Stapleton, Paul - University College London

个人简介

PhD in Medical Microbiology, UMDS St. Thomas’ Hospital (University of London), 1997

研究领域

Natural product inhibitors of bacterial type IV secretion systems Molecular epidemiology of antibiotic resistance genes/ mechanisms of antibiotic resistance gene translocation Antimicrobial prodrugs (nitrofurans)

近期论文

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Effect of restoration of children's teeth with mercury amalgam on the prevalence of mercury- and antibiotic-resistant oral bacteria. Journal article ; 2003 ; Microbial Drug Resistance links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Pike R,Lucas V,Petrie A,Roberts G,Stapleton PD,Rowbury R,Richards H,Mullany P,Wilson M Prevalence and antibiotic resistance profile of mercury-resistant oral bacteria from children with and without mercury amalgam fillings Journal article ; 2002 ; Journal of Antimicrobial Chemotherapy links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Pike R,Lucas V,Stapleton PD,Gilthorpe G,Roberts R,Rowbury H,Richards P,Mullany P,Wilson M Effect of Medium Composition on the Susceptibility of Oral Streptococci to Mercuric Chloride Journal article ; 2002 ; Current Microbiology links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Pike R,Stapleton PD,Lucas V,Roberts G,Rowbury R,Richards H,Mullany P,Wilson M Characterisation of viridans group streptococci with different levels of Tet(M)-mediated tetracycline resistance. Journal article ; 2004 ; International Journal of Antimicrobial Agents links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Stapleton PD,Adams V,Pike R,Lucas G,Roberts P,Mullany R Mercuric resistance genes in gram-positive oral bacteria. Journal article ; 2004 ; FEMS Microbiology Letters links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Stapleton PD,Pike R,Mullany P,Lucas V,Roberts G,Rowbury M,Wilson M,Richards H Letter to the editor: Transferable resistance to triclosan in MRSA. Journal article ; 1991 ; Lancet links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Cookson BD,Farrelly H,Stapleton PD,Garvey RP,Price MR Ribotyping of coagulase-negative staphylococci. Journal article ; 1992 ; Journal of Medical Microbiology links: IRIS ; UCL Discovery authors [click to collapse] : Cookson BD,Stapleton PD,Ludlam H The ability of beta-lactam antibiotics to select mutants with derepressed beta-lactamase synthesis from Citrobacter freundii. Journal article ; 1995 ; Journal of Antimicrobial Chemotherapy links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Stapleton PD,Shannon KP,Phillips I Incidence and mechanisms of resistance to the combination of amoxicillin and clavulanic acid in Escherichia coli. Journal article ; 1995 ; Antimicrobial Agents and Chemotherapy links: IRIS ; UCL Discovery authors [click to collapse] : Stapleton PD,Wu PJ,King A,Shannon KP,French GL,Phillips I DNA sequence differences of ampD mutants of Citrobacter freundii. Journal article ; 1995 ; Antimicrobial Agents and Chemotherapy links: IRIS ; UCL Discovery authors [click to collapse] : Stapleton PD,Shannon KP,Phillips I Extended-Spectrum ?-Lactamase-Producing Klebsiella pneumoniae Strains Causing Nosocomial Outbreaks of Infection in the United Kingdom Journal article ; 1998 ; Journal of Clinical Microbiology links: IRIS ; UCL Discovery authors [click to collapse] : Shannon KP,Stapleton PD,Xiang X,Johnson A,Beattie H,El Bakri F,Cookson B,French GL An outbreak of extended-spectrum, ?-lactamase-producing Salmonella senftenberg in a burns ward Journal article ; 1998 ; Journal of Hospital Infection links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Revathi G,Shannon KP,Stapleton PD,Jain BK,French GL A hospital outbreak of extended-spectrum ?-lactamase-producing Klebsiella pneumoniae investigated by RAPD typing and analysis of the genetics and mechanisms of resistance Journal article ; 1998 ; Journal of Hospital Infection links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Shannon KP,Fung KW,Stapleton PD,Anthony R,Power E,French GL Construction and Characterization of Mutants of the TEM-1 b-Lactamase Containing Amino Acid Substitutions Associated with both Extended-Spectrum Resistance and Resistance to b-Lactamase Inhibitors Journal article ; 1999 ; Antimicrobial Agents and Chemotherapy links: IRIS ; UCL Discovery authors [click to collapse] : Stapleton PD,Shannon KP,French GL Carbapenem resistance in Escherichia coli associated with plasmid-determined CMY-4 beta-lactamase production and loss of an outer membrane protein. Journal article ; 1999 ; Antimicrobial Agents and Chemotherapy links: IRIS ; UCL Discovery ; publisher authors [click to collapse] : Stapleton PD,Shannon KP,French GL Modulation of beta-lactam resistance in Staphylococcus aureus by catechins and gallates. Journal article ; 2004 ; International Journal of Antimicrobial Agents links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Stapleton PD,Shah S,Anderson JC,Hara Y,Hamilton-Miller JMT,Taylor PW High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity. Journal article ; 2011 ; Chemical Communications links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Patel SM,Fuente MDL,Ke S,Guimar�es AMR,Oliyide AO,Ji X,Stapleton PD,Osbourn A,Pan Y,Bowles DJ,Davis BG,Schatzlein AG,Yang M Abstract: Glycosylation enhances selectivity of novobiocin and alters antibacterial mechanism Journal article ; 2011 ; Abstract of Papers of the American Chemical Society links: IRIS ; UCL Discovery authors [click to collapse] : Guimaraes AMR,Fuente MDL,Stapleton PD,Ji X,Oliyide AO,Osbourn A,Pandit S,Bowles DJ,Davis BG,Schatzlein AG,Yang M New ways to treat bacterial infections Journal article ; 2002 ; Drug Discovery Today links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Taylor PW,Stapleton PD,Luzio JP Methicillin resistance in staphylococcus aureus: mechanisms and modulation Journal article ; 2002 ; Science Progress links: IRIS ; UCL Discovery ; publisher authors : Stapleton PD,Taylor PW Structural pharmacogenomics: the answer to antimicrobial drug resistance? Journal article ; 2002 ; Drug Discovery Today links: IRIS ; UCL Discovery ; doi ; publisher authors : Taylor PW,Stapleton PD Antimicrobial compositions and methods of use Patent ; 2003 links: IRIS ; UCL Discovery authors [click to collapse] : Uesato S,Hara Y,Stapleton PD,Taylor PW Modification of staphylococci by catechin gallates Journal article ; 2004 ; ICOS Proceedings links: IRIS ; UCL Discovery authors [click to collapse] : Taylor PW,Stapleton PD,Shah S,Anderson JC Compounds for use in the treatment of infection Patent ; 2004 links: IRIS ; UCL Discovery authors [click to collapse] : Taylor PW,Stapleton PD,Headley C,Anderson JC Pyrrolobenzodiazepine dimers: novel sequence-selective, DNA-interactive, cross-linking agents with activity against Gram-positive bacteria Journal article ; 2005 ; Journal of Antimicrobial Chemotherapy links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Hadjivassileva T,Stapleton PD,Thurston DE,Taylor PW