Constanti, Andrew - University College London

个人简介

BSc Hons in Pharmacy, First Class, Brighton Polytechnic, 1971 PhD in Pharmacology, University of London, 1975

研究领域

Intracellular recording from cortical neurones Mechanism of anticonvulsant action of new antiepileptic drugs The role of neuroinflammation in the development of hyposmia in an early stage model of Parkinson’s disease (ESPD): investigation of the neuroprotective role of the anti-diabetic peptide exendin in ESPD The role of the mTOR signalling pathway and neuroinflammation in epileptogenesis studied in a genetic absence epilepsy model

近期论文

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Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release Journal article ; 2014 ; Brain, Behavior, and Immunity links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Russo E,Andreozzi F,Iuliano R,Dattilo V,Procopio T,Fiume G,Mimmi S,Perrotti N,Citraro R,Sesti G,Constanti A,De Sarro G Atypical “seizure-like” activity in cortical reverberating networks in vitro can be caused by LPS-induced inflammation: A multi-electrode array study from a hundred neurons Journal article ; 2014 ; Frontiers in Cellular Neuroscience links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Gullo F,Amadeo A,Donvito G,Lecchi M,Costa B,Constanti A,Wanke E Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release. Journal article ; 2014 ; Brain Behav Immun ; Netherlands links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Russo E,Andreozzi F,Iuliano R,Dattilo V,Procopio T,Fiume G,Mimmi S,Perrotti N,Citraro R,Sesti G,Constanti A,De Sarro G The mTOR signaling pathway and neuronal stem/progenitor cell proliferation in the hippocampus are altered during the development of absence epilepsy in a genetic animal model Journal article ; 2014 ; Neurological Sciences links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Russo E,Follesa P,Citraro R,Camastra C,Donato A,Isola D,Constanti A,De Sarro G,Donato G Endogenous cholinergic tone modulates spontaneous network level neuronal activity in primary cortical cultures grown on multi-electrode arrays. Journal article ; 2013 ; BMC Neurosci ; England links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Hammond MW,Xydas D,Downes JH,Bucci G,Becerra V,Warwick K,Constanti A,Nasuto SJ,Whalley BJ MTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsy Journal article ; 2013 ; Neuropharmacology links: IRIS ; UCL Discovery ; doi authors [click to collapse] : Russo E,Citraro R,Donato G,Camastra C,Iuliano R,Cuzzocrea S,Constanti A,De Sarro G Neuronal Migration and Ventral Subtype Identity in the Telencephalon Depend on SOX1 Journal article ; 2005 ; PLoS Biology links: IRIS ; UCL Discovery ; doi ; publisher authors [click to collapse] : Ekonomou A,Kazanis I,Malas S,Woods H,Alifragis P,Denaxa M,Karagogeos D,Constanti A,Lovell-Badge R,Episkopou V The mTOR Signaling Pathway in the Brain: Focus on Epilepsy and Epileptogenesis Journal article ; 2012 ; MOLECULAR NEUROBIOLOGY links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : Russo E,Citraro R,Constanti A,De Sarro G mTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsy Journal article ; 2012 ; Neuropharmacology links: IRIS ; UCL Discovery authors [click to collapse] : Russo E,Citraro R,Donato G,Camastra C,Iuliano R,Cuzzocrea S,Constanti A,De Sarro G MTOR INHIBITION MODULATES EPILEPTOGENESIS, SEIZURES AND DEPRESSIVE-LIKE BEHAVIOR IN A GENETIC MODEL OF ABSENCE SEIZURES AND MILD DEPRESSION COMORBIDITY: A ROLE FOR INFLAMMATORY RESPONSES Conference ; 2012 ; EPILEPSIA links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Russo E,Citraro R,Constanti A,De Sarro G CARBACHOL-INDUCED SUPPRESSION OF THE N-WAVE IN GUINEA-PIG OLFACTORY CORTEX SLICES - WEAK ANTAGONISM BY M3-SELECTIVE MUSCARINIC ANTAGONISTS, HHSID AND P-F-HHSID Journal article ; 1990 ; BRITISH JOURNAL OF PHARMACOLOGY links: IRIS ; UCL Discovery ; author's authors : BAGETTA G,CONSTANTI A EXPRESSION OF VERTEBRATE AMINO-ACID RECEPTORS IN OOCYTES Journal article ; 1985 ; EPILEPSIA links: IRIS ; UCL Discovery ; author's authors [click to collapse] : BROWN D,SMART T,CONSTANTI A,HOUAMED K,BILBE G,BARNARD E Topiramate enhances and prolongs the slow post-stimulus afterhyperpolarization (sAHP) in rat olfactory cortical neurones in vitro. Journal article ; 2002 ; BRITISH JOURNAL OF PHARMACOLOGY links: IRIS ; UCL Discovery ; author's authors : Russo E,Constanti A Muscarinic induction of the post-stimulus afterdepolarizing tail current (I-ADP) in rat olfactory cortical neurones in vitro requires G-protein activation Conference ; 2003 ; BRITISH JOURNAL OF PHARMACOLOGY links: IRIS ; UCL Discovery ; author's authors : Postlewaite M,Constanti A PRE-SYNAPTIC AND POSTSYNAPTIC EFFECTS OF ZINC ON INVITRO PREPYRIFORM NEURONS Journal article ; 1983 ; NEUROSCIENCE LETTERS links: IRIS ; UCL Discovery ; doi ; author's authors : SMART T,CONSTANTI A A DIFFERENT APPROACH FOR PREPARING GUINEA-PIG OLFACTORY CORTEX SLICES Journal article ; 1984 ; JOURNAL OF PHYSIOLOGY-LONDON links: IRIS ; UCL Discovery ; author's authors : CONSTANTI A,SIM J ANTAGONIST-LIKE ACTION OF OXOTREMORINE ON A MUSCARINIC RECEPTOR IN GUINEA-PIG OLFACTORY CORTEX INVITRO Journal article ; 1986 ; TRENDS IN PHARMACOLOGICAL SCIENCES links: IRIS ; UCL Discovery ; author's authors : WILLIAMS S,CONSTANTI A Topiramate modulates L-type calcium currents in rat olfactory cortical neurones in vitro Conference ; 2003 ; BRITISH JOURNAL OF PHARMACOLOGY links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Russo E,Whalley B,Constanti A A SLOW, MUSCARINE-SENSITIVE CA-DEPENDENT-K CURRENT IN GUINEA-PIG OLFACTORY CORTEX NEURONS INVITRO Journal article ; 1985 ; JOURNAL OF PHYSIOLOGY-LONDON links: IRIS ; UCL Discovery ; author's authors : CONSTANTI A,SIM J SYNTHESIS AND INSERTION OF FUNCTIONAL AMINO-ACID RECEPTORS IN XENOPUS-LAEVIS OOCYTES Journal article ; 1986 ; BIOLOGICAL CHEMISTRY HOPPE-SEYLER links: IRIS ; UCL Discovery ; author's authors [click to collapse] : SMART T,HOUAMED K,CONSTANTI A,VANRENTERGHEM C,BROWN D SPONTANEOUS HYPERPOLARIZATIONS IN CULTURED BULLFROG GANGLION-CELLS REFLECT K-CHANNELS OPENED BY INTERNAL CALCIUM PACKETS Journal article ; 1982 ; BIOPHYSICAL JOURNAL links: IRIS ; UCL Discovery ; author's authors [click to collapse] : ADAMS P,BROWN D,CONSTANTI A,ADAMS C A SYSTEM FOR THE TRANSLATION OF RECEPTOR MESSENGER-RNA AND THE STUDY OF THE ASSEMBLY OF FUNCTIONAL RECEPTORS Journal article ; 1984 ; JOURNAL OF RECEPTOR RESEARCH links: IRIS ; UCL Discovery ; doi ; author's authors [click to collapse] : BARNARD E,BEESON D,BILBE G,BROWN D,CONSTANTI A,HOUAMED K,SMART T Sox1 is required for normal cell migration in the ventral telencephalon and loss of function leads to an epileptic phenotype Journal article ; 2000 ; EUROPEAN JOURNAL OF NEUROSCIENCE links: IRIS ; UCL Discovery ; author's authors [click to collapse] : Wood HB,Malas S,Nishiguchi S,Postlethwaite M,Constanti A,Episkopou V ZINC BLOCKS THE A-CURRENT IN CULTURED RAT SYMPATHETIC NEURONS Journal article ; 1988 ; JOURNAL OF PHYSIOLOGY-LONDON links: IRIS ; UCL Discovery ; author's authors : CONSTANTI A,SMART T AN EXPLANATION FOR THE CHOLINOMIMETIC ACTION OF BA-2+ ON SYMPATHETIC NEURONS Journal article ; 1981 ; BRITISH JOURNAL OF PHARMACOLOGY links: IRIS ; UCL Discovery ; author's authors [click to collapse] : ADAMS P,BROWN D,CONSTANTI A