Chudasama, Vijay - University College London

个人简介

Dr Vijay Chudasama graduated from University College London (UCL), 2008, where he worked on a novel, versatile approach for the synthesis of 2,4-substituted oxazoles under the tutelage of Dr. Jon Wilden. He received a number of awards/scholarships, including Science, Engineering and Technology (SET) Chemistry Student of the Year (2008) , Bader Prize (2008), Faculty of Mathematical and Physical Sciences Medal and Prize (2008), Tufnell Scholarship (2008), Dean’s list (2008), Franz Sondheimer Prize (2007), Charles Vernon Prize (2007), Jackson-Lewis Scholarship (2006), Christopher-Ingold Scholarship (2005, 2006, 2007) and AstraZeneca Chemistry Bursary (2004, 2005, 2006, 2007). Following his undergraduate studies, Dr Chudasama obtained his PhD (2011) at UCL working with both Prof. Stephen Caddick and Dr Richard Fitzmaurice on the use of aerobic aldehyde C-H activation for the construction of C-C and C-N bonds. He won a collection of awards/prizes: Ramsay Medal (2011), 1st Prize at Final Year Organic Chemistry and Chemical Biology PhD Presentation Competition (2011), Lilly Postgraduate Prize Day (2010), 1st Prize at UCL Chemistry Postgraduate Poster Competition (2010) and UCL Graduate School Research Scholarship (2008, 2009, 2010). After his graduate work, Dr Chudasama took a year out to work in patent law, before returning to UCL to do a postdoctoral stay in the laboratories of Prof. Stephen Caddick and Dr Mark Smith where he turned his attention to developing novel reagents for cysteine and disulfide functionalisation. In 2013, he was highlighted by Scientific American to be one of 30 scientists, under 30 years old, across the world with promising prospects in Chemistry and selected to attend the 63rd Lindau Nobel Laurette Meeting. In 2014, Dr Chudasama was awarded a prestigious Ramsay Fellowship in the field of Chemical Biology and was made Technical Director of biologicals company (ThioLogics), which is based on technology he is a co-inventor of (www.thiologics.com). In early 2015, Dr Chudasama was appointed to a lectureship at UCL following his being highlighted as a future leader in Science by Forbes magazine and the Royal Society of Chemistry. In late 2015, Dr Chudasama was awarded a UCL Excellence Fellowship and, in early 2016, was highlighted by CNN news for his research on antibody-drug conjugates. His group is multidisciplinary and currently consists of 5 postdocs, 3 PhD students and 2 MRes students.

研究领域

Organic Synthesis and Chemical Biology Protein Modification, Bioconjugation, Antibody Functionalisation Optogenetic Tools Photodynamic Therapy Click Chemistry Small Molecule Drug Conjugates Aerobic C-H Activation Polymersomes Au nanoparticles Folic acid conjugates

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Robinson, E., Nunes, J. P. M., Vassileva, V., Maruani, A., Nogueira, J. C. F., Smith, M. E. B., . . . Chudasama, V. (2017). Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody. RSC Advances, 7 (15), 9073-9077. doi:10.1039/C7RA00788D Maruani, A., Lee, M. T. W., Watkins, G., Akhbar, A. R., Baggs, H., Shamsabadi, A., . . . Chudasama, V. (2016). A facile, one-pot procedure for the conversion of aromatic aldehydes to esters, as well as thioesters and amides, via acyl hydrazide intermediates. RSC ADVANCES, 6 (4), 3372-3376. doi:10.1039/c5ra26842g Pye, H., Butt, A., Reinert, H., Maruani, A., Nunes, J., Marklew, J. S., . . . Lovat, L. (2016). A HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy. PHOTOCHEMICAL AND PHOTOBIOLOGICAL SCIENCES. doi:10.1039/c6pp00139d Shamsabadi, A., & Chudasama, V. (2016). An overview of the synthesis of acyl hydrazides from aldehydes and reactions of the products thereof. Org Biomol Chem. doi:10.1039/c6ob02099b RICHARDS, D. A., MARUANI, A., & Chudasama, V. (2016). Antibody fragments as nanoparticle targeting ligands: a step in the right direction. CHEMICAL SCIENCE. doi:10.1039/C6SC02403C Maruani, A., Richards, D. A., & Chudasama, V. (2016). Dual modification of biomolecules. ORGANIC & BIOMOLECULAR CHEMISTRY, 14 (26), 6165-6178. doi:10.1039/c6ob01010e Robinson, E., Knight, E., Smoktunowicz, N., Chambers, R. C., Inglis, G. G., Chudasama, V., & Caddick, S. (2016). Identification of an active metabolite of PAR-1 antagonist RWJ-58259 and synthesis of analogues to enhance its metabolic stability. ORGANIC & BIOMOLECULAR CHEMISTRY, 14 (12), 3198-3201. doi:10.1039/c6ob00332j Lee, M. T. W., Maruani, A., Baker, J. R., Caddick, S., & Chudasama, V. (2016). Next-generation disulfide stapling: reduction and functional re-bridging all in one. CHEMICAL SCIENCE, 7 (1), 799-802. doi:10.1039/c5sc02666k Chudasama, V., Maruani, A., & Caddick, S. (2016). Recent advances in the construction of antibody-drug conjugates. NATURE CHEMISTRY, 8 (2), 113-118. doi:10.1038/NCHEM.2415 Gaitzsch, J., Chudasama, V., Morecroft, E., Messager, L., & Battaglia, G. (2016). Synthesis of an Amphiphilic Miktoarm Star Terpolymer for Self-Assembly into Patchy Polymersomes. ACS MACRO LETTERS, 5 (3), 351-354. doi:10.1021/acsmacrolett.5b00913 Knight, E., Robinson, E., Smoktunowicz, N., Chambers, R. C., Aliev, A. E., Inglis, G. G., . . . Caddick, S. (2016). Synthesis of novel and potent vorapaxar analogues. ORGANIC & BIOMOLECULAR CHEMISTRY, 14 (12), 3264-3274. doi:10.1039/c5ob02541a Smoktunowicz, N., Platé, M., Stern, A. O., D'Antongiovanni, V., Robinson, E., Chudasama, V., . . . Chambers, R. C. (2016). TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells. Oncotarget. Lee, M. T. W., Maruani, A., & Chudasama, V. (2016). The use of 3,6-pyridazinediones in organic synthesis and chemical biology. JOURNAL OF CHEMICAL RESEARCH (1), 1-9. doi:10.3184/174751916X14495034614855 Morgan, R. E., Chudasama, V., Moody, P., Smith, M. E. B., & Caddick, S. (2015). A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation. ORGANIC & BIOMOLECULAR CHEMISTRY. doi:10.1039/c5ob00130g Smith, M. E. B., Caspersen, M. B., Robinson, E., Morais, M., Maruani, A., Nunes, J. P. M., . . . Chudasama, V. (2015). A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine. ORGANIC & BIOMOLECULAR CHEMISTRY, 13 (29), 7946-7949. doi:10.1039/c5ob01205h Maruani, A., Smith, M. E. B., Miranda, E., Chester, K. A., Chudasama, V., & Caddick, S. (2015). A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy. NATURE COMMUNICATIONS, 6, ARTN 6645. doi:10.1038/ncomms7645 Nunes, J. P. M., Morais, M., Vassileva, V., Robinson, E., Rajkumar, V. S., Smith, M. E. B., . . . Chudasama, V. (2015). Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC). CHEMICAL COMMUNICATIONS, 51 (53), 10624-10627. doi:10.1039/c5cc03557k Chudasama, V. (2015). Pentafluorophenyl vinyl sulfonate enables efficient, metal-free, radical-based alkene hydroacylation with an aldehyde as a limiting reagent. RSC ADVANCES, 5 (55), 44423-44426. doi:10.1039/c5ra08353b Richards, D. A., Fletcher, S. A., Nobles, M., Kossen, H., Tedaldi, L., Chudasama, V., . . . Baker, J. R. (2015). Photochemically re-bridging disulfide bonds and the discovery of a thiomaleimide mediated photodecarboxylation of C-terminal cysteines. ORGANIC & BIOMOLECULAR CHEMISTRY, 14 (2), 455-459. doi:10.1039/c5ob02120k Maruani, A., Savoie, H., Bryden, F., Caddick, S., Boyle, R., & Chudasama, V. (2015). Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic. CHEMICAL COMMUNICATIONS, 51 (83), 15304-15307. doi:10.1039/c5cc06985h Maruani, A., Alom, S., Canavelli, P., Lee, M. T. W., Morgan, R. E., Chudasama, V., & Caddick, S. (2014). A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates. CHEMICAL COMMUNICATIONS, 51 (25), 5279-5282. doi:10.1039/c4cc08515a Moody, P., Chudasama, V., Nathani, R. I., Maruani, A., Martin, S., Smith, M. E. B., & Caddick, S. (2014). A rapid, site-selective and efficient route to the dual modification of DARPins. CHEMICAL COMMUNICATIONS, 50 (38), 4898-4900. doi:10.1039/c4cc00053f Akhbar, A. R., Chudasama, V., Fitzmaurice, R. J., Powell, L., & Caddick, S. (2014). Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones. CHEMICAL COMMUNICATIONS, 50 (6), 743-746. doi:10.1039/c3cc47967f Schumacher, F. F., Nunes, J. P. M., Maruani, A., Chudasama, V., Smith, M. E. B., Chester, K. A., . . . Caddick, S. (2014). Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging. ORGANIC & BIOMOLECULAR CHEMISTRY, 12 (37), 7261-7269. doi:10.1039/c4ob01550a Browne, L. E., Nunes, J. P. M., Sim, J. A., Chudasama, V., Bragg, L., Caddick, S., & North, R. A. (2014). Optical control of trimeric P2X receptors and acid-sensing ion channels. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111 (1), 521-526. doi:10.1073/pnas.1318582111