Martin, H., Wiggin, M., Marziali, A., Coveney, P. V., . . . Howorka, S. (2013). Disentangling steric and electrostatic factors in nanoscale transport through confined space. Nano Lett, 13 (8), 3890-3896. doi:10.1021/nl401968r Howorka, S. (2013). DNA nanoarchitectonics: assembled DNA at interfaces. Langmuir, 29 (24), 7344-7353. doi:10.1021/la3045785 Burns, J. R., Göpfrich, K., Wood, J. W., Thacker, V. V., Stulz, E., Keyser, U. F., & Howorka, S. (2013). Lipid-Bilayer-Spanning DNA Nanopores with a Bifunctional Porphyrin Anchor. Angew. Chem. Int. Ed., n/a. doi:10.1002/anie.201305765 Burns, J. R., Stulz, E., & Howorka, S. (2013). Self-assembled DNA nanopores that span lipid bilayers. Nano Lett, 13 (6), 2351-2356. doi:10.1021/nl304147f Howorka, S., & Siwy, Z. S. (2012). Nanopores as protein sensors. Nat Biotechnol, 30 (6), 506-507. doi:10.1038/nbt.2264 Schlapak, R., Danzberger, J., Armitage, D., Morgan, D., Ebner, A., Hinterdorfer, P., . . . Howorka, S. (2012). Nanoscale DNA tetrahedra improve biomolecular recognition on patterned surfaces. Small, 8 (1), 89-97. doi:10.1002/smll.201101576 Schlapak, R., Danzberger, J., Haselgrübler, T., Hinterdorfer, P., Schäffler, F., & Howorka, S. (2012). Painting with biomolecules at the nanoscale: biofunctionalization with tunable surface densities. Nano Lett, 12 (4), 1983-1989. doi:10.1021/nl2045414 Baranova, E., Fronzes, R., Garcia-Pino, A., Van Gerven, N., Papapostolou, D., Péhau-Arnaudet, G., . . . Remaut, H. (2012). SbsB structure and lattice reconstruction unveil Ca2+ triggered S-layer assembly. Nature, 487 (7405), 119-122. doi:10.1038/nature11155 Nguyen, G., Howorka, S., & Siwy, Z. S. (2011). DNA strands attached inside single conical nanopores: ionic pore characteristics and insight into DNA biophysics. J MEMBR BIOL, 239 (1-2), 105-113. doi:10.1007/s00232-010-9328-4