Ruiz, Arnaud - University College London

个人简介

BSc Hons in Natural Sciences, University of Aix-Marseille, 1994 PhD in Neurosciences, University of Aix-Marseille, 1998

研究领域

Excitability of cortical circuits in health and disease: This research aims at understanding how presynaptic receptors and ion channels regulate information flow and synaptic plasticity in the normal brain and in mice models of inherited channelopathies. Zinc and inhibition: Zinc is extremely abundant at some excitatory terminals in the forebrain where it modulates glutamate receptors and transporters. However, how it affects inhibitory circuits and interneurone function in cortices remains poorly researched. Latest developments in zinc research can be found on the website of the International Society for Zinc Biology. Information processing in dendrites: We study layer 2/3 cortical pyramids with multi-photon imaging and laser-guided glutamate uncaging at nearby dendritic spines. Central to this research is the role of dendritic K+ channels in shaping the integration of glutamatergic events evoked at single synaptic sites. The data generated will be integrated in a large scale model of cortical function as part of the Human Brain Project initiative. Drug discovery: Developing selective glutamate receptor ligands offers great therapeutic potential to interact with brain circuits. In collaboration with Dr Steve Hilton we have synthesised and discovered a new family of molecules that could act as nootropic drugs to treat memory related disorders.

近期论文

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Endogenous zinc depresses GABAergic transmission via T-type Ca2+ channels and broadens the time-window for integration of glutamatergic inputs in dentate granule cells. Journal article ; 2013 ; The Journal of Physiology ; United Kingdom links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Grauert A,Engel D,Ruiz AJ Presynaptic GABAA receptors enhance transmission and LTP induction at hippocampal mossy fiber synapses Journal article ; 2010 ; Nature Neuroscience ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Ruiz A,Campanac E,Scott RS,Rusakov DA,Kullmann DM Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures Journal article ; 2015 ; NATURE COMMUNICATIONS ; NATURE PUBLISHING GROUP links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Stodberg T,McTague A,Ruiz AJ,Hirata H,Zhen J,Long P,Farabella I,Meyer E,Kawahara A,Vassallo G,Stivaros SM,Bjursell MK,Stranneheim H,Tigerschiold S,Persson B,Bangash I,Das K,Hughes D,Lesko N,Lundeberg J,Scott RC,Poduri A,Scheffer IE,Smith H,Gissen P,Schorge S,Reith MEA,Topf M,Kullmann DM,Harvey RJ,Wedell A,Kurian MA Presynaptic GABAA receptors enhance transmission and LTP induction at hippocampal mossy fibre synapses Poster ; 2010 ; Senate House, London, UK links: IRIS ; UCL Discovery authors [click to collapse] : Ruiz AJ,Campanac E,Scott R,Rusakov DA,Kullmann DM Endogenous zinc modulates di-synaptic GABAergic transmission in the dentate gyrus Poster ; 2011 ; Institute of Education, London, UK links: IRIS ; UCL Discovery authors [click to collapse] : Grauert A,Engel D,Ruiz AJ Mossy fiber zinc modulates di-synaptic GABAergic transmission and tunes the integration window of excitatory synaptic input Poster ; 2012 ; Institute of Education, London, UK links: IRIS ; UCL Discovery authors [click to collapse] : Grauert A,Engel D,Ruiz AJ Zinc-mediated modulation of GABAA receptors at hippocampal mossy fibres. Conference presentation ; 2008 ; Banff links: IRIS ; UCL Discovery ; publisher authors : Ruiz AJ Endogenous zinc modulates GABAergic inhibition at a hippocampal pathway. Conference presentation ; 2009 ; Jerusalem links: IRIS ; UCL Discovery ; publisher authors : Ruiz AJ Endogenous zinc depresses feedback GABAergic transmission and broadens de window for integration of excitatory synaptic inputs. Conference presentation ; 2012 ; Melbourne links: IRIS ; UCL Discovery ; publisher authors : Ruiz AJ Modulation of axonal excitability by ionotropic receptors. Conference presentation ; 2012 ; International Neuroscience Symposium of the Collaborative Research Center of the Deutsche Forschungsgemeinschaft links: IRIS ; UCL Discovery ; publisher authors : Ruiz AJ Presynaptic GABAA receptors enhance glutamatergic transmission and facilitate LTP induction at hippocampal mossy fibre synapses Poster ; 2010 ; RAI Convention Centre, Amsterdam, The Netherlands links: IRIS ; UCL Discovery authors [click to collapse] : Ruiz AJ,Campanac E,Scott R,Rusakov D,Kullmann D Endogenous zinc modulates dentate gyrus feed-back inhibition Poster ; 2010 ; RAI Convention Centre, Amsterdam, The Netherlands links: IRIS ; UCL Discovery authors [click to collapse] : Grauert A,Engel D,Ruiz AJ Clausenamide and Kainic Acid via a Novel Intramolecular Acylal Cyclisation (IAC). Poster ; 2011 ; Churchill College, Cambridge links: IRIS ; UCL Discovery authors [click to collapse] : Szulc B,Ruiz AJ,Hilton S Lewis Acid Mediated Intramolecular Acylal Cyclisation (IAC) as a Novel Approach Towards Nootropic Compounds. Poster ; 2011 ; University of Cambridge links: IRIS ; UCL Discovery authors [click to collapse] : Szulc B,Ruiz AJ,Hilton S Ionotropic receptors at hippocampal mossy fibres: roles in axonal excitability, synaptic transmission and plasticity Journal article ; 2012 ; Frontiers in Neural Circuits links: IRIS ; UCL Discovery ; doi authors : Ruiz AJ,Kullmann D Presynaptic, extrasynaptic and axonal GABA(A) receptors in the CNS: where and why? Journal article ; 2005 ; Progress in Biophysics and Molecular Biology links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Kullmann DM,Ruiz A,Rusakov DM,Scott R,Semyanov A,Walker MC Endogenous zinc inhibits GABA(A) receptors in a hippocampal pathway Journal article ; 2004 ; Journal of Neurophysiology links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Ruiz A,Walker MC,Fabian-Fine R,Kullmann DM Blocking the trigeminal EPSP in rat abducens motoneurons in vivo with the AMPA antagonists NBQX and GYKI 53655. Journal article ; 2000 ; Brain Research Bulletin links: IRIS ; UCL Discovery ; doi ; publisher authors : Ruiz A,Durand J AMPA receptor antagonists, GYKI 52466 and NBQX, do not block the induction of long-term potentiation at therapeutically relevant concentrations Journal article ; 2000 ; Brain Research Bulletin links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Kapus G,Szekely JI,Durand J,Ruiz A,Tarnawa I Modulation of kainate-induced responses by pentobarbitone and GYKI- 53784 in rat abducens motoneurons in vivo Journal article ; 1999 ; Brain Research links: IRIS ; UCL Discovery ; doi authors : Ruiz A,Durand J Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses Journal article ; 2005 ; Journal of Neuroscience links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Ruiz A,Sachidhanandam S,Utvik JK,Coussen F,Mulle C A delayed response enhancement during hippocampal presynaptic plasticity in mice Journal article ; 2007 ; Journal of Physiology links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Jensen V,Walaas SI,Hilfiker S,Ruiz A,Hvalby Ø Kainate receptors with a metabotropic signature enhance hippocampal excitability by regulating the slow after-hyperpolarization in CA3 pyramidal neurons. Chapter ; 2011 ; Kainate receptors: ; Springer links: IRIS ; doi ; publisher authors : Ruiz A GABA(A) receptors at hippocampal mossy fibers Journal article ; 2003 ; Neuron links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Ruiz A,Fabian-Fine R,Scott R,Walker MC,Rusakov DA,Kullmann DM GABA and GABAA receptors at hippocampal mossy fibre synapses Journal article ; 2003 ; European Journal of Neuroscience links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Bergersen L,Ruiz A,Bjaalie JG,Kullmann DM,Gundersen V