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个人简介

MSc/MSc (Biochemistry) 1998, Aligarh Muslim University MRes (Bioinformatics) 1999, University of Leeds PhD in Molecular Biophysics, The Institute of Cancer Research, UK, 2003

研究领域

Computational validation and structural bioinformatics of targets in Cancer Structural-phenotype relationship of proteins in Gaucher’s disease Structure-based drug design of Antibacterial compounds Structural Bioinformatics of G-quadruplexes

近期论文

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Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly Journal article ; 2014 ; Nature Communications links: IRIS ; doi authors [click to collapse] : Majkut J,Sgobba M,Holohan C,Crawford N,Logan AE,Kerr E,Higgins CA,Redmond KL,Riley JS,Stasik I,Fennell DA,Van Schaeybroeck S,Haider S,Johnston PG,Haigh D,Longley DB Identification of residues contributing to the ATP binding site of Kir6.2 Journal article ; 2003 ; EMBO Journal links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Trapp S,Haider S,Jones P,Sansom MSP,Ashcroft FM Anthrax SET Protein: A POTENTIAL VIRULENCE DETERMINANT THAT EPIGENETICALLY REPRESSES NF- B ACTIVATION IN INFECTED MACROPHAGES Journal article ; 2013 ; Journal of Biological Chemistry links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Mujtaba S,Winer BY,Jaganathan A,Patel J,Sgobba M,Schuch R,Gupta YK,Haider S,Wang R,Fischetti VA Structure-phenotype correlations of human CYP21A2 mutations in congenital adrenal hyperplasia Journal article ; 2013 ; Proceedings of the National Academy of Sciences links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Haider S,Islam B,D'Atri V,Sgobba M,Poojari C,Sun L,Yuen T,Zaidi M,New MI N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines. Journal article ; 2013 ; Chem Biol Drug Des ; England links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Brossard D,Zhang Y,Haider SM,Sgobba M,Khalid M,Legay R,Duterque-Coquillaud M,Galera P,Rault S,Dallemagne P,Moslemi S,El Kihel L Chapter 2: Molecular dynamics and force field based methods for studying quadruplex nucleic acids Journal article ; 2012 ; RSC Biomolecular Sciences links: IRIS ; UCL Discovery authors : Haider SM,Neidle S Conformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale. Journal article ; 2013 ; Nucleic Acids Res ; England links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Islam B,Sgobba M,Laughton C,Orozco M,Sponer J,Neidle S,Haider S A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes Journal article ; 2009 ; Biochemical Society Symposium links: IRIS ; UCL Discovery authors : Haider SM,Neidle S Crystal structure of the potassium form of an Oxytricha nova G-quadruplex Journal article ; 2002 ; Journal of Molecular Biology links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Haider S,Parkinson GN,Neidle S Ion channel gates: comparative analysis of energy barriers Journal article ; 2009 ; European Biophysics Journal links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Tai K,Haider SM,Grottesi A,Sansom MSP Molecular dynamics studies of the STAT3 homodimer:DNA complex: relationships between STAT3 mutations and protein-DNA recognition. Journal article ; 2012 ; J Chem Inf Model ; United States links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Husby J,Todd AK,Haider SM,Zinzalla G,Thurston DE,Neidle S Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. Journal article ; 2004 ; Bioorganic and Medicinal Chemistry Letters links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Harrison RJ,Reszka AP,Haider SM,Romagnoli B,Morrell J,Read MA,Gowan SM,Incles CM,Kelland LR,Neidle S Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands. Journal article ; 2008 ; Molecular Biosystems links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Moorhouse AD,Gunaratnam M,Haider SM,Munnur D,Neidle S,Moses JE Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands. Journal article ; 2008 ; Bioorganic and Medicinal Chemistry Letters links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Cuenca F,Greciano O,Gunaratnam M,Haider SM,Munnur D,Nanjunda R,Wilson WD,Neidle S Targeting human gastrointestinal stromal tumour cells with a quadruplex-binding small molecule. Journal article ; 2009 ; Journal of Medicinal Chemistry links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Gunaratnam M,Swank S,Haider SM,Galesa K,Reszka AP,Beltran M,Cuenca F,Fletcher JA,Neidle S Biaryl polyamides as a new class of DNA quadruplex-binding ligands. Journal article ; 2009 ; Chemical Communications links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Rahman KM,Reszka AP,Gunaratnam M,Haider SM,Howard PW,Fox KR,Neidle S,Thurston DE A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes. Journal article ; 2009 ; Biochemical Society Transactions links: IRIS ; UCL Discovery ; doi ; publisher authors : Haider SM,Neidle S Structure-based design of selective high-affinity telomeric quadruplex-binding ligands. Journal article ; 2010 ; Chemical Communications links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Lombardo CM,Mart�nez IS,Haider SM,Gabelica V,De Pauw E,Moses JE,Neidle S Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes. Journal article ; 2010 ; Journal of the American Chemical Society links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Sparapani S,Haider SM,Doria F,Gunaratnam M,Neidle S Molecular modeling and simulation of G-quadruplexes and quadruplex-ligand complexes. Chapter ; 2010 ; G-Quadruplex DNA: Methods and Protocols ; Humana Press links: IRIS ; UCL Discovery ; doi ; publisher authors : Haider SM,Neidle S Bis-guanylhydrazone diimidazo[1,2-a:1,2-c]pyrimidine as a novel and specific G-quadruplex binding motif. Journal article ; 2010 ; Chemical Communications links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Sparapani S,Bellini S,Gunaratnam M,Haider SM,Andreani A,Rambaldi M,Locatelli A,Morigi R,Granaiola M,Varoli L,Burnelli S,Leoni A,Neidle S A click chemistry approach to C3 symmetric, G-quadruplex stabilising ligands. Journal article ; 2010 ; Organic and Biomolecular Chemistry links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Moses J,Ritson D,Zhang F,Lombardo CM,Haider SM,Oldham N,Neidle S Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy. Journal article ; 2010 ; Journal of Molecular Biology links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Haider SM,Patel J,Poojari C,Neidle S The triazatruxene derivative azatrux binds to the parallel form of the human telomeric G-quadruplex under molecular crowding conditions: Biophysical and molecular modeling studies Journal article ; 2011 ; Biochimie links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Petraccone L,Fotticchia I,Cummaro A,Pagano B,Ginnari-Satriani L,Haider SM,Randazzo A,Novellino E,Neidle S,Giancola C On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis Journal article ; 2011 ; Bioorganic & Medicinal Chemistry Letters links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Haider SM,Joseph CG,Neidle S,Fierke CA,Fuchter MJ

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