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个人简介

MD PhD, University of Hamburg, Germany, 2000 MBBS (Bachelor of Medicine/Bachelor of Surgery), University of Hamburg, Germany, 1997

研究领域

The role of the Parkinson's disease protein kinase LRRK2 in Wingless/Int (Wnt) signalling The role of the Parkinson's disease protein kinase LRRK2 at the cytoskeleton Trapping and accumulation of inhibitory GABAA and glycine receptors at synapses

近期论文

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Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: Focus on Parkinson's disease kinases, GTPases, and ATPases Journal article ; 2014 ; Frontiers in Molecular Neuroscience links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Taymans JM,Baekelandt V,Harvey K GlyR alpha3:an essential target for spinal PGE2-mediated inflammatory pain sensitization Journal article ; 2004 ; Science links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Harvey RJ,Depner UB,Wassle H,Ahmadi S,Heindl C,Reinold H,Smart TG,Harvey K,Schutz B,Abo-Salem OM,Zimmer A,Poisbeau P,Welzl H,Wolfer DP,Betz H,Zeilhofer HU,Muller U Regulating Wnt signaling: a strategy to prevent neurodegeneration and induce regeneration. Journal article ; 2014 ; J Mol Cell Biol ; United States links: IRIS ; UCL Discovery ; doi ; author's authors : Harvey K,Marchetti B A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation. Journal article ; 2014 ; J Biol Chem ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Law BM,Spain VA,Leinster VH,Chia R,Beilina A,Cho HJ,Taymans JM,Urban MK,Sancho RM,Blanca Ramírez M,Biskup S,Baekelandt V,Cai H,Cookson MR,Berwick DC,Harvey K The regulation and deregulation of Wnt signaling by PARK genes in health and disease. Journal article ; 2014 ; J Mol Cell Biol ; United States links: IRIS ; UCL Discovery ; doi ; author's authors : Berwick DC,Harvey K LRRK2: an éminence grise of Wnt-mediated neurogenesis? Journal article ; 2013 ; Frontiers in cellular neuroscience links: IRIS ; UCL Discovery ; doi ; publisher authors : Harvey K The Parkinson's disease protein LRRK2: at the centre of multiple cell biological functions Conference ; 2013 ; JOURNAL OF NEUROCHEMISTRY links: IRIS ; UCL Discovery ; author's authors : Berwick DC,Harvey K The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Journal article ; 2007 ; Nature Cell Biology links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Plun-Favreau H,Klupsch K,Moisoi N,Gandhi S,Kjaer S,Frith D,Harvey K,Deas E,Harvey RJ,McDonald N,Wood NW,Martins LM,Downward J Novel missense mutations in the glycine receptor β subunit gene (GLRB) in startle disease. Journal article ; 2013 ; Neurobiol Dis ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : James VM,Bode A,Chung SK,Gill JL,Nielsen M,Cowan FM,Vujic M,Thomas RH,Rees MI,Harvey K,Keramidas A,Topf M,Ginjaar I,Lynch JW,Harvey RJ Isoform heterogeneity of the human gephyrin gene (GPHN), binding domains to the glycine receptor and mutation analysis in hyperekplexia Journal article ; 2003 ; Journal of Biological Chemistry links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Rees MI,Harvey K,Ward H,White JH,Evans L,Duguid IC,Hsu CC,Coleman SL,Miller J,Baer K,Waldvogel HJ,Gibbon F,Smart TG,Owen MJ,Harvey RJ,Snell RG Altered cleavage and localisation of PINK1 to aggresomes in the presence of proteasomal stress Journal article ; 2006 ; Journal of Neurochemistry links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Muqit MMK,Abou-Sleiman PM,Saurin AT,Harvey K,Gandhi S,Deas E,Eaton S,Payne Smith MD,Venner K,Matilla A,Healy DG,Gilks WP,Lees AJ,Holton J,Revesz T,Parker PJ,Harvey RJ,Wood NW,Latchman DS The importance of Wnt signalling for neurodegeneration in Parkinson's disease Journal article ; 2012 ; Biochemical Society Transactions links: IRIS ; UCL Discovery ; doi authors : Berwick DC,Harvey K Kinase activity is required for dominant effects of mutant dardarin. Journal article ; 2006 ; Neurobiology of Disease links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Greggio E,Jain S,Kingsbury AE,Bandopadhyay R,Kaganovich A,Lewis P,van der Brug MP,Beilina A,Blackinton J,Thomas KJ,Ahmad R,Miller DW,Lees A,Harvey RJ,Harvey K,Cookson MR LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6 Journal article ; 2012 ; Hum Mol Genet links: IRIS ; UCL Discovery ; doi ; author's authors : Berwick DC,Harvey K N-terminal histidine regulates zinc inhibition on the murine GABA-A receptor beta3 subunit Journal article ; 2002 ; British Journal of Pharmacology links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Dunne EL,Hosie AM,Wooltorton JRA,Duguid IC,Harvey K,Moss SJ,Harvey RJ,Smart TG Hereditary early-onset Parkinson's disease caused by mutations in PINK1 Journal article ; 2004 ; Science links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Valente EM,Abou-Sleiman PM,Caputo V,Muqit MMK,Harvey K,Gispert S,Ali Z,Del Turco D,Bentivoglio AR,Healy DG,Albanese A,Nussbaum R,Gonzalez-Maldonado R,Deller T,Salvi S,Cortelli P,Gilks WP,Latchman DS,Harvey RJ,Dallapiccola B,Auburger G,Wood NW Frontal lobe dysfunction in sporadic hyperekplexia - case study and literature review Journal article ; 2004 ; Journal of Neurology links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Gaitatzis A,Kartsounis LD,Gacinovic S,Costa DC,Harvey K,Harvey RJ,Silva RN Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways. Journal article ; 2009 ; Human Molecular Genetics links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Sancho RM,Law BMH,Harvey K Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant Journal article ; 2010 ; Journal of Neurochemistry links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Dani�ls V,Vancraenenbroeck R,Law BMH,Greggio E,Lobbestael E,Gao F,De Maeyer M,Cookson MR,Harvey K,Baekelandt V,Taymans JM Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses Journal article ; 2011 ; Journal of Cell Science links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Tyagarajan SK,Ghosh H,Harvey K,Fritschy JM LRRK2 signaling pathways: the key to unlocking neurodegeneration? Journal article ; 2011 ; Trends in Cell Biology links: IRIS ; UCL Discovery ; doi ; publisher authors : Berwick DC,Harvey K Diversity of glycine receptors in the mouse retina: localization of the alpha3 subunit Journal article ; 2003 ; Journal of Comparative Neurology links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Haverkamp S,Muller U,Harvey K,Harvey RJ,Betz H,Wassle H Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease Journal article ; 2006 ; Nature Genetics links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Rees MI,Harvey K,Pearce BR,Chung SK,Duguid IC,Thomas P,Beatty S,Graham GE,Armstrong L,Shiang R,Abbott KJ,Zuberi SM,Stephenson JBP,Owen MJ,Tijssen MAJ,van den Maagdenberg AMJM,Smart TG,Supplisson S,Harvey RJ Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice. Journal article ; 2007 ; EMBO Journal links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Papadopoulos T,Korte M,Eulenburg V,Kubota H,Retiounskaia M,Harvey RJ,Harvey K,O'Sullivan GA,Laube B,Hulsmann S,Geiger JR,Betz H A critical role for glycine transporters in hyperexcitability disorders. Journal article ; 2008 ; Frontiers in Molecular Neuroscience links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Harvey RJ,Carta E,Pearce BR,Chung SK,Supplisson S,Rees MI,Harvey K

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