Healy, Jess - University College London

个人简介

BSc Chem (Hons), 1st, University College Cork, 2006 PhD in Medical Sciences, University of Aberdeen, 2010

研究领域

The use of synthetic chemistry to develop tool compounds to further our understanding of biological processes and to develop novel therapies Fragment based drug discovery and kinetic target guided synthesis for lead/tool molecule identification Development of bespoke libraries and novel chemistries compatible with kinetic target guided synthesis Particular therapeutic area of interest is antimicrobial resistance and we have a number of projects ongoing in this area. Targets under investigation include thiol dependant detoxification enzymes such as the glyoxalases and S-transferases, beta-lactamases and cell biosynthesis Research Cluster: Drug Discovery

近期论文

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Understanding the structural requirements for activators of the kef bacterial potassium efflux system Journal article ; 2014 ; Biochemistry links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Healy J,Ekkerman S,Pliotas C,Richard M,Bartlett W,Grayer SC,Morris GM,Miller S,Booth IR,Conway SJ,Rasmussen T KefF, the Regulatory Subunit of the Potassium Efflux System KefC, Shows Quinone Oxidoreductase Activity Journal article ; 2011 ; Journal of Bacteriology links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Lyngberg L,Healy J,Bartlett W,Miller S,Conway SJ,Booth IR,Rasmussen T Mechanism of ligand-gated potassium efflux in bacterial pathogens Journal article ; 2010 ; Proceedings of the National Academy of Sciences links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Roosild TP,Castronovo S,Healy J,Miller S,Pliotas C,Rasmussen T,Bartlett W,Conway SJ,Booth IR The photochemical thiol-ene reaction as a versatile method for the synthesis of glutathione S-conjugates targeting the bacterial potassium efflux system Kef Journal article ; 2016 ; Organic Chemistry Frontiers ; UK links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Healy JESS,Conway SJ,Rasmussen T,Miller S,Booth IR