Wells, Geoffrey - University College London

个人简介

BPharm Hons (Pharmacy), 1st, University of Nottingham, 1993 PhD in Medicinal Chemistry, University of Nottingham, 1998

研究领域

Medicinal chemistry of anticancer and cancer chemopreventive agents Targeting the transcription factor Nrf2 for the treatment of diseases The role of reversible Michael acceptor molecules in drug discovery

近期论文

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PMI: A ΔΨm independent pharmacological regulator of mitophagy Journal article ; 2014 ; Chemistry and Biology links: IRIS ; UCL Discovery ; doi authors [click to collapse] : East DA,Fagiani F,Crosby J,Georgakopoulos ND,Bertrand H,Schaap M,Fowkes A,Wells G,Campanella M 3-(2-Oxoethylidene)indolin-2-one Derivatives Activate Nrf2 and Inhibit NF-kappa B: Potential Candidates for Chemoprevention Journal article ; 2014 ; CHEMMEDCHEM links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Nagle AA,Reddy SA,Bertrand H,Tajima H,Dang T-M,Wong S-C,Hayes JD,Wells G,Chew E-H Design, synthesis and biological evaluation of peptide inhibitors of the Keap1-Nrf2 protein-protein interaction Conference ; 2011 ; AACR Meeting Abstracts links: IRIS ; UCL Discovery authors [click to collapse] : Hancock R,Bertrand H,Naz S,Tsujita T,Hayes J,Wells G Design, synthesis and biological evaluation of AT sequence-selective DNA minor-groove binding analogues of distamycin Conference ; 2009 ; AACR Meeting Abstracts links: IRIS ; UCL Discovery authors [click to collapse] : Brucoli F,Basu P,Howard P,Wells G,Hartley J,Fox K,Thurston D Design, synthesis and biological evaluation of novel DNA minor-groove binding molecules containing a biaryl motif Conference ; 2008 ; AACR Meeting Abstracts links: IRIS ; UCL Discovery authors [click to collapse] : Rahman K,Basu P,Wells G,Howard P,Hartley J,Thurston D Thiol-interactive antitumor quinols as modulators of cellular redox homeostasis Conference ; 2005 ; Clinical Cancer Research links: IRIS ; UCL Discovery authors [click to collapse] : Westwell A,Chew E-H,Zhang J,Matthews C,Hagen T,Bradshaw T,McCarroll A,Wells G,Stevens M Differential cellular localisation and in vitro cytotoxicity of two novel fluorescent pyrrolobenzodiazepine (PBD) conjugate molecules Conference ; 2005 ; AACR Meeting Abstracts links: IRIS ; UCL Discovery authors [click to collapse] : Suggitt M,Stephenson M,Wells G,Baig M,Loadman P,Hartley J,Thurston D Pyrrolobenzodiazepine-polyamide libraries: Synthesis and DNA binding selectivity Conference ; 2003 ; Journal of Pharmacy and Pharmacology links: IRIS ; UCL Discovery authors [click to collapse] : Wells G,Gale T,Hardy A,Hamaguchi A,Hartley J,Wilkinson G,Loadman P,Jenkins T,Howard P,Thurston D Novel lead antitumour structures from oxygenated and hydroxylated bicyclic heterocycles Conference ; 2002 ; British Journal of Cancer links: IRIS ; UCL Discovery authors [click to collapse] : Wells G,Berry J,Bradshaw T,Burger A,Matthews C,Stevens M,Westwell A,Vasselin D Synthesis of heteroaromatic quinols, novel agents with selective activity clustered in colon and renal cell lines Conference ; 2002 ; Proceedings of the American Association for Cancer Research Annual Meeting links: IRIS ; UCL Discovery authors [click to collapse] : Westwell A,Wells G,Berry J,Bradshaw T,Burger A,Matthews C,Stevens M The use of the COMPARE algorithm to guide mechanistic studies on novel antitumor agents: A tale of two benzothiazoles Conference ; 2002 ; Proceedings of the American Association for Cancer Research Annual Meeting links: IRIS ; UCL Discovery authors [click to collapse] : Stevens M,Wells G,Bradshaw T,Westwell A,Holbeck S Routes to structural diversity and novel antitumour compounds from the hypervalent iodine oxidation of bioactive phenols Conference ; 2000 ; Clinical Cancer Research links: IRIS ; UCL Discovery authors [click to collapse] : Wells G,Seaton A,Westwell A,Bradshaw T,Stevens M Structure and activity of oxidised phenolic tyrosine kinase inhibitors Conference ; 1998 ; Annals of Oncology links: IRIS ; UCL Discovery authors [click to collapse] : Seaton A,Wells G,Stevens M Novel prodrugs Patent ; 2010 links: IRIS ; UCL Discovery authors [click to collapse] : Wells G,McCarroll A,Stevens M Biomedical applications of fluorinated amino acids and peptides Chapter ; 2015 ; Fluorinated pharmaceuticals: advances in medicinal chemistry ; Future Science links: IRIS ; UCL Discovery ; doi ; publisher authors : Fowkes A,Wells G Biochemical assays and biophysical tools for inhibitor identification and validation Chapter ; 2013 ; Understanding and exploiting protein—protein interactions as drug targets ; Future Science links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Fowkes A,Bertrand H,Wells G Development of a steady-state FRET-based assay to identify inhibitors of the Keap1-Nrf2 protein-protein interaction Journal article ; 2013 ; Protein Science links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Schaap M,Hancock R,Wilderspin A,Wells G An extended pyrrolobenzodiazepine-polyamide conjugate with selectivity for a DNA sequence containing the ICB2 transcription factor binding site. Journal article ; 2013 ; J Med Chem ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Brucoli F,Hawkins RM,James CH,Jackson PJ,Wells G,Jenkins TC,Ellis T,Kotecha M,Hochhauser D,Hartley JA,Howard PW,Thurston DE Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction with improved binding and cellular activity. Journal article ; 2013 ; Org Biomol Chem ; England links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Hancock R,Schaap M,Pfister H,Wells G Induction of Tumor Cell Death through Targeting Tubulin and Evoking Dysregulation of Cell Cycle Regulatory Proteins by Multifunctional Cinnamaldehydes Journal article ; 2012 ; PLoS ONE links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Nagle AA,Gan FF,Jones G,So CL,Wells G,Chew EH Antitumour benzothiazoles 13.(Diacetoxy)iodobenzene (DAIB) oxidation of 2-(4-hydroxy-3-methoxyphenyl)- benzothiazole and related compounds in the presence of dienophiles. Journal article ; 2000 ; Arkivoc links: IRIS ; publisher authors [click to collapse] : Wells G,Lowe PR,Stevens MFG Design, synthesis and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates. Journal article ; 2006 ; Journal of Medicinal Chemistry links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Wells G,Martin CRH,Howard PW,Sands ZA,Laughton CA,Tiberghien AC,Woo CK,Masterson L,Stephenson MJ,Hartley JA,Jenkins TC,Shnyder SD,Loadman PM,Waring MJ,Thurston DE Design, synthesis, biophysical and biological evaluation of a series of methyl ester-terminated pyrrolobenzodiazepine (PBD)-poly(N-methylpyrrole) conjugates. Conference ; 2005 ; CLINICAL CANCER RESEARCH links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Wells G,Howard PW,Martin C,Sands ZA,Laughton CA,Tiberghien A,Woo CK,Masterson LA,John AI,Jenkins TC,Shnyder SD,Loadman PM,Thurston DE Novel chemoinformatic methods for the design of small molecule gene targetting agents. Conference ; 2003 ; CLINICAL CANCER RESEARCH links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Sands ZA,Wells G,Howard P,Thurston D,Laughton C Structural studies on bioactive compounds. 32. Oxidation of tyrphostin protein tyrosine kinase inhibitors with hypervalent iodine reagents. Journal article ; 2000 ; Journal of Medicinal Chemistry links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Wells G,Seaton A,Stevens MFG