个人简介

Helen Hailes is a Professor of Chemical Biology and has a strong record of interdisciplinary research and collaborations with industry. She has extensive expertise in sustainable synthesis for the preparation of chiral synthons using biocatalysts in single-step reactions, multi-step cascades and reactions in water. In addition, she investigates the synthesis of tools to identify, image or perturb biological targets and synthesise compounds with improved biological properties, particularly anti-bacterials. She also has experience in the design and synthesis of novel lipids and lipid-conjugates for multifunctional nanoparticle assembly to be used in therapeutic delivery and imaging. She currently leads a multidisciplinary research group of 5 PhD students and 4 post-doctoral researchers, together with several Masters students. She joined UCL in 1994 as a Lecturer, and in 2002 became a Senior Lecturer. In 2006 she became a Reader of Chemical Biology and in 2010 a Professor of Chemical Biology. Prior to joining UCL she carried out post-doctoral research at the University of Cambridge and Imperial College London.

研究领域

Organic Chemistry and Chemical Biology

Sustainable synthetic strategies and reactions in water Stereoselective synthesis using biocatalysts Enzymatic and chemoenzymatic multi-step reaction cascades Novel lipid synthesis and nanoparticles for delivery and imaging applications Tuberculosis chemotherapies

近期论文

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Weitsman, G., Mitchell, N. J., Evans, R., Cheung, A., Kalber, T. L., Bofinger, R., . . . Ng, T. (2017). Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor. Oncogene. doi:10.1038/onc.2016.522 Higson, S., Subrizi, F., Sheppard, T. D., & Hailes, H. C. (2016). Chemical cascades in water for the synthesis of functionalized aromatics from furfurals. GREEN CHEMISTRY, 18 (7), 1855-1858. doi:10.1039/c5gc02935j Kudsiova, L., Welser, K., Campbell, F., Mohammadi, A., Dawson, N., Cui, L., . . . Tabor, A. B. (2016). Delivery of siRNA using ternary complexes containing branched cationic peptides: the role of peptide sequence, branching and targeting. MOLECULAR BIOSYSTEMS, 12 (3), 934-951. doi:10.1039/c5mb00754b Jeffries, J. W. E., Dawson, N., Orengo, C., Moody, T. S., Quinn, D. J., Hailes, H. C., & Ward, J. M. (2016). Metagenome Mining: A Sequence Directed Strategy for the Retrieval of Enzymes for Biocatalysis. ChemistrySelect, 1 (10), 2217-2220. doi:10.1002/slct.201600515 McLaughlin, C., Assmann, M., Parkes, M. A., Woodhouse, J. L., Lewin, R., Hailes, H. C., . . . Fielding, H. H. (2016). ortho and para chromophores of green fluorescent protein: controlling electron emission and internal conversion. Chem. Sci.. doi:10.1039/C6SC03833F Hayes, T., Hu, Y., Sanchez-Vazquez, S. A., Hailes, H. C., Aliev, A. E., & Evans, J. R. G. (2016). Strategies for synthesis of epoxy resins from oleic acid derived from food wastes. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 54 (19), 3159-3170. doi:10.1002/pola.28203 Affaticati, P. E., Dai, S. -. B., Payongsri, P., Hailes, H. C., Tittmann, K., & Dalby, P. A. (2016). Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes. SCIENTIFIC REPORTS, 6, ARTN 35716. doi:10.1038/srep35716 Subrizi, F., Cardenas-Fernandez, M., Lye, G. J., Ward, J. M., Dalby, P. A., Sheppard, T. D., & Hailes, H. C. (2016). Transketolase catalysed upgrading of L-arabinose: the one-step stereoselective synthesis of L-gluco-heptulose. GREEN CHEMISTRY, 18 (10), 3158-3165. doi:10.1039/c5gc02660a Lichman, B. R., Gershater, M. C., Lamming, E. D., Pesnot, T., Sula, A., Keep, N. H., . . . Ward, J. M. (2015). 'Dopamine-first' mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile. FEBS JOURNAL, 282 (6), 1137-1151. doi:10.1111/febs.13208 Baud, D., Ladkau, N., Moody, T. S., Ward, J. M., & Hailes, H. C. (2015). A rapid, sensitive colorimetric assay for the high-throughput screening of transaminases in liquid or solid-phase. CHEMICAL COMMUNICATIONS, 51 (97), 17225-17228. doi:10.1039/c5cc06817g Rios-Solis, L., Morris, P., Grant, C., Odeleye, A. O. O., Hailes, H. C., Ward, J. M., . . . Lye, G. J. (2015). Modelling and optimisation of the one-pot, multi-enzymatic synthesis of chiral amino-alcohols based on microscale kinetic parameter determination. CHEMICAL ENGINEERING SCIENCE, 122, 360-372. doi:10.1016/j.ces.2014.09.046 Villegas-Torres, M. F., Martinez-Torres, R. J., Cazares-Koerner, A., Hailes, H., Baganz, F., & Ward, J. (2015). Multi-step biocatalytic strategies for chiral amino alcohol synthesis. ENZYME AND MICROBIAL TECHNOLOGY, 81, 23-30. doi:10.1016/j.enzmictec.2015.07.003 Richter, N., Simon, R. C., Lechner, H., Kroutil, W., Ward, J. M., & Hailes, H. C. (2015). omega-Transaminases for the amination of functionalised cyclic ketones. ORGANIC & BIOMOLECULAR CHEMISTRY, 13 (33), 8843-8851. doi:10.1039/c5ob01204j Lichman, B. R., Lamming, E. D., Pesnot, T., Smith, J. M., Hailes, H. C., & Ward, J. M. (2015). One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine. GREEN CHEMISTRY, 17 (2), 852-855. doi:10.1039/c4gc02325k Rowland, T., Hailes, H. C., & Evans, J. R. G. (2015). Sea salt as a potential ocean mirror material. RSC ADVANCES, 5 (49), 38926-38930. doi:10.1039/c5ra03469h Payongsri, P., Steadman, D., Hailes, H. C., & Dalby, P. A. (2015). Second generation engineering of transketolase for polar aromatic aldehyde substrates. ENZYME AND MICROBIAL TECHNOLOGY, 71, 45-52. doi:10.1016/j.enzmictec.2015.01.008 Deszcz, D., Affaticati, P., Ladkau, N., Gegel, A., Ward, J. M., Hailes, H. C., & Dalby, P. A. (2015). Single active-site mutants are sufficient to enhance serine:pyruvate -transaminase activity in an -transaminase. FEBS JOURNAL, 282 (13), 2512-2526. doi:10.1111/febs.13293 Foster, R. W., Tame, C. J., Bucar, D. -. K., Hailes, H. C., & Sheppard, T. D. (2015). Sustainable Synthesis of Chiral Tetrahydrofurans through the Selective Dehydration of Pentoses. CHEMISTRY-A EUROPEAN JOURNAL, 21 (45), 15947-15950. doi:10.1002/chem.201503510 Lamming, E. D. (2015). Synthesis of N-heterocycles as anti-asthma drugs and compounds with antimycobacterial properties (Doctoral dissertation). UCL (University College London). Guzman, J. D., Pesnot, T., Barrera, D. A., Davies, H. M., McMahon, E., Evangelopoulos, D., . . . Bhakta, S. (2015). Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 70 (6), 1691-1703. doi:10.1093/jac/dkv010 Mooney, C. R. S., Parkes, M. A., Zhang, L., Hailes, H. C., Simperler, A., Bearpark, M. J., & Fielding, H. H. (2014). Competition between photodetachment and autodetachment of the 21 ππ* state of the green fluorescent protein chromophore anion. Journal of Chemical Physics, 140 (20). doi:10.1063/1.4874643 Lamming, E. D., Hailes, H. C., Bhakta, S., Redmond, J. M., & Needham, D. (2014). Design, synthesis, and biological evaluation of alkaloids as potential antituberculosis drugs. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 247. AMER CHEMICAL SOC. Sehl, T., Hailes, H. C., Ward, J. M., Menyes, U., Pohl, M., & Rother, D. (2014). Efficient 2-step biocatalytic strategies for the synthesis of all nor(pseudo) ephedrine isomers. GREEN CHEMISTRY, 16 (6), 3341-3348. doi:10.1039/c4gc00100a Pennell, M. N., Foster, R. W., Turner, P. G., Hailes, H. C., Tame, C. J., & Sheppard, T. D. (2014). Gold catalysed synthesis of 3-alkoxyfurans at room temperature. Chem Commun (Camb), 50 (11), 1302-1304. doi:10.1039/c3cc48290a Aziz, A., Hailes, H. C., Ward, J. M., & Evans, J. R. G. (2014). Long-term stabilization of reflective foams in sea water. RSC Adv., 4 (95), 53028-53036. doi:10.1039/C4RA08714C