Ashcroft, Margaret - University College London

个人简介

I undertook my undergraduate (BSc Hons) and postgraduate (PhD) studies at the University of Bristol UK in Pharmacology and Molecular/Cellular Biology respectively, where I was awarded the first BRACE (Bristol Research into Alzheimer?s Disease and Care of the Elderly) PhD studentship. During my PhD, I worked on a novel family of tyrosine receptor kinases (TRKs) which we cloned and characterised in human brain. Upon obtaining my PhD, I moved to the United States to pursue my postdoctoral training at the National Cancer Institute (NCI-FCRDC, Frederick, Maryland). First, under the supervision of David Kaplan, I continued my to work on TRKs and made several key discoveries on the role of TRK-mediated survival via the PI3K signalling pathway. Subsequently, under the supervision of Karen Vousden, I worked on the tumour suppressor protein p53 and its regulator HDM2. In 2001, I moved back to the UK to set up my group as an independent PI at The Institute of Cancer Research (ICR) working on the hypoxia inducible factor (HIF) family of transcription factors, and the interplay between hypoxia signalling, p53 and HDM2. In 2008, I moved to University College London (UCL) and co-founded the Centre for Cell Signalling and Molecular Genetics (CSMG) within the Division of Medicine.

研究领域

My research programme primarily focuses on elucidating the key signalling mechanisms regulating the hypoxia inducible factor (HIF) pathway as a basis for gaining a better understanding of the role of HIF in disease (e.g. cancer, renal and cardiovascular diseases, and stroke) and translating our basic research findings by identifying novel therapeutics that target the HIF pathway.

近期论文

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Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20) Journal article; 2016; SCIENTIFIC REPORTS Links: IRIS | UCL Discovery | Author's | DOI Authors: Burrows N,Cane G,Robson M,Gaude E,Howat WJ,Szlosarek PW,Pedley RB,Frezza C,Ashcroft M,Maxwell PH click to collapse The synthesis and structure revision of NSC-134754 Journal article; 2014; CHEMICAL COMMUNICATIONS Links: IRIS | UCL Discovery | Author's | DOI Authors: Hickin JA,Ahmed A,Fucke K,Ashcroft M,Jones K click to collapse Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination. Journal article; 2013; Circ Res Links: IRIS | UCL Discovery | Author's | DOI Authors: Luong LEA,Fragiadaki M,Smith J,Boyle J,Lutz J,Dean JL,Harten S,Ashcroft M,Walmsley SR,Haskard DO,Maxwell PH,Walczak H,Pusey C,Evans PC click to collapse Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination. Journal(Full / Special issue); 2013; Circulation Research Links: IRIS | UCL Discovery | DOI Authors: Luong LA,Fragiadaki M,Smith J,Boyle J,Lutz J,Dean JL,Harten S,Ashcroft M,Walmsley SR,Haskard DO,Maxwell PH,Walczak H,Pusey C,Evans PC click to collapse Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways Journal article; 2013; CELL DEATH & DISEASE Links: IRIS | UCL Discovery | Author's | DOI Authors: Selvarajah J,Nathawat K,Moumen A,Ashcroft M,Carroll VA click to collapse Evaluation and immunohistochemical qualification of carbogen-induced ?R? as a noninvasive imaging biomarker of improved tumor oxygenation. Journal article; 2013; Int J Radiat Oncol Biol Phys Links: IRIS | UCL Discovery | Author's | DOI Authors: Baker LC,Boult JK,Jamin Y,Gilmour LD,Walker-Samuel S,Burrell JS,Ashcroft M,Howe FA,Griffiths JR,Raleigh JA,van der Kogel AJ,Robinson SP click to collapse A dual role for hypoxia inducible factor-1 alpha in the hepatitis C virus lifecycle and hepatoma migration Journal article; 2012; JOURNAL OF HEPATOLOGY Links: IRIS | UCL Discovery | Author's Authors: Wilson GK,Brimacombe CL,Rowe IA,Reynolds GM,Fletcher NF,Stamataki Z,Bhogal RH,Simoes ML,Ashcroft M,Afford SC,Mitry RR,Dhawan A,Mee CJ,Huebscher SG,Balfe P,McKeating JA click to collapse Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression. Journal article; 2012; J Clin Invest Links: IRIS | UCL Discovery | Author's | DOI Authors: Yang J,Staples O,Thomas LW,Briston T,Robson M,Poon E,Simões ML,El-Emir E,Buffa FM,Ahmed A,Annear NP,Shukla D,Pedley BR,Maxwell PH,Harris AL,Ashcroft M click to collapse The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function. Journal article; 2012; Br J Cancer Links: IRIS | UCL Discovery | Author's | DOI Authors: Baker LC,Boult JK,Walker-Samuel S,Chung YL,Jamin Y,Ashcroft M,Robinson SP click to collapse Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1?-mediated apoptosis. Journal article; 2011; Br J Cancer Links: IRIS | UCL Discovery | Author's | DOI Authors: Khan MN,Bhattacharyya T,Andrikopoulos P,Esteban MA,Barod R,Connor T,Ashcroft M,Maxwell PH,Kiriakidis S click to collapse HIF-1? localization with mitochondria: a new role for an old favorite? Journal article; 2011; Cell Cycle Links: IRIS | UCL Discovery | Author's | DOI Authors: Briston T,Yang J,Ashcroft M click to collapse Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells. Journal article; 2011; Mol Cancer Links: IRIS | UCL Discovery | Author's | DOI Authors: Harten SK,Esteban MA,Shukla D,Ashcroft M,Maxwell PH click to collapse Pharmacological activation of a novel p53-dependent S-phase checkpoint involving CHK-1. Journal article; 2011; Cell Death Dis Links: IRIS | UCL Discovery | Author's | DOI Authors: Ahmed A,Yang J,Maya-Mendoza A,Jackson DA,Ashcroft M click to collapse Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection. Journal article; 2010; Antioxid Redox Signal Links: IRIS | UCL Discovery | Author's | DOI Authors: Harten SK,Ashcroft M,Maxwell PH click to collapse TRP-ing off the p53 apoptotic switch. Journal article; 2010; Pigment Cell and Melanoma Research Links: IRIS | UCL Discovery | DOI | Publisher Authors: Ahmed A,Ashcroft M click to collapse Activation of a unique p53-dependent DNA damage response. Journal article; 2009; Cell Cycle Links: IRIS | UCL Discovery | Author's Authors: Yang J,Ahmed A,Ashcroft M click to collapse An MRI and histological investigation of the acute response of orthotopic PC3 prostate tumours to the HIF pathway inhibitor NSC-134754 in vivo Conference ; Molecular Cancer Therapeutics Links: IRIS | UCL Discovery Authors: Baker L,Boult J,Walker-Samuel S,Jamin Y,Ashcroft M,Robinson S click to collapse Angiogenic Cancer Therapy Journal article; 2009; Brit J Cancer Links: IRIS | UCL Discovery Authors: Maxwell PH,Ashcroft M click to collapse Diminished macrophage apoptosis and reactive oxygen species generation after phorbol ester stimulation in Crohn's disease. Journal article; 2009; PLoS One Links: IRIS | UCL Discovery | Author's | DOI Authors: Palmer CD,Rahman FZ,Sewell GW,Ahmed A,Ashcroft M,Bloom SL,Segal AW,Smith AM click to collapse Diminished Macrophage Apoptosis and Reactive Oxygen Species Generation after Phorbol Ester Stimulation in Crohn?s Disease Journal article; 2009; PLoS One Links: IRIS Authors: Palmer CD,Rahman FZ,Sewell GW,Ahmed A,Ashcroft M,Bloom SL,Segal AW,Smith AM click to collapse Prolyl hydroxyase inhibitors: a route to HIF activation and neuroprotection. Journal article; 2009; Antioxidants and Redox Signaling Links: IRIS | UCL Discovery Authors: Harten S,Ashcroft M,Maxwell PH click to collapse PTEN CAN FUNCTION AS A TUMOUR SUPPRESSOR IN CLEAR CELL RENAL CARCINOMA Journal article; 2009; EUROPEAN UROLOGY SUPPLEMENTS Links: IRIS | UCL Discovery | Author's Authors: Barod R,Domin J,Eccles S,O' Brien TS,Ashcroft M,Maxwell PH click to collapse PTEN can function as a tumour suppressor in clear cell renal carcinoma Conference ; 2009; BJU INTERNATIONAL Links: IRIS | UCL Discovery | Author's Authors: Barod R,Domin J,Eccles S,Ashcroft M,O'Brien TS,Maxwell PH click to collapse Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to follicle-stimulating hormone Journal article; 2009; Endocrinology Links: IRIS | UCL Discovery Authors: Alam H,Weck J,Maizels E,Park Y,Lee EJ,Ashcroft M,Hunzicher-Dunn M click to collapse Small molecule activation of p53 blocks HIF-1? and VEGF 1 expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia Journal article; 2009; Molecular and Cellular Biology Links: IRIS | Author's Authors: Yang J,Ahmed A,Poon E,Perusinghe N,de HBA,Box G,Valenti M,Eccles S,Rouschop K,Wouters B,Ashcroft M click to collapse