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Genetic Complexity of Crohn's Disease in 2 Large Ashkenazi Jewish Families. Journal article; 2016; Gastroenterology Links: IRIS | UCL Discovery Authors: Levine AP,Pontikos N,Schiff ER,Jostins L,Speed D,Lovat LB,Barrett JC,Grasberger H,Plagnol V,Segal AW click to collapse Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity Journal article; 2015; PLOS ONE Links: IRIS | UCL Discovery | Author's | DOI Authors: Levine AP,Duchen MR,de Villiers S,Rich PR,Segal AW click to collapse Characterization of Expression Quantitative Trait Loci in the Human Colon Journal article; 2015; INFLAMMATORY BOWEL DISEASES Links: IRIS | UCL Discovery | Author's | DOI Authors: Singh T,Levine AP,Smith PJ,Smith AM,Segal AW,Barrett JC click to collapse Combinatorial Conflicting Homozygosity (CCH) analysis enables the rapid identification of shared genomic regions in the presence of multiple phenocopies Journal article; 2015; BMC GENOMICS Links: IRIS | UCL Discovery | Author's | DOI Authors: Levine AP,Connor TMF,Oygar DD,Neild GH,Segal AW,Maxwell PH,Gale DP click to collapse Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients Journal article; 2015; IMMUNOLOGY Links: IRIS | UCL Discovery | Author's | DOI Authors: Smith AM,Sewell GW,Levine AP,Chew TS,Dunne J,O'Shea NR,Smith PJ,Harrison PJ,Macdonald CM,Bloom SL,Segal AW click to collapse Exome Sequencing of 75 Individuals from Multiply Affected Coeliac Families and Large Scale Resequencing Follow Up Journal article; 2015; PLOS ONE Links: IRIS | UCL Discovery | Author's | DOI Authors: Mistry V,Bockett NA,Levine AP,Mirza MM,Hunt KA,Ciclitira PJ,Hummerich H,Neuhausen SL,Simpson MA,Plagnol V,van Heel DA click to collapse The genetics of inflammatory bowel disease in extended multiplex Ashkenazi Jewish kindreds Thesis/Dissertation; 2015; Links: IRIS | UCL Discovery Authors: Levine AP Mucosal Transcriptomics Implicates Under Expression of BRINP3 in the Pathogenesis of Ulcerative Colitis Journal article; 2014; INFLAMMATORY BOWEL DISEASES Links: IRIS | UCL Discovery | Author's | DOI Authors: Smith PJ,Levine AP,Dunne J,Guilhamon P,Turmaine M,Sewell GW,O'Shea NR,Vega R,Paterson JC,Oukrif D,Beck S,Bloom SL,Novelli M,Rodriguez-Justo M,Smith AM,Segal AW click to collapse The HVCN1 channel conducts protons across the phagocytic vacuole of neutrophils Journal article; 2014; EUROPEAN JOURNAL OF CLINICAL INVESTIGATION Links: IRIS | UCL Discovery | Author's Authors: Levine AP,Duchen MR,Segal AW click to collapse ZODET: software for the identification, analysis and visualisation of outlier genes in microarray expression data. Journal article; 2014; PLoS One Links: IRIS | UCL Discovery | Author's | DOI Authors: Roden DL,Sewell GW,Lobley A,Levine AP,Smith AM,Segal AW click to collapse Insights into TREM2 biology by network analysis of human brain gene expression data Journal article; 2013; Neurobiology of Aging Links: IRIS | UCL Discovery | DOI Authors: Forabosco P,Ramasamy A,Trabzuni D,Bras J,Hardy J,Guerreiro R,Ryten M,Weale ME,Walker R,Smith C,Levine AP,Pocock JM click to collapse Using Genetic Prediction from Known Complex Disease Loci to Guide the Design of Next-Generation Sequencing Experiments Journal article; 2013; PLOS ONE Links: IRIS | UCL Discovery | Author's | DOI Authors: Jostins L,Levine AP,Barrett JC click to collapse What is wrong with granulocytes in inflammatory bowel diseases? Journal article; 2013; Dig Dis Links: IRIS | UCL Discovery | Author's | DOI Authors: Levine AP,Segal AW click to collapse Defective tumor necrosis factor release from Crohn's disease macrophages in response to Toll-like receptor activation: relationship to phenotype and genome-wide association susceptibility loci. Journal article; 2012; Inflamm Bowel Dis Links: IRIS | UCL Discovery | Author's | DOI Authors: Sewell GW,Rahman FZ,Levine AP,Jostins L,Smith PJ,Walker AP,Bloom SL,Segal AW,Smith AM click to collapse MUCOSAL MRNA EXPRESSION PROFILING FROM THE TERMINAL ILEUM AND COLON REVEALS UNDER EXPRESSION OF CLAUDIN 8, A TIGHT JUNCTION MOLECULE, AS POTENTIALLY CAUSAL IN ULCERATIVE COLITIS Journal article; 2012; GUT Links: IRIS | UCL Discovery | Author's | DOI Authors: Smith PJ,Levine AP,Sewell GW,O'Shea NR,Vega R,Bloom SL,Smith AM,Segal AW click to collapse Endoscopy, but not as we know it Journal article; 2011; BRITISH JOURNAL OF HOSPITAL MEDICINE Links: IRIS | UCL Discovery | Author's Authors: Smith PJ,Sewell GW,Levine AP click to collapse Achieving vascular risk factor targets: A survey of a London general practice Journal article; 2008; ANGIOLOGY Links: IRIS | UCL Discovery | Author's | DOI Authors: Levine AP,Mikhailidis DP,Moross T,Benson K,Gor M click to collapse