Parkinson, Gary - University College London

个人简介

BSc Hons in Geology, Bedford College, 1984 MSc in Crystallography, Birkbeck College, 1988 PhD in Crystallography, University of Pittsburgh, USA, 1995

研究领域

Structural based investigations of STAT3 protein-protein interactions and DNA-protein interactions as a pathway to drug discovery Exploring the roles of DNA/RNA quadruplex structures play in human diseases Elucidating a molecular basis of frontotemporal dementia and related disorders through higher ordered RNA motifs

近期论文

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HELIX: a new modular nucleic acid crystallization screen Journal article ; 2014 ; JOURNAL OF APPLIED CRYSTALLOGRAPHY links: IRIS ; UCL Discovery ; doi ; author's authors : Viladoms J,Parkinson GN STRUCTURE OF A PLATINUM(II) COMPLEX OF LEVAMISOLE Journal article ; 1993 ; ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : ARVANITIS G,BERARDINI M,PARKINSON G,SCHNEIDER B Aromatic hydrogen bond in sequence-specific protein DNA recognition Journal article ; 1996 ; Nature Structural Biology links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Parkinson G,Gunasekera A,Vojtechovsky J,Zhang X,Kunkel TA,Berman H,Ebright RH Crystal and molecular structure of a new Z-DNA crystal form: d[CGT(2-NH2-A)CG] and its platinated derivative. Journal article ; 1995 ; Biochemistry ; United States links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Parkinson GN,Arvanitis GM,Lessinger L,Ginell SL,Jones R,Gaffney B,Berman HM Structure of the CAP-DNA complex at 2.5 angstroms resolution: a complete picture of the protein-DNA interface. Journal article ; 1996 ; J Mol Biol ; England links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Parkinson G,Wilson C,Gunasekera A,Ebright YW,Ebright RH,Berman HM New parameters for the refinement of nucleic acid-containing structures Journal article ; 1996 ; Acta Crystallographica Section D Biological Crystallography links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Parkinson G,Vojtechovsky J,Clowney L,Brünger AT,Berman HM A regular thymine tetrad and a peculiar supramolecular assembly in the first crystal structure of an all-LNA G-quadruplex. Journal article ; 2014 ; Acta Crystallogr D Biol Crystallogr ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Russo Krauss I,Parkinson GN,Merlino A,Mattia CA,Randazzo A,Novellino E,Mazzarella L,Sica F Crystal structure of a promoter sequence in the B-raf gene reveals an intertwined dimer quadruplex. Journal article ; 2013 ; J Am Chem Soc ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Wei D,Todd AK,Zloh M,Gunaratnam M,Parkinson GN,Neidle S Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography Journal article ; 2013 ; FEBS Letters links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Nkansah E,Shah R,Collie GW,Parkinson GN,Palmer J,Rahman KM,Bui TT,Drake AF,Husby J,Neidle S,Zinzalla G,Thurston DE,Wilderspin AF Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. Journal article ; 2013 ; FEBS Lett ; England links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Nkansah E,Shah R,Collie GW,Parkinson GN,Palmer J,Rahman KM,Bui TT,Drake AF,Husby J,Neidle S,Zinzalla G,Thurston DE,Wilderspin AF Characterisation of ilomastat for prolonged ocular drug release Journal article ; 2012 ; AAPS PharmSciTech links: IRIS ; doi authors [click to collapse] : Parkinson G,Gaisford S,Ru Q,Lockwood A,Khalili A,Sheridan R,Khaw PT,Brocchini S,Fadda HM Nanofiber-based delivery of therapeutic peptides to the brain. Journal article ; 2013 ; ACS Nano ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Mazza M,Notman R,Anwar J,Rodger A,Hicks M,Parkinson G,McCarthy D,Daviter T,Moger J,Garrett N,Mead T,Briggs M,Schätzlein AG,Uchegbu IF C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes. Journal article ; 2012 ; Sci Rep ; England links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Fratta P,Mizielinska S,Nicoll AJ,Zloh M,Fisher EM,Parkinson G,Isaacs AM Characterisation of Ilomastat for Prolonged Ocular Drug Release Journal article ; 2012 ; AAPS PharmSciTech links: IRIS ; UCL Discovery authors [click to collapse] : Parkinson G,Gaisford S,Ru Q,Lockwood A,Khalili A,Sheridan R,Khaw PT,Brocchini S,Fadda HM Crystal structure of FMN-dependent nitroreductase from Escherichia coli B: a prodrug-activating enzyme. Journal article ; 2000 ; J Med Chem ; United States links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Parkinson GN,Skelly JV,Neidle S Crystal structure of the potassium form of an Oxytricha nova G-quadruplex. Journal article ; 2002 ; J Mol Biol ; England links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Haider S,Parkinson GN,Neidle S DNA quadruplexes: Structures and their recognition. Conference ; 2003 ; ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Neidle S,Parkinson GN,Lee M,Chessari G,Haider S Evaluation of strong binding interaction of a linear biphenyl benzimidazole diamidine in the DNA minor groove Conference ; 2006 ; ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Miao Y,Lee MPH,Parkinson GN,Batista-Parra A,Ismail MA,Neidle S,Boykin DW,Wilson WD Structure-based design and evaluation of small molecules with selectivity for telomeric quadruplex nucleic acids Journal article ; 2010 ; ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Gunaratnam M,Hempel S,Collie G,Sparapani S,Campbell N,Parkinson G,de la Fuente M,Schatzlein A,Neidle S A thymine tetrad in d(TGGGGT) quadruplexes stabilized with Tl+/Na+ ions Journal article ; 2004 ; NUCLEIC ACIDS RESEARCH links: IRIS ; UCL Discovery ; doi ; author's ; publisher authors [click to collapse] : Caceres C,Wright G,Gouyette C,Parkinson G,Subirana JA Crystal structure of parallel quadruplexes from human telomeric DNA Journal article ; 2002 ; Nature links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Parkinson GN,Lee MPH,Neidle S Structural characterization and antimicrobial evaluation of atractyloside, atractyligenin, and 15-didehydroatractyligenin methyl ester. Journal article ; 2012 ; J Nat Prod ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Brucoli F,Borrello MT,Stapleton P,Parkinson GN,Gibbons S Isolation and characterization of a new anticancer diterpenoid from Jatropha gossypifolia Journal article ; 2012 ; Pharmaceutical Chemistry Journal links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Falodun A,Sheng-Xiang Q,Parkinson G,Gibbons S Solution structure of a 2:1 C2-(2-naphthyl)pyrrolo[2,1-c][1,4]-benzodiazepine (PBD) DNA adduct: molecular basis for unexpectedly high DNA helix stabilization Conference ; 2008 ; EJC SUPPLEMENTS links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Antonow D,Barata T,Jenkins TC,Parkinson GN,Howard PW,Zloh M,Thurston DE Isolation and characterization of a new anticancer diterpenoid from Jatropha gossypifolia Journal article ; 2012 ; Pharmaceutical Chemistry Journal links: IRIS ; UCL Discovery authors [click to collapse] : Falodun A,Sheng-Xiang Q,Parkinson G,Gibbons S