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Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca 2+ -dependent mitochondrial dysfunction and acute pancreatitis Journal article ; 2014 ; Gut links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Huang W,Booth DM,Cane MC,Chvanov M,Javed MA,Elliott VL,Armstrong JA,Dingsdale H,Cash N,Li Y,Greenhalf W,Mukherjee R,Kaphalia BS,Jaffar M,Petersen OH,Tepikin AV,Sutton R,Criddle DN
Potential Tumor-Selective Nitroimidazolylmethyluracil Prodrug Derivatives: Inhibitors of the Angiogenic Enzyme Thymidine Phosphorylase Journal article ; 2003 ; Journal of Medicinal Chemistry links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Cole C,Reigan P,Gbaj A,Edwards PN,Douglas KT,Stratford IJ,Freeman S,Jaffar M
Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1 targeted tripartite quinone drug delivery system Journal article ; 2007 ; Molecular Cancer Therapeutics links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Volpato M,Abou-Zeid N,Tanner RW,Glassbrook LT,Taylor J,Stratford I,Loadman PM,Jaffar M,Phillips RM
Menadione-induced Reactive Oxygen Species Generation via Redox Cycling Promotes Apoptosis of Murine Pancreatic Acinar Cells Journal article ; 2006 ; Journal of Biological Chemistry links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Criddle DN,Gillies S,Baumgartner-Wilson HK,Jaffar M,Chinje EC,Passmore S,Chvanov M,Barrow S,Gerasimenko OV,Tepikin AV,Sutton R,Petersen OH
A novel design strategy for stable metal complexes of nitrogen mustards as bioreductive prodrugs Journal article ; 2004 ; Journal of Medicinal Chemistry links: IRIS ; UCL Discovery authors [click to collapse] : Parker LL,Lacy SM,Farrugia LJ,Evans C,Robins DJ,O'Hare CC,Hartley JA,Jaffar M,Stratford IJ
Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours Journal article ; 2002 ; GENE THERAPY ; NATURE PUBLISHING GROUP links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Patterson AV,Williams KJ,Cowen RL,Jaffar M,Telfer BA,Saunders M,Airley R,Honess D,Van der Kogel AJ,Wolf CR,Stratford IJ
Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs Journal article ; 2004 ; Biochemical Pharmacology links: IRIS ; doi authors [click to collapse] : Phillips RM,Jaffar M,Maitland DJ,Loadman PM,Shnyder SD,Steans G,Cooper PA,Race A,Patterson AV,Stratford IJ
Synthesis and enzymatic evaluation of pyridinium-Substituted uracil derivatives as novel inhibitors of thymidine phosphorylase Journal article ; 2002 ; Bioorganic & Medicinal Chemistry links: IRIS ; doi authors [click to collapse] : Murray PE,McNally VA,Lockyer SD,Williams KJ,Stratford IJ,Jaffar M,Freeman S
Abstract 550: Evaluation of NQO1 as a potential diagnostic marker for bladder cancer Conference presentation ; 2015 links: IRIS ; doi authors [click to collapse] : Cuff S,Lewis R,Jaffar M,Knox R,Weeks I
435 POSTER Modulation of the activity of tumour associated carbonic anhydrases for therapeutic benefit Conference presentation ; 2006 links: IRIS ; doi authors [click to collapse] : Glassbrook L,Wang R,Williams K,Jaffar M,Stratford IJ
168 POSTER Design, synthesis and evaluation of novel, selective carbonic anhydrase IX inhibitors as anti-cancer agents Conference presentation ; 2006 links: IRIS ; doi authors [click to collapse] : Wang R,Glassbrook L,Bryce R,Stratford I,Supuran C,Jaffar M
500 Bioreductive activation and in vitro cytotoxicity of MUP03/704: a novel bioreductive cytotoxic drug conjugate for solid tumours Conference presentation ; 2004 links: IRIS ; doi authors [click to collapse] : Volpato M,Loadman PM,Zeid NA,Jaffar M,Stratford IJ,Phillips RM
499 N(O)-(Substituted)-b-(2),4,5-tetramethyl-3,6-dioxo-1,4-cyclo-hexadinen-1-propa(noate) propanoamide: bioreductive delivery systems for selective delivery of therapeutic agents into solid tumours Conference presentation ; 2004 links: IRIS ; doi authors [click to collapse] : Tanner R,Abou-Zeid N,Glassbrook LT,Phillips RM,Stratford IJ,Jaffar M
A novel human P450 reductase activated indolequinone prodrug for use in adenoviral mediated hypoxia selective gene therapy Conference presentation ; 2002 links: IRIS ; doi authors [click to collapse] : Cowen R,Williams KJ,Jaffar M,Telfer B,Garvey D,Stratford IJ
In silico and flexible docking screening using bioavailability, similarity and energetic filters: application to human thymidine phosphorylase Conference presentation ; 2002 links: IRIS ; doi authors [click to collapse] : McNally V,Jaffar M,Freeman S,Stratford IJ,Bryce R
Cytotoxic indolequinones as NQO1-directed tumour-specific bioreductive prodrugs Conference presentation ; 2002 links: IRIS ; doi authors [click to collapse] : Mrema I,Williams KJ,Wind S,Patterson AV,Phillips RM,Stratford IJ,Jaffar M
The synthesis of hypoxia-selective nitroaromatic compounds as bioreductive drug delivery agents Conference presentation ; 2002 links: IRIS ; doi authors [click to collapse] : Nakamya A,Stratford IJ,Freeman S,Jaffar M
Indolequinone carbamate prodrugs of mustards as hypoxia-selective cytotoxins Conference presentation ; 2002 links: IRIS ; doi authors [click to collapse] : Robinson I,Jaffar M,Wind NS,Williams KJ,Stratford IJ
Novel nitroimidazoyluracil prodrug derivatives as tumour-selective inhibitors of the angiogenic enzyme thymidine phosphorylase Conference presentation ; 2002 links: IRIS ; doi authors [click to collapse] : Jaffar M,Cole C,Gbaj A,Reigan P,Edwards P,Freeman S,Stratfrod IJ
Characterisation of CA-IX expression and activity in human tumour cell lines Conference presentation ; 2002 links: IRIS ; doi authors [click to collapse] : Parker C,Jaffar M,Williams KJ,Robertson N,Harris AL,Stratford IJ
Bioreductive Conjugates for Drug Targeting Patent ; 1998 ; US links: IRIS ; UCL Discovery authors [click to collapse] : Blake D,Naughton D,Adams G,Stratford I,Morris C,Jaffar M,Naylor M
Drug Targeting Patent ; 1999 ; US links: IRIS ; UCL Discovery authors [click to collapse] : Freeman S,Jaffar M,Stratford I
Methods and Compounds for Detecting Cancer Patent ; 2014 ; US links: IRIS ; UCL Discovery authors [click to collapse] : Weeks I,Jaffar M,Knox RJ
The Synthesis of cis‐and trans‐1, 3‐Dimethyl‐4‐Diphenylmethoxypiperidines as Conformationally Restricted Analogues of Diphenylpyraline Journal article ; 1996 ; Pharmacy and Pharmacology Communications ; Royal Pharmaceutical Society of Great Britain links: IRIS ; UCL Discovery authors : Upton C,Jaffar M
5-Substituted analogues of 3-hydroxymethyl-5-aziridinyl-1-methyl-2-[1H-indole-4, 7-dione [prop-2-en-1-ol (EO9, NSC 282459) and their regioisomers as hypoxia-selective agents: structure-cytotoxicity in vitro Journal article ; 1998 ; Anti-cancer Drug Design links: IRIS ; UCL Discovery authors [click to collapse] : Jaffar M,Naylor MA,Robertson N,Lockyer SD,Phillips RM,Everett SA,Adams GE,Stratford IJ
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