个人简介

2004 PhD Doctor of Philosophy University of Birmingham Biotechnology 2001 MEng Master of Engineering University College London Chemical Engineering with Biochemical Engineering

研究领域

Farlan’s research focuses on the development of robust, reproducible and cost effective production processes in the emerging field of cell therapy. His team are establishing novel processing technologies which will underpin the commercialisation of these types of products. Their work uses a whole bioprocessing methodology pioneered at UCL to ensure that new production process are considered as whole rather than individual operations in isolation. Using pluripotent stem cells as a model system Farlan’s group are developing new methods for the majority of steps involved in the production of cellular therapies. Current projects include the application of bioprocessing methodologies to (i) the expansion of pluripotent stem cells, (ii) their directed differentiation into regenerative populations, (iii) the non-destructive dissociation of differentiated cellular aggregates into single cell suspensions, (iv) purification techniques for positive selection and (v) point-of-care processing which includes cryopreservation, shipping, thawing, washing and presentation of the final therapy ready for administration. The overall goal of this program of work is to develop platform technologies for the manufacture of stem cell therapies.

Basic Life Sciences Bioprocessing Global Health Personalised Medicine Stem Cells & Regenerative Medicine

近期论文

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Early retinal differentiation of human pluripotent stem cells in microwell suspension cultures. Journal article; 2016; Biotechnol Lett Links: IRIS | Author's | DOI Authors: Sharma VS,Khalife R,Tostoes R,Leung L,Kinsella R,Ruban L,Veraitch FS click to collapse Label-free quantification of proliferation and specific oxygen uptake rates from un-disrupted embryonic stem cell cultures in a microfluidic device Conference presentation; 2016; Links: IRIS | Author's Authors: Szita N,Jaccard N,Super A,Macown RJ,Marques MPC,Veraitch FS,Szita N click to collapse Real-time monitoring of specific oxygen uptake rates of embryonic stem cells in a microfluidic cell culture device Journal article; 2016; BIOTECHNOLOGY JOURNAL Links: IRIS | UCL Discovery | Author's | DOI Authors: Super A,Jaccard N,Marques MPC,Macown RJ,Griffin LD,Veraitch FS,Szita N click to collapse Transfection in perfused microfluidic cell culture devices: a case study Journal article; 2016; Process Biochemistry Links: IRIS | UCL Discovery | DOI Authors: Raimes W,Rubi M,Super ASM,Marques M,Veraitch F,Szita N click to collapse The effect of Young's modulus on the neuronal differentiation of mouse embryonic stem cells. Journal article; 2015; Acta biomaterialia Links: IRIS | UCL Discovery Authors: Ali S,Wall IB,Mason C,Pelling AE,Veraitch FS click to collapse Automated and online characterization of adherent cell culture growth in a microfabricated bioreactor. Journal article; 2014; J Lab Autom Links: IRIS | UCL Discovery | Author's | DOI Authors: Jaccard N,Macown RJ,Super A,Griffin LD,Veraitch FS,Szita N click to collapse Automated method for the rapid and precise estimation of adherent cell culture characteristics from phase contrast microscopy images. Journal article; 2014; Biotechnol Bioeng Links: IRIS | UCL Discovery | Author's | DOI Authors: Jaccard N,Griffin LD,Keser A,Macown RJ,Super A,Veraitch FS,Szita N click to collapse Bioprocessing Challenges Associated with the Purification of Cellular Therapies Chapter; 2014; Links: IRIS | UCL Discovery | Author's | DOI | Publisher Authors: Weil BD,Veraitch FS click to collapse Robust, microfabricated culture devices with improved control over the soluble microenvironment for the culture of embryonic stem cells. Journal article; 2014; Biotechnol J Links: IRIS | Author's | DOI Authors: Macown RJ,Veraitch FS,Szita N click to collapse The differential effects of 2% oxygen preconditioning on the subsequent differentiation of mouse and human pluripotent stem cells. Journal article; 2014; Stem Cells Dev Links: IRIS | UCL Discovery | Author's | DOI Authors: Fynes K,Tostoes R,Ruban L,Weil B,Mason C,Veraitch FS click to collapse Development of a multiplexed microfluidic platform for the automated cultivation of embryonic stem cells. Journal article; 2013; J Lab Autom Links: IRIS | UCL Discovery | Author's | DOI Authors: Reichen M,Veraitch FS,Szita N click to collapse Oxygen-controlled automated neural differentiation of mouse embryonic stem cells. Journal article; 2013; Regen Med Links: IRIS | UCL Discovery | Author's | DOI | Publisher Authors: Mondragon-Teran P,Tostoes R,Mason C,Lye GJ,Veraitch FS click to collapse Reproducible culture and differentiation of mouse embryonic stem cells using an automated microwell platform. Journal article; 2013; Biochem Eng J Links: IRIS | UCL Discovery | Author's | DOI Authors: Hussain W,Moens N,Veraitch FS,Hernandez D,Mason C,Lye GJ click to collapse Hypoxia enhances the generation of retinal progenitor cells from human induced pluripotent and embryonic stem cells. Journal article; 2012; Stem Cells Dev Links: IRIS | UCL Discovery | Author's | DOI Authors: Bae D,Mondragon-Teran P,Hernandez D,Ruban L,Mason C,Bhattacharya SS,Veraitch FS click to collapse Hypoxic culture of human pluripotent stem cell lines is permissible using mouse embryonic fibroblasts Journal article; 2012; Regenerative Medicine Links: IRIS | UCL Discovery | DOI Authors: Badger JL,Byrne ML,Veraitch FS,Mason C,Caldwell MA,Wall IB click to collapse Microfabricated modular scale-down device for regenerative medicine process development Journal article; 2012; Links: IRIS | UCL Discovery | DOI | Publisher Authors: Reichen M,Macown RJ,Jaccard N,Super A,Ruban L,Griffin L,Veraitch FS,Szita N click to collapse Precisely delivered nano-mechanical forces induce blebbing in undifferentiated mouse embryonic stem cells Journal article; 2011; Cell Health and Cytoskeleton Links: IRIS | UCL Discovery | DOI Authors: Hemsley AL,Hernandez D,Mason C,Pelling AE,Veraitch FS click to collapse The full spectrum of physiological oxygen tensions and step-changes in oxygen tension affects the neural differentiation of mouse embryonic stem cells. Journal article; 2011; Biotechnol Prog Links: IRIS | UCL Discovery | Author's | DOI Authors: Mondragon-Teran P,Baboo JZ,Mason C,Lye GJ,Veraitch FS click to collapse The release of single cells from embryoid bodies in a capillary flow device Journal article; 2011; CHEMICAL ENGINEERING SCIENCE Links: IRIS | UCL Discovery | Author's | DOI Authors: Papantoniou I,Hoare M,Veraitch FS click to collapse An automated and multiplexed microfluidic bioreactor platform with time-lapse imaging for cultivation of embryonic stem cells and on-line assessment of morphology and pluripotency markers Conference ; 2010; Links: IRIS | UCL Discovery Authors: Reichen M,Veraitch FS,Szita N click to collapse Automated stem cell culture with a twist Journal article; 2010; Genetic Engineering News Links: IRIS | UCL Discovery Authors: Veraitch FS,Lye GJ click to collapse Bioprocessing challenges for regenerative medicine Conference ; 2010; Links: IRIS | UCL Discovery Authors: Veraitch FS Embryonic stem cell bioprocessing Conference ; 2010; Links: IRIS | UCL Discovery Authors: Veraitch FS Embryonic stem cell bioprocessing Conference ; 2010; Links: IRIS | UCL Discovery Authors: Veraitch FS Embryonic stem cell bioprocessing Conference ; 2010; Links: IRIS | UCL Discovery Authors: Veraitch FS