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个人简介

Diploma work in Chemistry/Biochemistry, University of Hamburg, Germany/University of Sevilla, Spain, 1993 PhD in Chemistry (Structural Biology), University of Hamburg/Max-Planck Working Groups for Structural Biology, Germany, 1997

研究领域

Kinesins as potential targets for drug development in cancer chemotherapy Development of resistance to antimitotic agents Structure-based drug design Structure and function of the kinesin-1 complex

近期论文

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A program for automated optimization of initial crystallization conditions Journal article ; 2006 ; Journal of Applied Crystallography links: IRIS ; UCL Discovery ; doi authors : Ben Haj Abdellatif T,Kozielski F Synthesis of 5-acyl-3,4-dihydropyrimidine-2-thiones via solvent-free, solution-phase and solid-phase Biginelli procedures Journal article ; 2009 ; Synlett links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Comas H,Buisson DA,Najman R,Kozielski F,Rousseau B,Lopez R Crystallization and preliminary X-ray analysis of the single-headed and double-headed motor protein kinesin. Journal article ; 1997 ; J Struct Biol ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Kozielski F,Schönbrunn E,Sack S,Müller J,Brady ST,Mandelkow E The crystal structure of dimeric kinesin and implications for microtubule-dependent motility. Journal article ; 1997 ; Cell ; United States links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Kozielski F,Sack S,Marx A,Thormählen M,Schönbrunn E,Biou V,Thompson A,Mandelkow EM,Mandelkow E A model of the microtubule-kinesin complex based on electron cryomicroscopy and X-ray crystallography. Journal article ; 1998 ; Curr Biol ; England links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Kozielski F,Arnal I,Wade RH The crystal structure of the minus-end-directed microtubule motor protein ncd reveals variable dimer conformations. Journal article ; 1999 ; Structure ; United States links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Kozielski F,De Bonis S,Burmeister WP,Cohen-Addad C,Wade RH Structural links to kinesin directionality and movement. Journal article ; 2000 ; Nat Struct Biol ; United States links: IRIS ; UCL Discovery ; doi ; author's authors : Wade RH,Kozielski F The overall conformation of conventional kinesins studied by small angle X-ray and neutron scattering. Journal article ; 2001 ; J Biol Chem ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Kozielski F,Svergun D,Zaccai G,Wade RH,Koch MH Conformation of the Drosophila motor protein non-claret disjunctional in solution from X-ray and neutron scattering. Journal article ; 2001 ; J Biol Chem ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Svergun DI,Zaccai G,Malfois M,Wade RH,Koch MH,Kozielski F Interaction of the mitotic inhibitor monastrol with human kinesin Eg5. Journal article ; 2003 ; Biochemistry ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : DeBonis S,Simorre JP,Crevel I,Lebeau L,Skoufias DA,Blangy A,Ebel C,Gans P,Cross R,Hackney DD,Wade RH,Kozielski F Crystallization and preliminary crystallographic analysis of the motor domain of human kinetochore-associated protein CENP-E using an automated crystallization procedure. Journal article ; 2004 ; Acta Crystallogr D Biol Crystallogr ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Garcia-Saez I,Blot D,Kahn R,Kozielski F Crystal structure of the motor domain of the human kinetochore protein CENP-E. Journal article ; 2004 ; J Mol Biol ; England links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Garcia-Saez I,Yen T,Wade RH,Kozielski F Automated analysis of vapor diffusion crystallization drops with an X-ray beam. Journal article ; 2004 ; Structure ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Jacquamet L,Ohana J,Joly J,Borel F,Pirocchi M,Charrault P,Bertoni A,Israel-Gouy P,Carpentier P,Kozielski F,Blot D,Ferrer JL In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities. Journal article ; 2004 ; Mol Cancer Ther ; United States links: IRIS ; UCL Discovery ; author's authors [click to collapse] : DeBonis S,Skoufias DA,Lebeau L,Lopez R,Robin G,Margolis RL,Wade RH,Kozielski F Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5. Journal article ; 2004 ; Biochemistry ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Brier S,Lemaire D,Debonis S,Forest E,Kozielski F Essential kinesins: characterization of Caenorhabditis elegans KLP-15. Journal article ; 2005 ; Biochemistry ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Robin G,DeBonis S,Dornier A,Cappello G,Ebel C,Wade RH,Thierry-Mieg D,Kozielski F Use of hydrogen/deuterium exchange mass spectrometry and mutagenesis as a tool to identify the binding region of inhibitors targeting the human mitotic kinesin Eg5. Journal article ; 2006 ; Rapid Commun Mass Spectrom ; England links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Brier S,Lemaire D,DeBonis S,Kozielski F,Forest E S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression. Journal article ; 2006 ; J Biol Chem ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Skoufias DA,DeBonis S,Saoudi Y,Lebeau L,Crevel I,Cross R,Wade RH,Hackney D,Kozielski F Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents. Journal article ; 2006 ; J Mol Biol ; England links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Brier S,Lemaire D,DeBonis S,Forest E,Kozielski F The structure of human neuronal Rab6B in the active and inactive form. Journal article ; 2006 ; Acta Crystallogr D Biol Crystallogr ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Garcia-Saez I,Tcherniuk S,Kozielski F Human kinetochore-associated kinesin CENP-E visualized at 17 A resolution bound to microtubules. Journal article ; 2006 ; J Mol Biol ; England links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Neumann E,Garcia-Saez I,DeBonis S,Wade RH,Kozielski F,Conway JF First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value. Journal article ; 2006 ; Acta Crystallogr D Biol Crystallogr ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Banci L,Bertini I,Cusack S,de Jong RN,Heinemann U,Jones EY,Kozielski F,Maskos K,Messerschmidt A,Owens R,Perrakis A,Poterszman A,Schneider G,Siebold C,Silman I,Sixma T,Stewart-Jones G,Sussman JL,Thierry JC,Moras D The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins. Journal article ; 2006 ; Biochemistry ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Brier S,Carletti E,DeBonis S,Hewat E,Lemaire D,Kozielski F Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration. Journal article ; 2007 ; J Biol Chem ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Garcia-Saez I,DeBonis S,Lopez R,Trucco F,Rousseau B,Thuéry P,Kozielski F New chemical tools for investigating human mitotic kinesin Eg5. Journal article ; 2007 ; Bioorg Med Chem ; England links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Klein E,DeBonis S,Thiede B,Skoufias DA,Kozielski F,Lebeau L

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